Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Staphylococcus aureus | DNA gyrase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania mexicana | mitochondrial DNA topoisomerase II | DNA gyrase | 644 aa | 620 aa | 23.4 % |
Leishmania braziliensis | DNA topoisomerase ii | DNA gyrase | 644 aa | 675 aa | 23.0 % |
Loa Loa (eye worm) | TOPoisomerase family member | DNA gyrase | 644 aa | 668 aa | 26.2 % |
Trypanosoma brucei gambiense | DNA topoisomerase II, putative | DNA gyrase | 644 aa | 619 aa | 25.7 % |
Trypanosoma cruzi | DNA topoisomerase II, putative | DNA gyrase | 644 aa | 674 aa | 23.0 % |
Theileria parva | DNA topoisomerase II, putative | DNA gyrase | 644 aa | 683 aa | 23.9 % |
Toxoplasma gondii | DNA topoisomerase 2, putative | DNA gyrase | 644 aa | 664 aa | 24.1 % |
Leishmania major | mitochondrial DNA topoisomerase II | DNA gyrase | 644 aa | 624 aa | 23.1 % |
Schistosoma mansoni | DNA topoisomerase II | DNA gyrase | 644 aa | 633 aa | 24.3 % |
Trypanosoma brucei | DNA topoisomerase II beta, putative | DNA gyrase | 644 aa | 570 aa | 24.0 % |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | DNA gyrase | 644 aa | 548 aa | 25.7 % |
Brugia malayi | DNA topoisomerase II, alpha isozyme | DNA gyrase | 644 aa | 659 aa | 24.3 % |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | DNA gyrase | 644 aa | 615 aa | 22.6 % |
Candida albicans | DNA topoisomerase II similar to S. cerevisiae TOP2 (YNL088W) | DNA gyrase | 644 aa | 625 aa | 25.6 % |
Plasmodium berghei | DNA gyrase subunit B, putative | DNA gyrase | 644 aa | 662 aa | 36.3 % |
Plasmodium falciparum | DNA topoisomerase 2 | DNA gyrase | 644 aa | 647 aa | 23.2 % |
Entamoeba histolytica | DNA topoisomerase II, putative | DNA gyrase | 644 aa | 544 aa | 25.0 % |
Leishmania infantum | mitochondrial DNA topoisomerase II | DNA gyrase | 644 aa | 624 aa | 23.2 % |
Onchocerca volvulus | DNA gyrase | 644 aa | 618 aa | 26.5 % | |
Leishmania mexicana | DNA topoisomerase ii | DNA gyrase | 644 aa | 668 aa | 23.1 % |
Onchocerca volvulus | Ectoderm-expressed 4 homolog | DNA gyrase | 644 aa | 673 aa | 24.1 % |
Candida albicans | DNA topoisomerase II similar to S. cerevisiae TOP2 (YNL088W) | DNA gyrase | 644 aa | 625 aa | 25.6 % |
Trypanosoma brucei | DNA topoisomerase ii | DNA gyrase | 644 aa | 619 aa | 25.7 % |
Dictyostelium discoideum | DNA topoisomerase II | DNA gyrase | 644 aa | 655 aa | 23.8 % |
Trypanosoma cruzi | DNA topoisomerase II, putative | DNA gyrase | 644 aa | 674 aa | 23.0 % |
Chlamydia trachomatis | DNA gyrase subunit B | DNA gyrase | 644 aa | 561 aa | 55.3 % |
Theileria parva | DNA gyrase subunit B, putative | DNA gyrase | 644 aa | 638 aa | 37.1 % |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | DNA gyrase | 644 aa | 661 aa | 53.0 % |
Plasmodium knowlesi | DNA gyrase subunit B, putative | DNA gyrase | 644 aa | 517 aa | 36.0 % |
Trypanosoma congolense | DNA topoisomerase II, putative | DNA gyrase | 644 aa | 678 aa | 22.7 % |
Trypanosoma congolense | DNA topoisomerase II, putative | DNA gyrase | 644 aa | 678 aa | 22.9 % |
Leishmania braziliensis | mitochondrial DNA topoisomerase II | DNA gyrase | 644 aa | 622 aa | 23.8 % |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | DNA gyrase | 644 aa | 612 aa | 25.8 % |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | DNA gyrase | 644 aa | 615 aa | 22.6 % |
Echinococcus granulosus | DNA topoisomerase 2 alpha | DNA gyrase | 644 aa | 613 aa | 25.9 % |
Leishmania infantum | DNA topoisomerase ii | DNA gyrase | 644 aa | 666 aa | 23.6 % |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | DNA gyrase | 644 aa | 667 aa | 53.1 % |
Leishmania major | DNA topoisomerase ii | DNA gyrase | 644 aa | 672 aa | 23.4 % |
Babesia bovis | DNA topoisomerase II, putative | DNA gyrase | 644 aa | 587 aa | 22.7 % |
Mycobacterium ulcerans | DNA gyrase subunit B | DNA gyrase | 644 aa | 663 aa | 54.0 % |
Brugia malayi | Probable DNA topoisomerase II | DNA gyrase | 644 aa | 672 aa | 25.9 % |
Leishmania donovani | mitochondrial DNA topoisomerase II | DNA gyrase | 644 aa | 624 aa | 23.2 % |
Neospora caninum | hypothetical protein | DNA gyrase | 644 aa | 693 aa | 24.1 % |
Trypanosoma brucei gambiense | DNA topoisomerase II, putative | DNA gyrase | 644 aa | 676 aa | 23.4 % |
Trypanosoma congolense | DNA topoisomerase II, putative | DNA gyrase | 644 aa | 617 aa | 24.8 % |
Onchocerca volvulus | DNA gyrase | 644 aa | 624 aa | 25.8 % | |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | DNA gyrase | 644 aa | 676 aa | 23.4 % |
Trypanosoma brucei gambiense | DNA topoisomerase II, putative | DNA gyrase | 644 aa | 666 aa | 23.4 % |
Leishmania donovani | DNA topoisomerase ii | DNA gyrase | 644 aa | 666 aa | 23.4 % |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | DNA gyrase | 644 aa | 561 aa | 50.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | DNA topoisomerase II | 0.004 | 0.1852 | 0.5 |
Trypanosoma brucei | DNA topoisomerase ii | 0.004 | 0.1852 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0065 | 0.3985 | 0.5 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.004 | 0.1852 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0072 | 0.4547 | 0.3308 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.004 | 0.1852 | 0.5 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0136 | 1 | 1 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0136 | 1 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0072 | 0.4547 | 0.3308 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.004 | 0.1852 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0136 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.004 | 0.1852 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.004 | 0.1852 | 0.1278 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0136 | 1 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.004 | 0.1852 | 0.5 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.004 | 0.1852 | 0.5 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0136 | 1 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.004 | 0.1852 | 1 |
Onchocerca volvulus | 0.0054 | 0.3064 | 1 | |
Brugia malayi | Probable DNA topoisomerase II | 0.004 | 0.1852 | 0.5 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.004 | 0.1852 | 0.5 |
Giardia lamblia | DNA topoisomerase II | 0.0036 | 0.1563 | 0.5 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.004 | 0.1852 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0136 | 1 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.004 | 0.1852 | 0.5 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0136 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.04 ug ml-1 | Inhibition of Staphylococcus aureus DNA gyrase ATPase subunit GyrA2/GyrB2 after 60 mins by malachite green staining assay | ChEMBL. | 24239017 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.