Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Staphylococcus aureus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Dihydrofolate reductase | 0.0415 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0415 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0415 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0415 | 1 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0241 | 0 | 0.5 |
Onchocerca volvulus | 0.0304 | 0.365 | 0.5 | |
Leishmania major | stearic acid desaturase, putative | 0.0304 | 0.365 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0415 | 1 | 0.5 |
Onchocerca volvulus | 0.0304 | 0.365 | 0.5 | |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0304 | 0.365 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0304 | 0.365 | 1 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0241 | 0 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0415 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0415 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0415 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0415 | 1 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.0304 | 0.365 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.002 nM | Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometric analysis in presence of NADPH | ChEMBL. | 24428639 |
Ki (binding) | = 0.002 nM | BindingDB_Patents: Inhibition Assay. Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known (see., e.g., National Committee for Clinical Laboratory Standards 2000 Performance standards for antimicrobial disk susceptibility tests: approved standard, 7th ed. M2-A7, vol. 20, no. 1, Committee for Clinical Laboratory Standards, Wayne, Pa.). | ChEMBL. | No reference |
Ki (binding) | = 93 nM | Inhibition of human DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometric analysis in presence of NADPH | ChEMBL. | 24428639 |
Ki (binding) | = 93.5 nM | Inhibition Assay | BINDINGDB. | No reference |
Vd (ADMET) | = 4.4 L/Kg | Apparent volume of distribution in BALB/c mouse at 5 mg/kg, iv | ChEMBL. | 24428639 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.