Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 4 | Starlite/ChEMBL | References |
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0202 | 0.2173 | 0.2173 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0064 | 0.0354 | 0.0354 |
Brugia malayi | Protein kinase domain | 0.0064 | 0.0354 | 0.1325 |
Brugia malayi | serine/threonine-protein kinase PAK 7 | 0.024 | 0.2671 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0795 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0795 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0795 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0795 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0202 | 0.2173 | 0.2173 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0795 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0038 | 0.001 | 0.0277 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0795 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0064 | 0.0354 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0795 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0064 | 0.0354 | 0.0354 |
Trichomonas vaginalis | STE family protein kinase | 0.0064 | 0.0354 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0064 | 0.0354 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0064 | 0.0354 | 0.0354 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0064 | 0.0354 | 0.0354 |
Entamoeba histolytica | protein kinase, putative | 0.0038 | 0.001 | 0.0277 |
Entamoeba histolytica | p21-activated kinase | 0.0064 | 0.0354 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0795 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0038 | 0.001 | 0.001 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0038 | 0.001 | 0.001 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0064 | 0.0354 | 0.0354 |
Entamoeba histolytica | protein kinase, putative | 0.0064 | 0.0354 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0038 | 0.001 | 0.0277 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0064 | 0.0344 | 0.9715 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0795 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0064 | 0.0354 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0344 | 0.1288 |
Schistosoma mansoni | protein kinase | 0.0064 | 0.0354 | 0.0354 |
Trichomonas vaginalis | STE family protein kinase | 0.0064 | 0.0354 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.024 | 0.2671 | 1 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0064 | 0.0354 | 0.0354 |
Schistosoma mansoni | protein kinase | 0.0064 | 0.0354 | 0.0354 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.67 uM | Binding affinity to N-terminal GST-tagged recombinant human PAK4 kinase domain expressed in Escherichia coli using KKRNRRLSVA as substrate preincubated for 10 mins followed by ATP addition measured after 60 mins by FRET-based Z'Lyte assay | ChEMBL. | 24432870 |
Ki (binding) | > 4.5 uM | Binding affinity to N-terminal GST-His-tagged recombinant human PAK1 kinase domain expressed in Escherichia coli BL21 using KKRNRRLSVA as sustrate preincubated for 10 mins followed by ATP addition measured after 60 mins by FRET-based Z'Lyte assay | ChEMBL. | 24432870 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.