Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenergic, beta, receptor kinase 1 | Starlite/ChEMBL | References |
Homo sapiens | G protein-coupled receptor kinase 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.0138 | 0.7518 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0135 | 0.7313 | 0.9727 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.009 | 0.3583 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0138 | 0.7518 | 1 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0088 | 0.3447 | 0.4439 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0092 | 0.3788 | 0.3788 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0129 | 0.6781 | 0.8733 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.009 | 0.3583 | 0.4614 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.009 | 0.3583 | 0.4614 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0141 | 0.7765 | 0.7765 |
Giardia lamblia | Kinase, AGC PKA | 0.009 | 0.3583 | 0.5 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0138 | 0.7518 | 0.7518 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.0141 | 0.7765 | 1 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.0141 | 0.7765 | 0.7765 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0168 | 1 | 1 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0135 | 0.7313 | 0.7313 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0129 | 0.6781 | 0.6781 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.0141 | 0.7765 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0138 | 0.7518 | 1 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0168 | 1 | 1 |
Trypanosoma cruzi | Protein kinase B | 0.0092 | 0.3788 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0092 | 0.3788 | 0.5038 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0129 | 0.6781 | 0.6781 |
Toxoplasma gondii | AGC kinase | 0.0135 | 0.7313 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0138 | 0.7518 | 1 |
Echinococcus granulosus | nervana 2 | 0.0088 | 0.3447 | 0.4439 |
Echinococcus granulosus | G protein coupled receptor kinase 1 | 0.0102 | 0.4546 | 0.5855 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0141 | 0.7765 | 0.7765 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0092 | 0.3788 | 1 |
Entamoeba histolytica | protein kinase 2, putative | 0.009 | 0.3583 | 0.4765 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0088 | 0.3447 | 0.4439 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0129 | 0.6781 | 0.8733 |
Trichomonas vaginalis | AGC family protein kinase | 0.0138 | 0.7518 | 1 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0092 | 0.3788 | 0.4878 |
Trichomonas vaginalis | AGC family protein kinase | 0.0138 | 0.7518 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0092 | 0.3788 | 0.3788 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0092 | 0.3788 | 0.4878 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0092 | 0.3788 | 0.5038 |
Echinococcus multilocularis | G protein coupled receptor kinase 1 | 0.0102 | 0.4546 | 0.5855 |
Trichomonas vaginalis | AGC family protein kinase | 0.0049 | 0.0205 | 0.0273 |
Echinococcus multilocularis | nervana 2 | 0.0088 | 0.3447 | 0.4439 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0138 | 0.7518 | 0.5 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0088 | 0.3447 | 0.4439 |
Entamoeba histolytica | protein kinase, putative | 0.0138 | 0.7518 | 1 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0135 | 0.7313 | 0.7313 |
Echinococcus multilocularis | nervana 2 | 0.0088 | 0.3447 | 0.4439 |
Trichomonas vaginalis | AGC family protein kinase | 0.0138 | 0.7518 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.009 | 0.3583 | 0.4614 |
Echinococcus granulosus | nervana 2 | 0.0088 | 0.3447 | 0.4439 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.009 | 0.3583 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0138 | 0.7518 | 0.7518 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0129 | 0.6781 | 0.6781 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0088 | 0.3447 | 0.4439 |
Trichomonas vaginalis | AGC family protein kinase | 0.0138 | 0.7518 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.36 uM | Inhibition of GRK-5 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRET assay | ChEMBL. | 24210504 |
IC50 (binding) | > 10 uM | Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRET assay | ChEMBL. | 24210504 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.