Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Homo sapiens | tachykinin receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 4 | 630 aa | 574 aa | 31.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | defective proboscis extension response | 0.004 | 0.0047 | 0.3425 |
Echinococcus multilocularis | Immunoglobulin | 0.004 | 0.0047 | 0.3425 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0657 | 0.174 | 0.174 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.004 | 0.0047 | 0.3425 |
Echinococcus multilocularis | roundabout 2 | 0.0064 | 0.0111 | 0.8182 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0136 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0047 | 0.0047 |
Echinococcus multilocularis | serotonin transporter | 0.0073 | 0.0136 | 1 |
Brugia malayi | Fibronectin type III domain containing protein | 0.004 | 0.0047 | 0.0268 |
Echinococcus granulosus | neuroglian | 0.0051 | 0.0075 | 0.5514 |
Brugia malayi | hypothetical protein | 0.004 | 0.0047 | 0.0268 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.3663 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.3663 | 1 | 0.5 |
Schistosoma mansoni | vesicular amine transporter | 0.004 | 0.0047 | 0.3425 |
Echinococcus granulosus | roundabout 2 | 0.0064 | 0.0111 | 0.8182 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.004 | 0.0047 | 0.3425 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0111 | 0.0111 |
Schistosoma mansoni | cell adhesion molecule | 0.0054 | 0.0083 | 0.6092 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0047 | 0.0047 |
Echinococcus granulosus | Immunoglobulin | 0.004 | 0.0047 | 0.3425 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0073 | 0.0136 | 1 |
Onchocerca volvulus | 0.06 | 0.1585 | 0.978 | |
Loa Loa (eye worm) | hypothetical protein | 0.3663 | 1 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0657 | 0.174 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3663 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0026 | 0.0007 | 0.053 |
Echinococcus granulosus | serotonin transporter | 0.0073 | 0.0136 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0073 | 0.0136 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0136 | 0.0136 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0073 | 0.0136 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0047 | 0.0047 |
Echinococcus multilocularis | neuroglian | 0.0051 | 0.0075 | 0.5514 |
Echinococcus granulosus | twitchin | 0.0051 | 0.0075 | 0.5514 |
Onchocerca volvulus | 0.0073 | 0.0136 | 0.0839 | |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0111 | 0.0111 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0613 | 0.162 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0073 | 0.0136 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0083 | 0.0083 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.004 | 0.0047 | 0.3425 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0136 | 0.0136 |
Echinococcus multilocularis | Immunoglobulin | 0.004 | 0.0047 | 0.3425 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.004 | 0.0047 | 0.0268 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0073 | 0.0136 | 0.0781 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0047 | 0.0047 |
Schistosoma mansoni | nephrin | 0.0051 | 0.0075 | 0.5514 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0047 | 0.0047 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0073 | 0.0136 | 0.5 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0054 | 0.0083 | 0.6092 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0047 | 0.0047 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0073 | 0.0136 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.