Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0171424 | 0.0650953 | 0.0650953 |
Brugia malayi | Animal haem peroxidase family protein | 0.00262251 | 0.00281231 | 0.00281231 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0111258 | 0.039287 | 0.039287 |
Brugia malayi | Protein kinase domain containing protein | 0.168428 | 0.714035 | 0.714035 |
Brugia malayi | Blistered cuticle protein 3 | 0.00262251 | 0.00281231 | 0.00281231 |
Loa Loa (eye worm) | hypothetical protein | 0.00262251 | 0.00281231 | 0.00281231 |
Echinococcus granulosus | peroxidasin | 0.00262251 | 0.00281231 | 0.00281231 |
Brugia malayi | Peroxidasin | 0.00262251 | 0.00281231 | 0.00281231 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0158779 | 0.0596714 | 1 |
Onchocerca volvulus | 0.00262251 | 0.00281231 | 0.0432029 | |
Brugia malayi | Animal haem peroxidase family protein | 0.00262251 | 0.00281231 | 0.00281231 |
Echinococcus granulosus | MAM | 0.0171424 | 0.0650953 | 0.0650953 |
Onchocerca volvulus | 0.00262251 | 0.00281231 | 0.0432029 | |
Schistosoma mansoni | hypothetical protein | 0.0171424 | 0.0650953 | 0.0650953 |
Schistosoma mansoni | peroxidasin | 0.00262251 | 0.00281231 | 0.00281231 |
Loa Loa (eye worm) | hypothetical protein | 0.00262251 | 0.00281231 | 0.00281231 |
Loa Loa (eye worm) | indoleamine 2,3-dioxygenase | 0.235095 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.00262251 | 0.00281231 | 0.0432029 |
Loa Loa (eye worm) | hypothetical protein | 0.00262251 | 0.00281231 | 0.00281231 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.00262251 | 0.00281231 | 0.00281231 |
Loa Loa (eye worm) | hypothetical protein | 0.00262251 | 0.00281231 | 0.00281231 |
Echinococcus granulosus | indoleamine 23 dioxygenase 2 | 0.235095 | 1 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0111258 | 0.039287 | 0.039287 |
Onchocerca volvulus | Peroxidasin homolog | 0.00262251 | 0.00281231 | 0.0432029 |
Loa Loa (eye worm) | animal heme peroxidase | 0.00262251 | 0.00281231 | 0.00281231 |
Loa Loa (eye worm) | hypothetical protein | 0.00262251 | 0.00281231 | 0.00281231 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.168314 | 0.713544 | 0.713544 |
Schistosoma mansoni | hypothetical protein | 0.235095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00262251 | 0.00281231 | 0.00281231 |
Echinococcus multilocularis | indoleamine 2,3 dioxygenase 2 | 0.235095 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.00262251 | 0.00281231 | 0.00281231 |
Loa Loa (eye worm) | hypothetical protein | 0.0171424 | 0.0650953 | 0.0650953 |
Loa Loa (eye worm) | hypothetical protein | 0.150404 | 0.636719 | 0.636719 |
Schistosoma mansoni | hypothetical protein | 0.0171424 | 0.0650953 | 0.0650953 |
Loa Loa (eye worm) | hypothetical protein | 0.00262251 | 0.00281231 | 0.00281231 |
Onchocerca volvulus | Peroxidase homolog | 0.00262251 | 0.00281231 | 0.0432029 |
Loa Loa (eye worm) | hypothetical protein | 0.0171424 | 0.0650953 | 0.0650953 |
Schistosoma mansoni | lipoxygenase | 0.00758538 | 0.0241005 | 0.0241005 |
Onchocerca volvulus | 0.0171424 | 0.0650953 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.00262251 | 0.00281231 | 0.00281231 |
Loa Loa (eye worm) | hypothetical protein | 0.00262251 | 0.00281231 | 0.00281231 |
Onchocerca volvulus | Peroxidasin homolog | 0.00262251 | 0.00281231 | 0.0432029 |
Loa Loa (eye worm) | animal heme peroxidase | 0.00262251 | 0.00281231 | 0.00281231 |
Loa Loa (eye worm) | animal heme peroxidase | 0.00262251 | 0.00281231 | 0.00281231 |
Loa Loa (eye worm) | animal heme peroxidase | 0.00262251 | 0.00281231 | 0.00281231 |
Brugia malayi | Animal haem peroxidase family protein | 0.00262251 | 0.00281231 | 0.00281231 |
Schistosoma mansoni | lipoxygenase | 0.0111258 | 0.039287 | 0.039287 |
Echinococcus multilocularis | MAM | 0.0171424 | 0.0650953 | 0.0650953 |
Schistosoma mansoni | peroxidasin | 0.00262251 | 0.00281231 | 0.00281231 |
Onchocerca volvulus | 0.0171424 | 0.0650953 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.00262251 | 0.00281231 | 0.00281231 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.00262251 | 0.00281231 | 0.0432029 |
Schistosoma mansoni | hypothetical protein | 0.235095 | 1 | 1 |
Onchocerca volvulus | 0.00262251 | 0.00281231 | 0.0432029 | |
Brugia malayi | Animal haem peroxidase family protein | 0.00262251 | 0.00281231 | 0.00281231 |
Onchocerca volvulus | Dual oxidase homolog | 0.00262251 | 0.00281231 | 0.0432029 |
Toxoplasma gondii | cell-cycle-associated protein kinase, putative | 0.014765 | 0.0548974 | 0.5 |
Plasmodium falciparum | MO15-related protein kinase | 0.0158779 | 0.0596714 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00262251 | 0.00281231 | 0.00281231 |
Brugia malayi | indoleamine 2,3-dioxygenase | 0.235095 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.00262251 | 0.00281231 | 0.00281231 |
Loa Loa (eye worm) | hypothetical protein | 0.0171424 | 0.0650953 | 0.0650953 |
Loa Loa (eye worm) | hypothetical protein | 0.00262251 | 0.00281231 | 0.00281231 |
Loa Loa (eye worm) | hypothetical protein | 0.00262251 | 0.00281231 | 0.00281231 |
Loa Loa (eye worm) | hypothetical protein | 0.00262251 | 0.00281231 | 0.00281231 |
Echinococcus multilocularis | peroxidasin | 0.00262251 | 0.00281231 | 0.00281231 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Toxicity in BALB/c mouse assessed as mortality at 1 mg/kg/day, ip | ChEMBL. | 24448422 | |
Activity (functional) | = 13 % | Antitrypanosomal activity against Trypanosoma cruzi (IRHOD/CO/2008/SN3) epimastigotes assessed as change in succinate level at IC25 after 96 hrs by [1H]-NMR spectroscopic analysis relative to control | ChEMBL. | 24448422 |
IC50 (functional) | = 14.5 uM | Antitrypanosomal activity against Trypanosoma cruzi (IRHOD/CO/2008/SN3) trypomastigotes infected in Balb/c albino mouse after 24 hrs by Neubauer chamber counting analysis | ChEMBL. | 24448422 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | 24448422 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.