Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | poly (ADP-ribose) polymerase family, member 3 | Starlite/ChEMBL | References |
Homo sapiens | poly (ADP-ribose) polymerase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | poly(adp-ribose) polymerase | poly (ADP-ribose) polymerase family, member 3 | 540 aa | 497 aa | 37.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0101 | 0.1193 | 0.123 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0215 | 0.6238 | 0.3116 |
Trypanosoma brucei | poly(adp-ribose) polymerase | 0.0215 | 0.6238 | 0.5 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0215 | 0.6238 | 0.5 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0293 | 0.9699 | 1 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0215 | 0.6238 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.4655 | 0.5175 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0293 | 0.9699 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.6238 | 1 |
Brugia malayi | WGR domain containing protein | 0.0293 | 0.9699 | 1 |
Echinococcus granulosus | WGR domain containing protein | 0.0101 | 0.1193 | 0.123 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0293 | 0.9699 | 1 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0215 | 0.6238 | 0.6431 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0293 | 0.9699 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta Tm (binding) | = 0 degrees C | Binding affinity to ATRD8 (unknown origin) assessed as change in melting temperature by thermal stabilization assay | ChEMBL. | 24188023 |
Delta Tm (binding) | = 0.94 degrees C | Binding affinity to ATRD2 (unknown origin) assessed as change in melting temperature by thermal stabilization assay | ChEMBL. | 24188023 |
Delta Tm (binding) | = 3.43 degrees C | Binding affinity to ATRD1 (unknown origin) assessed as change in melting temperature by thermal stabilization assay | ChEMBL. | 24188023 |
Delta Tm (binding) | = 7.28 degrees C | Binding affinity to ATRD3 (unknown origin) assessed as change in melting temperature by thermal stabilization assay | ChEMBL. | 24188023 |
IC50 (binding) | = 1.98 uM | Inhibition of catalytic domain of ATRD1 (unknown origin) | ChEMBL. | 24188023 |
IC50 (binding) | = 11.1 uM | Inhibition of full length ATRD3 (unknown origin) | ChEMBL. | 24188023 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.