Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0121 | 0.0431 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0718 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0718 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0431 | 0.0421 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0121 | 0.0431 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0121 | 0.0431 | 0.0421 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0718 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0718 | 1 | 1 |
Onchocerca volvulus | 0.0121 | 0.0431 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0718 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0121 | 0.0431 | 0.0421 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0718 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0121 | 0.0431 | 0.0421 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0121 | 0.0431 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0431 | 0.0421 |
Brugia malayi | Carboxylesterase family protein | 0.0718 | 1 | 1 |
Onchocerca volvulus | 0.0121 | 0.0431 | 1 | |
Schistosoma mansoni | gliotactin | 0.0121 | 0.0431 | 0.0421 |
Echinococcus multilocularis | acetylcholinesterase | 0.0718 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0121 | 0.0431 | 0.0421 |
Schistosoma mansoni | hypothetical protein | 0.0231 | 0.2198 | 0.219 |
Echinococcus granulosus | hypothetical protein | 0.0294 | 0.3208 | 0.3201 |
Echinococcus granulosus | carboxylesterase 5A | 0.0718 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0121 | 0.0431 | 0.0421 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0121 | 0.0431 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0121 | 0.0431 | 0.0421 |
Brugia malayi | Carboxylesterase family protein | 0.0121 | 0.0431 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0431 | 0.0421 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0121 | 0.0431 | 0.0421 |
Brugia malayi | Carboxylesterase family protein | 0.0121 | 0.0431 | 0.0421 |
Echinococcus multilocularis | neuroligin | 0.0121 | 0.0431 | 0.0421 |
Onchocerca volvulus | 0.0121 | 0.0431 | 1 | |
Onchocerca volvulus | 0.0121 | 0.0431 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0431 | 0.0421 |
Echinococcus multilocularis | acetylcholinesterase | 0.0718 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0431 | 0.0421 |
Loa Loa (eye worm) | carboxylesterase | 0.0121 | 0.0431 | 0.0421 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0121 | 0.0431 | 0.0421 |
Echinococcus granulosus | neuroligin | 0.0121 | 0.0431 | 0.0421 |
Onchocerca volvulus | 0.0121 | 0.0431 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0121 | 0.0431 | 0.0421 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0718 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0121 | 0.0431 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0431 | 0.0421 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0121 | 0.0431 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0121 | 0.0431 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0121 | 0.0431 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0431 | 0.0421 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0121 | 0.0431 | 0.0421 |
Brugia malayi | Carboxylesterase family protein | 0.0121 | 0.0431 | 0.0421 |
Brugia malayi | hypothetical protein | 0.0121 | 0.0431 | 0.0421 |
Brugia malayi | Carboxylesterase family protein | 0.0121 | 0.0431 | 0.0421 |
Echinococcus granulosus | acetylcholinesterase | 0.0718 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0121 | 0.0431 | 0.0421 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Toxicity in mouse infected with Trypanosoma brucei rhodesiense at 50 mg/kg, ip measured after day 3 | ChEMBL. | 24398295 | |
Activity (functional) | = 100 % | Antitrypanosomal activity against Trypanosoma brucei rhodesiense infected in mouse assessed as cure rate at 40 mg/kg, ip administered on day 1 to 3 relative to control | ChEMBL. | 24398295 |
IC50 (functional) | = 86 nM | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 assessed as parasite growth inhibition after 70 hrs by Alamar blue assay | ChEMBL. | 24398295 |
MSD (functional) | = 34 day | Antitrypanosomal activity against Trypanosoma brucei rhodesiense infected in mouse assessed as mean survival days at 50 mg/kg, ip administered on day 3 to 6 (Rvb = 6 to 10 days) | ChEMBL. | 24398295 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | 24398295 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.