Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | No references |
Homo sapiens | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 477 aa | 431 aa | 34.6 % |
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | 0.0142 | 0.0172 | 0.5 |
Loa Loa (eye worm) | SPRY domain-containing protein | 0.0131 | 0.0095 | 0.0095 |
Echinococcus granulosus | wd40 repeat | 0.0245 | 0.0878 | 0.0718 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0191 | 0.0511 | 0.0345 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.0878 | 0.0878 |
Echinococcus multilocularis | protein will die slowly | 0.1577 | 1 | 1 |
Brugia malayi | SPRY domain containing protein | 0.0142 | 0.0172 | 0.0101 |
Plasmodium falciparum | SPRY domain, putative | 0.0142 | 0.0172 | 0.5 |
Toxoplasma gondii | SPRY domain-containing protein | 0.0131 | 0.0095 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0127 | 0.0072 | 0.0072 |
Schistosoma mansoni | hypothetical protein | 0.1577 | 1 | 1 |
Onchocerca volvulus | 0.1577 | 1 | 1 | |
Schistosoma mansoni | retinoblastoma binding protein | 0.0245 | 0.0878 | 0.0718 |
Trichomonas vaginalis | WD repeat domain, putative | 0.1577 | 1 | 1 |
Loa Loa (eye worm) | WD40 repeat protein | 0.1577 | 1 | 1 |
Echinococcus granulosus | protein will die slowly | 0.1577 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142 | 0.0172 | 0.0078 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0245 | 0.0878 | 0.0791 |
Loa Loa (eye worm) | SPRY domain-containing protein | 0.0142 | 0.0172 | 0.0172 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142 | 0.0172 | 0.0078 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0191 | 0.0511 | 0.0345 |
Echinococcus multilocularis | wd40 repeat | 0.0245 | 0.0878 | 0.0718 |
Trichomonas vaginalis | retinoblastoma binding protein, putative | 0.0245 | 0.0878 | 0.0791 |
Brugia malayi | Hypothetical WD-repeat protein F21H12.1 in chromosome II | 0.0245 | 0.0878 | 0.0812 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 85 % | Inhibition of gelatinase-A (MMP-2) at a concentration of 1 microM | ChEMBL. | No reference |
Inhibition (binding) | = 85 % | Inhibition of gelatinase-A (MMP-2) at a concentration of 1 microM | ChEMBL. | No reference |
Ki (binding) | = 70 nM | Inhibition of stromelysin-1 (MMP-3). | ChEMBL. | No reference |
Ki (binding) | = 70 nM | Inhibition of stromelysin-1 (MMP-3). | ChEMBL. | No reference |
Ki (binding) | >= 10 uM | Inhibition of collagenase-1 (MMP-1). | ChEMBL. | No reference |
Ki (binding) | >= 10 uM | Inhibition of collagenase-1 (MMP-1). | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.