Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | cell division cycle 25B | Starlite/ChEMBL | References |
Homo sapiens | dual specificity phosphatase 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | kinetoplastid-specific dual specificity phosphatase, putative | dual specificity phosphatase 3 | 185 aa | 182 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0068 | 0.0358 | 1 | |
Echinococcus granulosus | macrophage expressed protein | 0.0226 | 0.2761 | 0.8079 |
Onchocerca volvulus | 0.0068 | 0.0358 | 1 | |
Onchocerca volvulus | 0.0068 | 0.0358 | 1 | |
Onchocerca volvulus | 0.0068 | 0.0358 | 1 | |
Brugia malayi | Rhodanese-like domain containing protein | 0.0068 | 0.0358 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0358 | 1 |
Echinococcus multilocularis | macrophage expressed protein | 0.0226 | 0.2761 | 0.8079 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0358 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0188 | 0.2183 | 0.6387 |
Brugia malayi | Rhodanese-like domain containing protein | 0.0068 | 0.0358 | 1 |
Schistosoma mansoni | m-phase inducer phosphatase(cdc25) | 0.0068 | 0.0358 | 0.1046 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0269 | 0.3417 | 1 |
Trichomonas vaginalis | pps1 dual specificty phosphatase, putative | 0.07 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0226 | 0.2761 | 0.8079 |
Echinococcus granulosus | m phase inducer phosphatasecdc25 | 0.0068 | 0.0358 | 0.1046 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0276 | 0.772 |
Echinococcus multilocularis | m phase inducer phosphatase(cdc25) | 0.0068 | 0.0358 | 0.1046 |
Schistosoma mansoni | lipoxygenase | 0.0269 | 0.3417 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0269 | 0.3417 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0276 | 0.772 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.4 uM | Inhibitory activity against cell division cycle 25B | ChEMBL. | 11563920 |
IC50 (binding) | = 0.4 uM | Inhibitory activity against cell division cycle 25B | ChEMBL. | 11563920 |
IC50 (binding) | = 12.4 uM | Inhibitory activity against vaccinia VH1-related phosphatase(VHR) | ChEMBL. | 11563920 |
IC50 (binding) | = 12.4 uM | Inhibitory activity against vaccinia VH1-related phosphatase(VHR) | ChEMBL. | 11563920 |
IC50 (binding) | > 100 uM | Inhibitory activity against PTP-S2 phosphatase | ChEMBL. | 11563920 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.