Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | glucokinase | Starlite/ChEMBL | References |
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Brugia malayi | Hexokinase family protein | glucokinase | 465 aa | 473 aa | 29.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hexokinase, putative | 0.0192 | 0.0838 | 0.5 |
Brugia malayi | Trypsin family protein | 0.033 | 0.2722 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.2722 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.033 | 0.2722 | 0.2056 |
Leishmania major | hexokinase, putative | 0.0192 | 0.0838 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.033 | 0.2722 | 0.2056 |
Schistosoma mansoni | hypothetical protein | 0.033 | 0.2722 | 0.2056 |
Echinococcus multilocularis | Mastin | 0.033 | 0.2722 | 0.2056 |
Plasmodium vivax | hexokinase, putative | 0.0192 | 0.0838 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.033 | 0.2722 | 0.2056 |
Trypanosoma cruzi | hexokinase, putative | 0.0192 | 0.0838 | 0.5 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.033 | 0.2722 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.0192 | 0.0838 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0192 | 0.0838 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.033 | 0.2722 | 0.2056 |
Loa Loa (eye worm) | hexokinase | 0.0192 | 0.0838 | 0.3078 |
Echinococcus granulosus | enteropeptidase | 0.033 | 0.2722 | 0.2056 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.033 | 0.2722 | 0.2056 |
Onchocerca volvulus | 0.033 | 0.2722 | 1 | |
Brugia malayi | Trypsin family protein | 0.033 | 0.2722 | 1 |
Onchocerca volvulus | 0.033 | 0.2722 | 1 | |
Brugia malayi | Trypsin family protein | 0.033 | 0.2722 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.033 | 0.2722 | 0.2056 |
Toxoplasma gondii | hexokinase | 0.0192 | 0.0838 | 0.5 |
Onchocerca volvulus | 0.033 | 0.2722 | 1 | |
Brugia malayi | Trypsin-like protease protein 5 | 0.033 | 0.2722 | 1 |
Plasmodium falciparum | hexokinase | 0.0192 | 0.0838 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.033 | 0.2722 | 0.2056 |
Onchocerca volvulus | 0.033 | 0.2722 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.0192 | 0.0838 | 0.3078 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.033 | 0.2722 | 0.2056 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.033 | 0.2722 | 0.2056 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.033 | 0.2722 | 0.2056 |
Treponema pallidum | hexokinase (hxk) | 0.0192 | 0.0838 | 0.5 |
Onchocerca volvulus | 0.033 | 0.2722 | 1 | |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.033 | 0.2722 | 0.2056 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.033 | 0.2722 | 0.2056 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.033 | 0.2722 | 0.2056 |
Brugia malayi | Trypsin family protein | 0.033 | 0.2722 | 1 |
Onchocerca volvulus | 0.033 | 0.2722 | 1 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.033 | 0.2722 | 0.2056 |
Entamoeba histolytica | hexokinase 2 | 0.0192 | 0.0838 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.033 | 0.2722 | 0.2056 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.033 | 0.2722 | 0.2056 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.033 | 0.2722 | 0.2056 |
Echinococcus multilocularis | enteropeptidase | 0.033 | 0.2722 | 0.2056 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.033 | 0.2722 | 0.2056 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.2722 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.033 | 0.2722 | 0.2056 |
Mycobacterium ulcerans | hypothetical protein | 0.033 | 0.2722 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.2722 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.033 | 0.2722 | 0.2056 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.033 | 0.2722 | 0.2056 |
Echinococcus granulosus | Mastin | 0.033 | 0.2722 | 0.2056 |
Trypanosoma brucei | hexokinase | 0.0192 | 0.0838 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.2722 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.033 | 0.2722 | 0.2056 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.033 | 0.2722 | 0.2056 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.2722 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.033 | 0.2722 | 0.2056 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.2722 | 1 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.033 | 0.2722 | 0.2056 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.033 | 0.2722 | 0.2056 |
Loa Loa (eye worm) | trypsin family protein | 0.033 | 0.2722 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0192 | 0.0838 | 0.3078 |
Leishmania major | hexokinase, putative | 0.0192 | 0.0838 | 0.5 |
Brugia malayi | hypothetical protein | 0.033 | 0.2722 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0192 | 0.0838 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.2722 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.033 | 0.2722 | 0.2056 |
Schistosoma mansoni | hypothetical protein | 0.033 | 0.2722 | 0.2056 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | < 14 microL/min/mg | Intrinsic clearance in human liver microsomes at 1 uM after 30 mins in presence of NADPH | ChEMBL. | 24405213 |
EC50 (binding) | > 12.5 uM | Induction of GK translocation from nucleus to cytoplasm of mouse hepatocytes preincubated for 20 mins followed by glucose challenge measured after 40 mins by Hoechst 33342 staining-based assay | ChEMBL. | 24405213 |
IC50 (binding) | = 0.484 uM | Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled GK measured after 2 to 4 hrs by Alpha Screen assay | ChEMBL. | 24405213 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.