Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | Starlite/ChEMBL | References |
Homo sapiens | anaplastic lymphoma receptor tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | TK/ALK protein kinase | Get druggable targets OG5_132231 | All targets in OG5_132231 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_132231 | All targets in OG5_132231 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132231 | All targets in OG5_132231 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0045 | 0.0348 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0045 | 0.0348 | 1 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0045 | 0.0348 | 0.0371 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0045 | 0.0348 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0285 | 0.7662 | 0.7662 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0045 | 0.0348 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0045 | 0.0348 | 1 |
Onchocerca volvulus | 0.0337 | 0.9234 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.9381 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0045 | 0.0348 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0045 | 0.0348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0317 | 0.8615 | 0.9184 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.0045 | 0.0348 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0045 | 0.0348 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0045 | 0.0348 | 1 |
Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.0045 | 0.0348 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0045 | 0.0348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.6583 | 0.7018 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0045 | 0.0348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0317 | 0.8615 | 0.9184 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0045 | 0.0348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0317 | 0.8615 | 0.9184 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0045 | 0.0348 | 1 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.0285 | 0.7659 | 0.8165 |
Onchocerca volvulus | 0.0054 | 0.0619 | 0.0671 | |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0045 | 0.0348 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9 uM | Inhibition of NPM/ALK L1196M mutant (unknown origin) transfected in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by [3H]-thymidine incorporation assay | ChEMBL. | 24468632 |
IC50 (binding) | = 10 uM | Inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using ARDIYRASFFRKGGCAMLPVK as substrate preincubated for 10 mins followed by ATP addition measured after 15 mins by ELISA | ChEMBL. | 24468632 |
IC50 (binding) | = 17 uM | Inhibition of NPM/ALK (unknown origin) transfected in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by [3H]-thymidine incorporation assay | ChEMBL. | 24468632 |
IC50 (ADMET) | > 25 uM | Cytotoxicity against mouse BAF3 cells assessed as growth inhibition after 72 hrs by [3H]-thymidine incorporation assay | ChEMBL. | 24468632 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.