Detailed information for compound 183500

Basic information

Technical information
  • TDR Targets ID: 183500
  • Name: 4-(2,5-diphenylfuran-3-yl)morpholine
  • MW: 305.37 | Formula: C20H19NO2
  • H donors: 0 H acceptors: 0 LogP: 4.06 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)c1cc(c(o1)c1ccccc1)N1CCOCC1
  • InChi: 1S/C20H19NO2/c1-3-7-16(8-4-1)19-15-18(21-11-13-22-14-12-21)20(23-19)17-9-5-2-6-10-17/h1-10,15H,11-14H2
  • InChiKey: UIZBMSXOYPJXSV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2,5-diphenyl-3-furyl)morpholine
  • 4-[2,5-di(phenyl)furan-3-yl]morpholine
  • 4-[2,5-di(phenyl)-3-furyl]morpholine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 4A, cAMP-specific Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium parvum membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative Get druggable targets OG5_128242 All targets in OG5_128242
Neospora caninum cAMP-specific phosphodiesterase, putative Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing Get druggable targets OG5_128242 All targets in OG5_128242
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0091 0.5
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0271 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0271 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0091 0.0225
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0271 0.0668
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0091 0.5
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0112 0.4052 0.3997
Plasmodium vivax phosphodiesterase gamma, putative 0.0014 0.0091 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0091 0.3364
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0098 0.3503 0.8645
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0271 0.0527
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0091 0.3364
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0091 0.0225
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0014 0.0091 0.3364
Plasmodium falciparum phosphodiesterase delta, putative 0.0014 0.0091 0.5
Loa Loa (eye worm) PDE1B protein 0.0014 0.0091 0.0225
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0014 0.0091 0.3364
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0014 0.0091 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0014 0.0091 0.3364
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0271 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0112 0.4052 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0091 0.0225
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0112 0.4052 0.3997
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0271 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0098 0.3503 0.3443
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0098 0.3503 0.3443
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0091 0.0225
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0014 0.0091 0.3364
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0091 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0271 0.0181
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0271 0.0181
Leishmania major hypothetical protein, conserved 0.0094 0.334 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0091 0.3364
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0091 0.0225
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0091 0.0225
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0014 0.0091 0.3364
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0271 0.0668
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0271 0.5
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0098 0.3503 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0259 1 1
Giardia lamblia GTOR 0.0018 0.0271 0.0454
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0091 0.3364
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0091 0.0225
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0091 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0014 0.0091 0.3364
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0271 0.0578
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0271 0.0553
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0271 0.0578
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0014 0.0091 0.0225
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0271 0.0578
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0271 0.0181
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0271 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0112 0.4052 0.3997
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0271 0.0527
Loa Loa (eye worm) hypothetical protein 0.0014 0.0091 0.0225
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0271 0.0578
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0014 0.0091 0.5
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0091 0.3364
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0271 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0091 0.0225
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0014 0.0091 0.3364
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Trypanosoma cruzi hypothetical protein, conserved 0.0091 0.32 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0091 0.0225
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.0014 0.0091 0.5
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0091 0.3364
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0091 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0091 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0091 0.0225
Loa Loa (eye worm) hypothetical protein 0.0014 0.0091 0.0225
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0091 0.3364
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0271 0.0553
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0091 0.3364
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0112 0.4052 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0091 0.0225
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0091 0.0225
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0271 0.0454
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0091 0.3364
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0112 0.4052 0.3997
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0091 0.3364
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0271 0.0668
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0091 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0014 0.0091 0.5
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0271 0.0454
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0091 0.3364
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0271 0.0553
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0091 0.5
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0271 0.0553
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0091 0.0225
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0271 0.0553
Loa Loa (eye worm) hypothetical protein 0.0014 0.0091 0.0225
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0271 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0271 0.0181
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0112 0.4052 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0271 0.0578
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0014 0.0091 0.3364
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0091 0.3364
Loa Loa (eye worm) hypothetical protein 0.0112 0.4052 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.3 uM PDE4A activity assessed using human recombinant purified GST-PDE4A248 ChEMBL. 10091677
IC50 (binding) = 2.3 uM PDE4A activity assessed using human recombinant purified GST-PDE4A248 ChEMBL. 10091677

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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