Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Homo sapiens | ADAM metallopeptidase domain 17 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma japonicum | ko:K06059 a disintegrin and metalloproteinase domain 17, putative | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Brugia malayi | Disintegrin family protein | ADAM metallopeptidase domain 17 | 824 aa | 724 aa | 27.4 % |
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Matrilysin homolog | 0.0117 | 0.1068 | 1 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0105 | 0.0835 | 0.6517 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0191 | 0.2582 | 0.7318 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0223 | 0.3222 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0557 | 1 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0127 | 0.1281 | 0.1562 |
Trichomonas vaginalis | hypothetical protein | 0.0557 | 1 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0117 | 0.1068 | 0.1302 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0105 | 0.0835 | 0.2066 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0557 | 1 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.0075 | 0.0214 | 0.1666 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0557 | 1 | 0.5 |
Echinococcus multilocularis | adam 17 protease | 0.0223 | 0.3222 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0557 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0557 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0557 | 1 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0557 | 1 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0117 | 0.1068 | 1 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.014 | 0.1537 | 0.2942 |
Brugia malayi | Matrixin family protein | 0.0127 | 0.1281 | 1 |
Echinococcus granulosus | adam 17 protease | 0.0245 | 0.3673 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0191 | 0.2582 | 0.6156 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.8203 | 1 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.014 | 0.1537 | 0.2474 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | nM | Compound was tested for the inhibition of human recombinant tumor necrosis factor-alpha converting enzyme catalytic domain was expressed with its prodomain in baculoviral infected insect (SF9) cells; not determined | ChEMBL. | 12951101 |
IC50 (binding) | 0 nM | Compound was tested for the inhibition of human recombinant tumor necrosis factor-alpha converting enzyme catalytic domain was expressed with its prodomain in baculoviral infected insect (SF9) cells; not determined | ChEMBL. | 12951101 |
IC50 (binding) | = 17 nM | In vitro inhibition of matrix metalloprotease-13. | ChEMBL. | 12951101 |
IC50 (binding) | = 17 nM | In vitro inhibition of matrix metalloprotease-13. | ChEMBL. | 12951101 |
IC50 (binding) | = 830 nM | In vitro inhibition of matrix metalloprotease-1. | ChEMBL. | 12951101 |
IC50 (binding) | = 830 nM | In vitro inhibition of matrix metalloprotease-1. | ChEMBL. | 12951101 |
IC50 (functional) | = 0.3 uM | Inhibition of Tumor necrosis factor-alpha (TNF-alpha) release in human whole blood | ChEMBL. | 12951101 |
IC50 (functional) | = 0.3 uM | Inhibition of Tumor necrosis factor-alpha (TNF-alpha) release in human whole blood | ChEMBL. | 12951101 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.