Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 2, subfamily D, polypeptide 6 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 9 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | cytochrome P450, family 2, subfamily C, polypeptide 9 | 490 aa | 441 aa | 21.8 % |
Brugia malayi | cytochrome P450 | cytochrome P450, family 2, subfamily D, polypeptide 6 | 497 aa | 425 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | histone deacetylase 7 | 0.0799 | 0.6567 | 0.6567 |
Schistosoma mansoni | tyrosine kinase | 0.0155 | 0.0599 | 0.0574 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0291 | 0.1862 | 0.184 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0492 | 0.3726 | 0.3708 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0799 | 0.6567 | 0.4528 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0811 | 0.668 | 0.668 |
Loa Loa (eye worm) | hypothetical protein | 0.0492 | 0.3726 | 0.3708 |
Plasmodium vivax | histone deacetylase, putative | 0.0799 | 0.6567 | 0.4528 |
Echinococcus granulosus | histone deacetylase 6 | 0.0799 | 0.6567 | 0.6558 |
Trypanosoma brucei | histone deacetylase 3 | 0.0799 | 0.6567 | 0.4528 |
Echinococcus granulosus | histone deacetylase 6 | 0.0811 | 0.668 | 0.6671 |
Echinococcus granulosus | histone deacetylase 7 | 0.0799 | 0.6567 | 0.6558 |
Schistosoma mansoni | tyrosine kinase | 0.0156 | 0.0614 | 0.0589 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0156 | 0.0614 | 0.0589 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.212 | 0.2099 |
Schistosoma mansoni | tyrosine kinase | 0.0155 | 0.0599 | 0.0574 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0799 | 0.6567 | 0.4528 |
Echinococcus multilocularis | insulin receptor | 0.0093 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0291 | 0.1862 | 0.184 |
Loa Loa (eye worm) | histone deacetylase | 0.0799 | 0.6567 | 0.6558 |
Schistosoma mansoni | tyrosine kinase | 0.0155 | 0.0599 | 0.0574 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0799 | 0.6567 | 0.6558 |
Echinococcus granulosus | histone deacetylase 8 | 0.0492 | 0.3726 | 0.3708 |
Schistosoma mansoni | tyrosine kinase | 0.0156 | 0.0614 | 0.0589 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0799 | 0.6567 | 0.4528 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0799 | 0.6567 | 0.4528 |
Brugia malayi | Histone deacetylase family protein | 0.0799 | 0.6567 | 0.6558 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0291 | 0.1862 | 0.184 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0799 | 0.6567 | 0.6558 |
Echinococcus granulosus | histone deacetylase 6 | 0.0799 | 0.6567 | 0.6558 |
Trypanosoma brucei | histone deacetylase 4 | 0.0799 | 0.6567 | 0.4528 |
Echinococcus multilocularis | histone deacetylase | 0.0799 | 0.6567 | 0.6567 |
Schistosoma mansoni | tyrosine kinase | 0.0291 | 0.1862 | 0.184 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0492 | 0.3726 | 0.3708 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0291 | 0.1862 | 0.1862 |
Brugia malayi | Histone deacetylase family protein | 0.0799 | 0.6567 | 0.6558 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0811 | 0.668 | 0.6671 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0799 | 0.6567 | 0.6567 |
Brugia malayi | histone deacetylase 11 | 0.0492 | 0.3726 | 0.3708 |
Echinococcus granulosus | histone deacetylase | 0.0799 | 0.6567 | 0.6558 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0093 | 0.0027 | 0.0027 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0799 | 0.6567 | 0.4528 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0799 | 0.6567 | 0.6558 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0492 | 0.3726 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0799 | 0.6567 | 0.6567 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0156 | 0.0614 | 0.0589 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0492 | 0.3726 | 0.3726 |
Trypanosoma brucei | histone deacetylase, putative | 0.0799 | 0.6567 | 0.4528 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0156 | 0.0614 | 0.0614 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0492 | 0.3726 | 0.3708 |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 0.2007 | 0.1985 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 54 % | Activation of CYP3A4 (unknown origin) at 10 uM by PXR reporter gene assay | ChEMBL. | 24266880 |
IC50 (ADMET) | > 10000 nM | Toxicity in human HuH7 cells assessed as effect on GAPDH mRNA level | ChEMBL. | 24266880 |
IC50 (ADMET) | > 10 uM | Inhibition of CYP2C9 in human liver microsomes | ChEMBL. | 24266880 |
IC50 (ADMET) | > 10 uM | Inhibition of CYP2D6 in human liver microsomes | ChEMBL. | 24266880 |
IC50 (ADMET) | > 10 uM | Inhibition of CYP3A4 in human liver microsomes | ChEMBL. | 24266880 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24266880 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.