Detailed information for compound 1839040

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 654.833 | Formula: C37H54N2O8
  • H donors: 2 H acceptors: 0 LogP: 4.39 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC1(C)O[C@@H]2[C@H](O1)OC([C@H]2OCc1ccccc1)CNCCCCCCCNCC1O[C@H]2[C@@H]([C@H]1OCc1ccccc1)OC(O2)(C)C
  • InChi: 1S/C37H54N2O8/c1-36(2)44-32-30(40-24-26-16-10-8-11-17-26)28(42-34(32)46-36)22-38-20-14-6-5-7-15-21-39-23-29-31(41-25-27-18-12-9-13-19-27)33-35(43-29)47-37(3,4)45-33/h8-13,16-19,28-35,38-39H,5-7,14-15,20-25H2,1-4H3/t28?,29?,30-,31+,32+,33-,34+,35-
  • InChiKey: GWOKPLIRIZBPPP-RJYKELPLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii heat shock protein 90, putative 0.0295 0.0522 0.1258
Trypanosoma cruzi heat shock protein 85, putative 0.0295 0.0522 0.0506
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0295 0.0522 1
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0024 0.0458
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0109 0.2094
Echinococcus granulosus pyruvate kinase 0.0028 0.0017 0.0006
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0683 0.1257 0.1252
Brugia malayi heat shock protein 90 0.0295 0.0522 0.0511
Leishmania major heat shock protein 83-1 0.0295 0.0522 0.0506
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0187 0.3578
Leishmania major heat shock protein 83-1 0.0295 0.0522 0.0506
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0295 0.0522 0.5
Mycobacterium tuberculosis Probable two component sensor kinase 0.0295 0.0522 1
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0295 0.0522 1
Leishmania major heat shock protein 83-1 0.0295 0.0522 0.0506
Leishmania major heat shock protein 83-1 0.0295 0.0522 0.0506
Brugia malayi hypothetical protein 0.003 0.0021 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0109 0.2094
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0295 0.0522 0.0506
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0047 0.0036
Schistosoma mansoni heat shock protein 0.0295 0.0522 0.0511
Loa Loa (eye worm) hypothetical protein 0.0025 0.0011 0.001
Leishmania major DNA topoisomerase ii 0.0295 0.0522 0.0506
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0047 0.0042
Mycobacterium tuberculosis Possible two component sensor kinase 0.0295 0.0522 1
Leishmania major heat shock protein 83-1 0.0295 0.0522 0.0506
Schistosoma mansoni endoplasmin 0.0295 0.0522 0.0511
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0047 0.0036
Entamoeba histolytica DNA topoisomerase II, putative 0.0295 0.0522 1
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0187 0.0176
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0137 0.0126
Leishmania major heat shock protein 83-1 0.0295 0.0522 0.0506
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0024 0.0458
Leishmania major heat shock protein 83-1 0.0295 0.0522 0.0506
Brugia malayi Calcitonin receptor-like protein seb-1 0.0079 0.0114 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0049 0.0947
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.1854 0.3472 0.3461
Mycobacterium ulcerans putative regultory protein 0.0295 0.0522 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0118 0.0187 0.327
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0024 0.0458
Trypanosoma brucei heat shock protein, putative 0.0295 0.0522 0.0506
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.1854 0.3472 0.3461
Plasmodium vivax hypothetical protein, conserved 0.0295 0.0522 1
Trypanosoma brucei heat shock protein 90, putative 0.0295 0.0522 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0109 0.2094
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0109 0.2094
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0295 0.0522 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0028 0.0017 0.0006
Brugia malayi Pyruvate kinase, muscle isozyme 0.0028 0.0017 0.0006
Trichomonas vaginalis pyruvate kinase, putative 0.0028 0.0017 0.0322
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0109 0.2094
Mycobacterium ulcerans two component sensor kinase MprB 0.0295 0.0522 1
Chlamydia trachomatis DNA gyrase subunit B 0.0295 0.0522 1
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0295 0.0522 0.0506
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0137 0.012
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0187 0.3578
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0295 0.0522 1
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0295 0.0522 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0109 0.2094
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0137 0.2624
Loa Loa (eye worm) latrophilin receptor protein 2 0.0025 0.0011 0.001
Plasmodium vivax endoplasmin, putative 0.0295 0.0522 1
Plasmodium vivax heat shock protein 86, putative 0.0295 0.0522 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0137 0.2624
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0024 0.0018
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0295 0.0522 0.0511
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0137 0.2624
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0295 0.0522 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0089 0.0131 0.0126
Mycobacterium leprae Probable two-component sensor kinase 0.0295 0.0522 1
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0295 0.0522 0.0506
Entamoeba histolytica hypothetical protein 0.003 0.0021 0.0402
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0024 0.0458
Leishmania major heat shock protein 83-1 0.0295 0.0522 0.0506
Echinococcus multilocularis pyruvate kinase 0.0028 0.0017 0.0011
Giardia lamblia Heat shock protein HSP 90-alpha 0.0295 0.0522 1
Loa Loa (eye worm) heat shock protein 90 0.0295 0.0522 0.0521
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0187 0.3578
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0024 0.014
Echinococcus multilocularis geminin 0.0164 0.0273 0.0268
Brugia malayi 6-phosphofructokinase 0.0118 0.0187 0.0176
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0077 0.0109 0.2094
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0295 0.0522 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0137 0.2624
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0137 0.012
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0137 0.0126
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.1854 0.3472 0.3461
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0109 0.2094
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0073 0.1396
Trypanosoma brucei heat shock protein, putative 0.0295 0.0522 0.0506
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0047 0.0036
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0295 0.0522 1
Leishmania major heat shock protein 83-1 0.0295 0.0522 0.0506
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0187 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0109 0.2094
Echinococcus granulosus pyruvate kinase 0.0028 0.0017 0.0006
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0024 0.014
Trypanosoma brucei polo-like protein kinase 0.0092 0.0137 0.012
Echinococcus granulosus neuropeptide s receptor 0.0347 0.0621 0.0611
Trypanosoma brucei heat shock protein, putative 0.0295 0.0522 0.0506
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0295 0.0522 1
Trypanosoma brucei DNA topoisomerase ii 0.0295 0.0522 0.0506
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0187 0.3578
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0047 0.0047
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0025 0.0011 0.0006
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0077 0.0109 0.2094
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0295 0.0522 1
Echinococcus granulosus heat shock protein 0.0295 0.0522 0.0511
Brugia malayi Endoplasmin precursor 0.0295 0.0522 0.0511
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0024 0.014
Giardia lamblia Kinase, PLK 0.0092 0.0137 0.2379
Trichomonas vaginalis heat shock protein, putative 0.0295 0.0522 1
Plasmodium falciparum DNA gyrase subunit B 0.0295 0.0522 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0187 0.017
Mycobacterium ulcerans two component regulator - sensor kinase 0.0295 0.0522 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0295 0.0522 0.0506
Trypanosoma brucei heat shock protein, putative 0.0295 0.0522 0.0506
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0295 0.0522 0.1258
Schistosoma mansoni DNA topoisomerase II 0.0295 0.0522 0.0511
Echinococcus multilocularis 6 phosphofructokinase 0.0118 0.0187 0.0181
Schistosoma mansoni hypothetical protein 0.0054 0.0066 0.0055
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0047 0.0036
Plasmodium falciparum endoplasmin, putative 0.0295 0.0522 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0137 0.2624
Schistosoma mansoni hypothetical protein 0.0164 0.0273 0.0263
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0295 0.0522 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0137 0.012
Schistosoma mansoni pyruvate kinase 0.0028 0.0017 0.0006
Echinococcus multilocularis pyruvate kinase 0.0028 0.0017 0.0011
Loa Loa (eye worm) pyruvate kinase 0.0028 0.0017 0.0016
Plasmodium vivax DNA gyrase subunit B, putative 0.0295 0.0522 1
Trichomonas vaginalis sensor histidine kinase, putative 0.0295 0.0522 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0187 0.017
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0295 0.0522 1
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0295 0.0522 1
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0049 0.0947
Leishmania major heat shock protein 83-1 0.0295 0.0522 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0109 0.2094
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.003 0.0021 0.001
Giardia lamblia NADPH oxidoreductase, putative 0.0077 0.0109 0.1831
Brugia malayi Probable DNA topoisomerase II 0.0295 0.0522 0.0511
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0295 0.0522 0.1258
Echinococcus granulosus geminin 0.0164 0.0273 0.0263
Plasmodium falciparum heat shock protein 90 0.0295 0.0522 1
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0109 0.2094
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0295 0.0522 1
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0024 0.0018
Leishmania major heat shock protein 83-1 0.0295 0.0522 0.0506
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0295 0.0522 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0025 0.0011 0.0006
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0295 0.0522 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0295 0.0522 1
Schistosoma mansoni pyruvate dehydrogenase 0.5007 0.9442 0.9441
Plasmodium vivax DNA topoisomerase II, putative 0.0295 0.0522 1
Schistosoma mansoni lipoxygenase 0.0089 0.0131 0.012
Leishmania major mitochondrial DNA topoisomerase II 0.0295 0.0522 0.0506
Schistosoma mansoni heat shock protein 0.0295 0.0522 0.0511
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0187 0.3578
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0295 0.0522 1
Brugia malayi phosphofructokinase 0.0118 0.0187 0.0176
Echinococcus multilocularis heat shock protein 90 0.0295 0.0522 0.0517
Loa Loa (eye worm) pyruvate kinase 0.0028 0.0017 0.0016
Leishmania major hypothetical protein, conserved 0.0295 0.0522 0.0506
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0079 0.0114 0.0113
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0295 0.0522 1
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0077 0.0109 0.2094
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0109 0.2094
Brugia malayi latrophilin 2 splice variant baaae 0.0054 0.0066 0.0055
Mycobacterium tuberculosis Conserved protein 0.0295 0.0522 1
Leishmania major heat shock protein 83-1 0.0295 0.0522 0.0506
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0295 0.0522 1
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0295 0.0522 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0016
Echinococcus multilocularis neuropeptide s receptor 0.0347 0.0621 0.0616
Schistosoma mansoni transcription factor LCR-F1 0.003 0.0021 0.001
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0295 0.0522 1
Schistosoma mansoni hypothetical protein 0.003 0.0021 0.001
Trypanosoma cruzi DNA topoisomerase II, putative 0.0295 0.0522 0.0506
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0137 0.2624
Mycobacterium ulcerans 6-phosphofructokinase 0.0118 0.0187 0.3364
Plasmodium falciparum DNA topoisomerase 2 0.0295 0.0522 1
Entamoeba histolytica heat shock protein 90, putative 0.0295 0.0522 1
Leishmania major heat shock protein 83-1 0.0295 0.0522 0.0506
Giardia lamblia NADPH oxidoreductase, putative 0.0077 0.0109 0.1831
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0118 0.0187 0.3364
Schistosoma mansoni kinase 0.0047 0.0052 0.0041
Chlamydia trachomatis DNA gyrase subunit B 0.0295 0.0522 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0137 0.2624
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0047 0.0042
Loa Loa (eye worm) pyruvate kinase 0.0028 0.0017 0.0016
Loa Loa (eye worm) endoplasmin 0.0295 0.0522 0.0521
Schistosoma mansoni pyruvate dehydrogenase 0.5007 0.9442 0.9441
Echinococcus granulosus heat shock protein 90 0.0295 0.0522 0.0511
Trypanosoma brucei heat shock protein, putative 0.0295 0.0522 0.0506
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0024 0.0458
Toxoplasma gondii heat shock protein HSP90 0.0295 0.0522 0.1258
Leishmania major heat shock protein 83-1 0.0295 0.0522 0.0506
Trichomonas vaginalis endoplasmin, putative 0.0295 0.0522 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0118 0.0187 0.3364
Loa Loa (eye worm) phosphofructokinase 0.0118 0.0187 0.0186
Toxoplasma gondii DNA topoisomerase 2, putative 0.0295 0.0522 0.1258
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0295 0.0522 0.0511
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0295 0.0522 0.0511
Mycobacterium leprae Probable two component sensor kinase MprB 0.0295 0.0522 1
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0109 0.2094
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0187 0.3578
Echinococcus multilocularis heat shock protein 0.0295 0.0522 0.0517
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0295 0.0522 0.0506
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0295 0.0522 1
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0295 0.0522 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0295 0.0522 0.0506
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0295 0.0522 0.0506
Loa Loa (eye worm) TOPoisomerase family member 0.0295 0.0522 0.0521
Schistosoma mansoni lipoxygenase 0.0062 0.0081 0.007
Loa Loa (eye worm) hypothetical protein 0.0054 0.0066 0.0066
Schistosoma mansoni endoplasmin 0.0295 0.0522 0.0511
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0024 0.0458
Mycobacterium ulcerans DNA gyrase subunit B 0.0295 0.0522 1
Schistosoma mansoni hypothetical protein 0.0164 0.0273 0.0263
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0047 0.0036
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0024 0.014
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0079 0.0114 0.0103
Trypanosoma brucei heat shock protein, putative 0.0295 0.0522 0.0506
Echinococcus multilocularis neuropeptide receptor A26 0.0347 0.0621 0.0616
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0089 0.0131 0.012
Entamoeba histolytica hypothetical protein 0.003 0.0021 0.0402
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0295 0.0522 1
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0187 0.3578
Entamoeba histolytica pyruvate kinase, putative 0.002 0.0001 0.0014
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0295 0.0522 1
Leishmania major heat shock protein 83-1 0.0295 0.0522 0.0506
Trypanosoma brucei Heat shock protein 83, putative 0.0295 0.0522 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0109 0.2094
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.1854 0.3472 0.8609
Giardia lamblia Pms1-like protein 0.0295 0.0522 1
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0295 0.0522 1
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0295 0.0522 1
Trichomonas vaginalis DNA topoisomerase II, putative 0.0295 0.0522 1
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0295 0.0522 0.0506
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0024 0.014
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0137 0.2379
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0295 0.0522 1
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0295 0.0522 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.003 0.0021 0.0015
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0024 0.0018
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0024 0.014
Echinococcus granulosus 6 phosphofructokinase 0.0118 0.0187 0.0176
Trypanosoma cruzi heat shock protein 85, putative 0.0295 0.0522 0.0506
Trypanosoma cruzi heat shock protein 85, putative 0.0295 0.0522 0.0506
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0295 0.0522 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0295 0.0522 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0137 0.0131
Trichomonas vaginalis receptor histidine kinase, putative 0.0295 0.0522 1
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0295 0.0522 0.0517
Trichomonas vaginalis heat shock protein, putative 0.0295 0.0522 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.0522 0.0521
Leishmania major heat shock protein 83-1 0.0295 0.0522 0.0506
Trypanosoma cruzi heat shock protein 90, putative 0.0295 0.0522 0.0506
Leishmania major heat shock protein 83-1 0.0295 0.0522 0.0506
Loa Loa (eye worm) hypothetical protein 0.0079 0.0114 0.0113
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0137 0.0126
Trichomonas vaginalis pyruvate kinase, putative 0.0028 0.0017 0.0322
Trypanosoma brucei heat shock protein 90, putative 0.0295 0.0522 0.0506
Entamoeba histolytica heat shock protein 90, putative 0.0295 0.0522 1
Schistosoma mansoni pyruvate kinase 0.0028 0.0017 0.0006
Loa Loa (eye worm) hypothetical protein 0.0295 0.0522 0.0521
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0187 0.0186
Giardia lamblia NADPH oxidoreductase, putative 0.0077 0.0109 0.1831
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0024 0.014
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0295 0.0522 1
Leishmania major ATP-dependent phosphofructokinase 0.0118 0.0187 0.017
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0024 0.0458
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0187 0.0186
Echinococcus granulosus neuropeptide receptor A26 0.0347 0.0621 0.0611
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.2149 0.4031 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0137 0.2624
Brugia malayi 6-phosphofructokinase 0.0118 0.0187 0.0176
Entamoeba histolytica hypothetical protein 0.003 0.0021 0.0402
Trypanosoma brucei heat shock protein, putative 0.0295 0.0522 0.0506
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0295 0.0522 0.5
Entamoeba histolytica hypothetical protein 0.003 0.0021 0.0402
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0047 0.0036
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0295 0.0522 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0137 0.0136
Echinococcus multilocularis GPCR, family 2 0.0025 0.0011 0.0006
Trichomonas vaginalis receptor histidine kinase, putative 0.0295 0.0522 1
Trypanosoma brucei heat shock protein, putative 0.0295 0.0522 0.0506
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0024 0.0458
Trypanosoma cruzi heat shock protein 90, putative 0.0295 0.0522 0.0506

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antifilarial activity against Brugia malayi isolated from jird assessed as motility at 100 uM after 24 hr by dissecting microscopy ChEMBL. No reference
Activity (binding) = 58 % Stimulation of Setaria cervi GST cytosolic form using CDNB as substrate at 100 uM after 10 min by spectrophotometric analysis relative to control ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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