Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sumo-1-activating enzyme E1a | 0.0124 | 0.0206 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.0206 | 0.0206 |
Echinococcus granulosus | ubiquitin modifier activating enzyme 6 | 0.0221 | 0.0701 | 0.0557 |
Trypanosoma brucei | ubiquitin-activating enzyme E1, putative | 0.0145 | 0.0315 | 0.0606 |
Echinococcus multilocularis | ubiquitin modifier activating enzyme 6 | 0.0221 | 0.0701 | 0.0557 |
Schistosoma mansoni | ubiquitin-activating enzyme E1 | 0.0189 | 0.054 | 0.0393 |
Echinococcus granulosus | SUMO activating enzyme subunit 1 | 0.0124 | 0.0206 | 0.0054 |
Plasmodium vivax | ubiquitin-activating enzyme E1C, putative | 0.0638 | 0.2833 | 1 |
Trypanosoma cruzi | ubiquitin-activating enzyme E1, putative | 0.0145 | 0.0315 | 0.0701 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0184 | 0.0514 | 0.0723 |
Toxoplasma gondii | ThiF family protein | 0.0114 | 0.0153 | 0.0153 |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.0221 | 0.0701 | 0.0701 |
Trypanosoma cruzi | ubiquitin-activating enzyme E1, putative | 0.0145 | 0.0315 | 0.0701 |
Plasmodium falciparum | SUMO-activating enzyme subunit 1 | 0.0124 | 0.0206 | 0.0726 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1c, putative | 0.0184 | 0.0514 | 0.0723 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0153 | 0.0153 |
Brugia malayi | ThiF family protein | 0.0124 | 0.0206 | 0.0054 |
Giardia lamblia | Ubiquitin-conjugating enzyme E1 | 0.0145 | 0.0315 | 0.5 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1 X, putative | 0.0115 | 0.0161 | 0.0227 |
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.0638 | 0.2833 | 1 |
Leishmania major | ubiquitin-activating enzyme e1, putative | 0.0145 | 0.0315 | 0.0606 |
Trypanosoma cruzi | NEDD8-activating enzyme E1 regulatory subunit, putative | 0.0114 | 0.0153 | 0.0101 |
Schistosoma mansoni | clathrin coat associated protein ap-50 | 0.0159 | 0.0386 | 0.0237 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0114 | 0.0153 | 0.0215 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0184 | 0.0514 | 0.0723 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.1475 | 0.7106 | 1 |
Trypanosoma brucei | ubiquitin-activating enzyme E1, putative | 0.012 | 0.0187 | 0.0127 |
Toxoplasma gondii | hypothetical protein | 0.0124 | 0.0206 | 0.0206 |
Schistosoma mansoni | clathrin coat associated protein ap-50 | 0.0159 | 0.0386 | 0.0237 |
Echinococcus granulosus | ubiquitin modifier activating enzyme 1 | 0.0221 | 0.0701 | 0.0557 |
Leishmania major | ubiquitin-activating enzyme e1, putative | 0.012 | 0.0187 | 0.0127 |
Entamoeba histolytica | ubiquitin-activating enzyme E1 1, putative | 0.0184 | 0.0514 | 0.0514 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0111 | 0.0137 | 0.0193 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0114 | 0.0153 | 0.0215 |
Leishmania major | ubiquitin activating enzyme, putative | 0.0638 | 0.2833 | 1 |
Plasmodium vivax | ubiquitin activating enzyme, putative | 0.0124 | 0.0206 | 0.0726 |
Loa Loa (eye worm) | ube1-prov protein | 0.0221 | 0.0701 | 0.0701 |
Entamoeba histolytica | ThiF family protein | 0.0114 | 0.0153 | 0.0153 |
Echinococcus multilocularis | SUMO activating enzyme subunit 1 | 0.0124 | 0.0206 | 0.0054 |
Echinococcus multilocularis | ubiquitin modifier activating enzyme 1 | 0.0221 | 0.0701 | 0.0557 |
Brugia malayi | ube1-prov protein | 0.0221 | 0.0701 | 0.0557 |
Plasmodium falciparum | ubiquitin-activating enzyme E1 | 0.0221 | 0.0701 | 0.2474 |
Plasmodium falciparum | NEDD8-activating enzyme E1 catalytic subunit, putative | 0.0638 | 0.2833 | 1 |
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.0638 | 0.2833 | 1 |
Trypanosoma brucei | NEDD8 activating enzyme subunit, putative | 0.0638 | 0.2833 | 1 |
Trichomonas vaginalis | molybdopterin biosynthesis moeb protein, putative | 0.0638 | 0.2833 | 0.3986 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-log(inh/100-inh) (functional) | = 0.0871 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv at 6.25 ug/ml | ChEMBL. | No reference |
IZ (functional) | = 14 mm | Antibacterial activity against Escherichia coli by two-fold serial dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.