Detailed view for Smp_026540.2

Basic information

TDR Targets ID: 284170
Schistosoma mansoni, clathrin coat associated protein ap-50
Source Database / ID:  GeneDB

pI: 6.3112 | Length (AA): 1085 | MW (Da): 122571 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00899   ThiF family
PF00928   Adaptor complexes medium subunit family
PF10585   Ubiquitin-activating enzyme active site
PF16190   Ubiquitin-activating enzyme E1 FCCH domain
PF16191   Ubiquitin-activating enzyme E1 four-helix bundle

Gene Ontology

Mouse over links to read term descriptions.
GO:0030131   clathrin adaptor complex  
GO:0005515   protein binding  
GO:0005488   binding  
GO:0003824   catalytic activity  
GO:0008641   small protein activating enzyme activity  
GO:0008152   metabolic process  
GO:0006886   intracellular protein transport  
GO:0006810   transport  
GO:0006464   protein modification process  
GO:0016192   vesicle-mediated transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 321 1w63 (M) 79 401 37.00 0 1 0.487353 1.42
1 287 2jkr (M) 77 367 69.00 0 1 0.844116 0.85
1 60 4p6z (S) 79 138 37.00 0.12 0.92 0.6076 -1.01
16 61 5mc7 (A) 105 150 17.00 0 0.15 0.194996 -0.1
93 198 3l81 (A) 185 285 34.00 0.000000084 1 0.471196 0
272 1081 5l6h (A) 18 722 37.00 0 1 0.828844 0.97
272 1085 6dc6 (A) 54 760 36.00 0 1 0.80953 0.9
273 431 1jw9 (B) 12 172 24.00 0 0.78 0.414144 -0.3
792 901 5ff5 (A) 120 231 17.00 0.000031 0.28 0.315882 -0.53

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128447)

Species Accession Gene Product
Arabidopsis thaliana AT5G46630   clathrin adaptor complexes medium subunit family protein
Brugia malayi Bm1_38960   Dumpy : shorter than wild-type protein 23
Candida albicans CaO19.2194   similar to S. cerevisiae APM4 (YOL062C) medium subunit of the clathrin-associated protein AP-2 complex
Candida albicans CaO19.9740   similar to S. cerevisiae APM4 (YOL062C) medium subunit of the clathrin-associated protein AP-2 complex
Caenorhabditis elegans CELE_R160.1   Protein DPY-23, isoform A
Dictyostelium discoideum DDB_G0277139   clathrin-adaptor medium chain AP-2
Drosophila melanogaster Dmel_CG7057   Adaptor Protein complex 2, mu subunit
Echinococcus granulosus EgrG_000440900   AP 2 complex subunit mu 1
Entamoeba histolytica EHI_135430   Clathrin coat assembly protein, putative
Entamoeba histolytica EHI_124560   AP-2 complex subunit mu, putative
Echinococcus multilocularis EmuJ_000440900   AP 2 complex subunit mu 1
Giardia lamblia GL50803_8917   Mu adaptin
Homo sapiens ENSG00000161203   adaptor-related protein complex 2, mu 1 subunit
Leishmania braziliensis LbrM.35.3250   clathrin coat assembly protein-like protein
Leishmania donovani LdBPK_363180.1   clathrin coat assembly protein-like protein
Leishmania infantum LinJ.36.3180   clathrin coat assembly protein-like protein
Leishmania major LmjF.36.3030   clathrin coat assembly protein-like protein
Leishmania mexicana LmxM.36.3030   clathrin coat assembly protein-like protein
Loa Loa (eye worm) LOAG_02601   shorter than wild-type protein 23
Mus musculus ENSMUSG00000022841   adaptor-related protein complex 2, mu 1 subunit
Neospora caninum NCLIV_031310   clathrin coat assembly protein AP50, putative
Oryza sativa 4330379   Os02g0690700
Saccharomyces cerevisiae YOL062C   Apm4p
Schistosoma japonicum Sjp_0041760   AP-2 complex subunit mu-1, putative
Schistosoma japonicum Sjp_0041720   Ubiquitin-like modifier-activating enzyme 6, putative
Schistosoma japonicum Sjp_0041730   AP-2 complex subunit mu-1, putative
Schistosoma japonicum Sjp_0088960   Ubiquitin-like modifier-activating enzyme 6, putative
Schistosoma japonicum Sjp_0306750   Ubiquitin-like modifier-activating enzyme 6, putative
Schistosoma japonicum Sjp_0105920   AP-2 complex subunit mu-1-B, putative
Schistosoma mansoni Smp_026540.2   clathrin coat associated protein ap-50
Schistosoma mansoni Smp_026540.1   clathrin coat associated protein ap-50
Schmidtea mediterranea mk4.003048.02   AP-2 complex subunit mu
Schmidtea mediterranea mk4.025010.01   Putative clathrin coat associated protein ap-50
Schmidtea mediterranea mk4.003048.01   Putative clathrin coat associated protein ap-50
Schmidtea mediterranea mk4.003048.03   AP-2 complex subunit mu
Schmidtea mediterranea mk4.026123.01  
Trypanosoma cruzi TcCLB.510105.30   clathrin coat assembly protein, putative
Trypanosoma cruzi TcCLB.509715.20   clathrin coat assembly protein, putative
Toxoplasma gondii TGME49_230920   adaptor complexes medium subunit family protein
Trichomonas vaginalis TVAG_453580   clathrin coat assembly protein, putative
Trichomonas vaginalis TVAG_226350   clathrin coat assembly protein ap-1, putative

Essentiality

Smp_026540.2 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_R160.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_R160.1 Caenorhabditis elegans larval arrest wormbase
CELE_R160.1 Caenorhabditis elegans larval lethal wormbase
CELE_R160.1 Caenorhabditis elegans slow growth wormbase
TGME49_230920 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0047 0.4524 0.1256
0.01 0.5175 0.6093
0.01 0.5175 0.6093
0.0083 0.2799 0.2637
0.01 0.5175 0.6093
0.0084 0.3805 0.3625

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_026540.2 (Schistosoma mansoni), clathrin coat associated protein ap-50
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