Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0097 | 0.0603 | 1 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0054 | 0 | 0.5 |
Leishmania major | tyrosine specific protein phosphatase, putative | 0.0054 | 0 | 0.5 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0097 | 0.0603 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0097 | 0.0603 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0332 | 0.3872 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0097 | 0.0603 | 0.1557 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0097 | 0.0603 | 1 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0054 | 0 | 0.5 |
Trichomonas vaginalis | pten, drome, putative | 0.0054 | 0 | 0.5 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0097 | 0.0603 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0097 | 0.0603 | 1 |
Entamoeba histolytica | Pten 3-phosphoinositide phosphatase, putative | 0.0054 | 0 | 0.5 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0054 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 0.8651 | 0.9207 |
Brugia malayi | Protein kinase domain containing protein | 0.0332 | 0.3872 | 0.3872 |
Onchocerca volvulus | 0.0718 | 0.9255 | 1 | |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0332 | 0.3872 | 0.4121 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0097 | 0.0603 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0097 | 0.0603 | 1 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0097 | 0.0603 | 0.0642 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0054 | 0 | 0.5 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0097 | 0.0603 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 0.8651 | 0.9207 |
Trypanosoma brucei | protein tyrosine phosphatase 1 | 0.0054 | 0 | 0.5 |
Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.0097 | 0.0603 | 0.1557 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0097 | 0.0603 | 0.1557 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0097 | 0.0603 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0728 | 0.9397 | 1 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0054 | 0 | 0.5 |
Leishmania major | protein-tyrosine phosphatase 1-like protein | 0.0054 | 0 | 0.5 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0097 | 0.0603 | 0.1557 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0097 | 0.0603 | 0.1557 |
Giardia lamblia | Protein tyrosine phosphatase | 0.0054 | 0 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.0097 | 0.0603 | 0.1557 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 0.8651 | 0.9207 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1.309 | Cytotoxicity against Homo sapiens (human) MCF7 cells | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.