Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | ubiquitin-activating enzyme e1, putative | 0.0114 | 0.0211 | 0.0744 |
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.0576 | 0.2831 | 1 |
Schistosoma mansoni | clathrin coat associated protein ap-50 | 0.0153 | 0.043 | 0.0261 |
Echinococcus multilocularis | ubiquitin modifier activating enzyme 1 | 0.0214 | 0.0778 | 0.0778 |
Echinococcus granulosus | ubiquitin modifier activating enzyme 1 | 0.0214 | 0.0778 | 0.0778 |
Toxoplasma gondii | hypothetical protein | 0.0118 | 0.0232 | 0.0227 |
Giardia lamblia | Ubiquitin-conjugating enzyme E1 | 0.0139 | 0.0352 | 0.5 |
Entamoeba histolytica | ThiF family protein | 0.0107 | 0.0173 | 0.0169 |
Trypanosoma brucei | ubiquitin-activating enzyme E1, putative | 0.0139 | 0.0352 | 0.0674 |
Trichomonas vaginalis | molybdopterin biosynthesis moeb protein, putative | 0.0576 | 0.2831 | 0.3981 |
Trypanosoma cruzi | ubiquitin-activating enzyme E1, putative | 0.0139 | 0.0352 | 0.0779 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0173 | 0.0169 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0107 | 0.0173 | 0.0237 |
Loa Loa (eye worm) | ube1-prov protein | 0.0214 | 0.0778 | 0.0773 |
Leishmania major | ubiquitin-activating enzyme e1, putative | 0.0139 | 0.0352 | 0.1244 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0107 | 0.0173 | 0.0237 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.1331 | 0.7105 | 1 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1c, putative | 0.0178 | 0.0572 | 0.0799 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0178 | 0.0572 | 0.0799 |
Trypanosoma brucei | NEDD8 activating enzyme subunit, putative | 0.0576 | 0.2831 | 1 |
Trypanosoma cruzi | NEDD8-activating enzyme E1 regulatory subunit, putative | 0.0107 | 0.0173 | 0.0113 |
Echinococcus granulosus | ubiquitin modifier activating enzyme 6 | 0.0214 | 0.0778 | 0.0778 |
Plasmodium falciparum | NEDD8-activating enzyme E1 catalytic subunit, putative | 0.0576 | 0.2831 | 1 |
Leishmania major | ubiquitin activating enzyme, putative | 0.0576 | 0.2831 | 1 |
Echinococcus granulosus | NEDD8 activating enzyme E1 regulatory subunit | 0.0107 | 0.0173 | 0.0173 |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.0214 | 0.0778 | 0.0773 |
Schistosoma mansoni | sumo-1-activating enzyme E1a | 0.0118 | 0.0232 | 0.0059 |
Schistosoma mansoni | clathrin coat associated protein ap-50 | 0.0153 | 0.043 | 0.0261 |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.1841 | 1 | 1 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0104 | 0.0156 | 0.0213 |
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.0576 | 0.2831 | 1 |
Toxoplasma gondii | NEDD8-activating enzyme E1 catalytic subunit | 0.1841 | 1 | 1 |
Echinococcus granulosus | NEDD8 activating enzyme E1 catalytic subunit | 0.1841 | 1 | 1 |
Loa Loa (eye worm) | ectopic membrane ruffles in embryo protein 1 | 0.1841 | 1 | 1 |
Plasmodium falciparum | SUMO-activating enzyme subunit 1 | 0.0118 | 0.0232 | 0.0803 |
Trypanosoma cruzi | ubiquitin-activating enzyme E1, putative | 0.0139 | 0.0352 | 0.0779 |
Entamoeba histolytica | ubiquitin-activating enzyme E1 1, putative | 0.0178 | 0.0572 | 0.0567 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0232 | 0.0227 |
Leishmania major | hypothetical protein, conserved | 0.0107 | 0.0173 | 0.0612 |
Brugia malayi | ThiF family protein | 0.0118 | 0.0232 | 0.0059 |
Echinococcus multilocularis | NEDD8 activating enzyme E1 catalytic subunit | 0.1841 | 1 | 1 |
Brugia malayi | ube1-prov protein | 0.0214 | 0.0778 | 0.0615 |
Plasmodium falciparum | ubiquitin-activating enzyme E1 | 0.0214 | 0.0778 | 0.2735 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0178 | 0.0572 | 0.0799 |
Echinococcus granulosus | SUMO activating enzyme subunit 1 | 0.0118 | 0.0232 | 0.0232 |
Trypanosoma brucei | ubiquitin-activating enzyme E1, putative | 0.0114 | 0.0211 | 0.0141 |
Echinococcus multilocularis | SUMO activating enzyme subunit 1 | 0.0118 | 0.0232 | 0.0232 |
Schistosoma mansoni | ubiquitin-activating enzyme E1C | 0.1841 | 1 | 1 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1 X, putative | 0.0109 | 0.0183 | 0.0251 |
Schistosoma mansoni | ubiquitin-activating enzyme E1 | 0.0183 | 0.06 | 0.0434 |
Plasmodium vivax | ubiquitin-activating enzyme E1C, putative | 0.0576 | 0.2831 | 1 |
Echinococcus multilocularis | NEDD8 activating enzyme E1 regulatory subunit | 0.0107 | 0.0173 | 0.0173 |
Echinococcus multilocularis | ubiquitin modifier activating enzyme 6 | 0.0214 | 0.0778 | 0.0778 |
Plasmodium vivax | ubiquitin activating enzyme, putative | 0.0118 | 0.0232 | 0.0803 |
Toxoplasma gondii | ThiF family protein | 0.0107 | 0.0173 | 0.0169 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.00016 uM/ml | Antimycobacterial activity against Mycobacterium tuberculosis | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.