Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0097 | 0.0603 | 0.1557 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0097 | 0.0603 | 0.1557 |
Leishmania major | protein-tyrosine phosphatase 1-like protein | 0.0054 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 0.8651 | 0.9207 |
Giardia lamblia | Protein tyrosine phosphatase | 0.0054 | 0 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.0097 | 0.0603 | 0.1557 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0054 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0728 | 0.9397 | 1 |
Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.0097 | 0.0603 | 0.1557 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0097 | 0.0603 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0097 | 0.0603 | 0.1557 |
Trypanosoma brucei | protein tyrosine phosphatase 1 | 0.0054 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 0.8651 | 0.9207 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0054 | 0 | 0.5 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0097 | 0.0603 | 1 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0097 | 0.0603 | 0.0642 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0097 | 0.0603 | 1 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0097 | 0.0603 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0332 | 0.3872 | 0.3872 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 0.8651 | 0.9207 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0332 | 0.3872 | 0.4121 |
Onchocerca volvulus | 0.0718 | 0.9255 | 1 | |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0054 | 0 | 0.5 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0097 | 0.0603 | 1 |
Entamoeba histolytica | Pten 3-phosphoinositide phosphatase, putative | 0.0054 | 0 | 0.5 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0097 | 0.0603 | 1 |
Trichomonas vaginalis | pten, drome, putative | 0.0054 | 0 | 0.5 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0097 | 0.0603 | 0.1557 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0332 | 0.3872 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0097 | 0.0603 | 1 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0054 | 0 | 0.5 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0097 | 0.0603 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0097 | 0.0603 | 1 |
Leishmania major | tyrosine specific protein phosphatase, putative | 0.0054 | 0 | 0.5 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0054 | 0 | 0.5 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0097 | 0.0603 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1.033 | Cytotoxicity against Homo sapiens (human) MCF7 cells | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.