Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable esterase LipL | 0.0039 | 0.0054 | 0.0903 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.0003 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.0054 | 0.0903 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.0054 | 0.5 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0003 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.002 | 0.3277 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0039 | 0.0054 | 0.0903 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0162 | 0.0375 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0039 | 0.0054 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0162 | 0.0375 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.002 | 0.3277 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0039 | 0.0054 | 0.0903 |
Loa Loa (eye worm) | hypothetical protein | 0.3856 | 1 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0162 | 0.0375 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.002 | 0.0017 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.002 | 0.3277 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.002 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.002 | 0.3277 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0039 | 0.0054 | 0.0903 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.002 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0054 | 0.0052 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.002 | 0.3277 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.0375 | 0.0372 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0054 | 0.0035 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0039 | 0.0054 | 0.0903 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0054 | 0.0052 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.002 | 0.3277 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0054 | 0.5 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.3856 | 1 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0054 | 0.0035 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.002 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.0054 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0054 | 0.0052 |
Mycobacterium leprae | Probable lipase LipE | 0.0039 | 0.0054 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0054 | 0.0052 |
Mycobacterium ulcerans | lipase LipD | 0.0039 | 0.0054 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0003 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0054 | 0.0052 |
Mycobacterium leprae | conserved hypothetical protein | 0.0039 | 0.0054 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0039 | 0.0054 | 0.0903 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.0375 | 0.0372 |
Onchocerca volvulus | 0.0039 | 0.0054 | 0.0035 | |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0054 | 0.0052 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.0054 | 0.0035 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0039 | 0.0054 | 0.0052 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0039 | 0.0054 | 1 |
Toxoplasma gondii | prostaglandin-E synthase | 0.3856 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.0054 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.0054 | 0.0035 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.002 | 0.3277 |
Trichomonas vaginalis | esterase, putative | 0.0039 | 0.0054 | 0.5 |
Brugia malayi | beta-lactamase | 0.0039 | 0.0054 | 0.0035 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0249 | 0.0602 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.0054 | 0.5 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.3856 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.002 | 0.0017 |
Trypanosoma brucei | Prostaglandin E synthase | 0.3856 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.002 | 0.0326 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.0054 | 0.5 |
Brugia malayi | Muscleblind-like protein | 0.0162 | 0.0375 | 0.0356 |
Onchocerca volvulus | 0.0039 | 0.0054 | 0.0035 | |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0039 | 0.0054 | 1 |
Onchocerca volvulus | 0.0039 | 0.0054 | 0.0035 | |
Mycobacterium ulcerans | hypothetical protein | 0.0039 | 0.0054 | 1 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.3856 | 1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0054 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0039 | 0.0054 | 0.0903 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0026 | 0.002 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.002 | 0.0326 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.002 | 0.3277 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.0054 | 0.0903 |
Onchocerca volvulus | 0.3856 | 1 | 1 | |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.0054 | 0.0903 |
Loa Loa (eye worm) | beta-lactamase | 0.0039 | 0.0054 | 0.0052 |
Plasmodium vivax | hypothetical protein, conserved | 0.0039 | 0.0054 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 0 % | Phytotoxicity against directly seeded Oryza sativa (rice) seedlings assessed as phytotoxic activity ratings (0- no effect to 5-complete killing rating scale) at 100 g/a measured after 3 weeks post compound treatment under green house conditions | ChEMBL. | 27393589 |
Activity (functional) | = 77 % | Relieving activity against bensulfuron-methyl induced injury to Oryza sativa (rice) assessed as growth rate at 1 uM (Rbv = 46 to 53%) | ChEMBL. | 27393060 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.