Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Nicotiana tabacum | Acetolactate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0043 | 0.1606 | 0.5 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0076 | 0.3619 | 0.3582 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0019 | 0.0176 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0414 | 0.0586 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0133 | 0.7054 | 1 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0133 | 0.7054 | 1 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0133 | 0.7054 | 1 |
Brugia malayi | Thiamine pyrophosphate enzyme, central domain containing protein | 0.0133 | 0.7054 | 0.6927 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0133 | 0.7054 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2769 | 0.3357 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0414 | 0.0509 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0414 | 0.0358 |
Schistosoma mansoni | acetolactate synthase | 0.0114 | 0.5883 | 1 |
Mycobacterium ulcerans | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | 0.0024 | 0.0435 | 0.054 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0019 | 0.0176 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0414 | 0.0358 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0076 | 0.3611 | 0.5079 |
Giardia lamblia | Pyruvate-flavodoxin oxidoreductase | 0.0019 | 0.0176 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0076 | 0.3611 | 0.5079 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.2769 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase (beta subunit) | 0.0019 | 0.0176 | 0.0249 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0043 | 0.1606 | 0.5 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND : 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE (SH | 0.0024 | 0.0435 | 0.0033 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.1606 | 0.2214 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2769 | 0.3357 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 1 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0058 | 0.0082 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.2769 | 0.2728 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2769 | 0.3357 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0019 | 0.0176 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1196 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0414 | 0.0509 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0133 | 0.7054 | 1 |
Treponema pallidum | pyruvate oxidoreductase | 0.0019 | 0.0176 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1196 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0414 | 0.0509 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0414 | 0.0509 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0181 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0414 | 0.0358 |
Leishmania major | phosphonopyruvate decarboxylase-like protein | 0.0043 | 0.1606 | 0.373 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2769 | 0.3357 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0093 | 0.4664 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0114 | 0.5883 | 1 |
Mycobacterium ulcerans | acetolactate synthase | 0.0076 | 0.3611 | 0.5079 |
Mycobacterium ulcerans | 2-oxoglutarate ferredoxin oxidoreductase subunit beta | 0.0019 | 0.0176 | 0.0169 |
Brugia malayi | RNA binding protein | 0.0062 | 0.2769 | 0.2457 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0414 | 0.2334 |
Brugia malayi | hypothetical protein | 0.0036 | 0.1196 | 0.0816 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1196 | 1 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0133 | 0.7054 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.2769 | 0.2457 |
Mycobacterium ulcerans | hypothetical protein | 0.0133 | 0.7054 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.2769 | 0.2728 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0019 | 0.0176 | 0.5 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0019 | 0.0176 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0414 | 0.0509 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0414 | 0.0586 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0414 | 0.0509 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0076 | 0.3611 | 1 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0043 | 0.1606 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0414 | 0.2334 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.2769 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0043 | 0.1606 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.2769 | 0.2457 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0414 | 0.2334 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0019 | 0.0176 | 0.5 |
Loa Loa (eye worm) | ILVBL protein | 0.008 | 0.3879 | 0.3843 |
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.0057 | 0.2448 | 0.347 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0093 | 0.4664 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2769 | 0.3357 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1196 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0414 | 0.0509 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0058 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.2769 | 0.2728 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0414 | 0.0509 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 19.2 nM | Inhibition of wild type Nicotiana tabacum (tobacco) GST-tagged acetolactate synthase expressed in Escherichia coli by modified Westerfeld method | ChEMBL. | 10329466 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.