Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Zea mays | Protoporphyrinogen IX oxidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | protoporphyrinogen oxidase | Protoporphyrinogen IX oxidase | 535 aa | 458 aa | 23.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0192 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.004 | 0.0136 | 0.0223 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0136 | 0.0136 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0136 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0132 | 0.6123 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0132 | 0.6123 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.1132 | 0.1849 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0136 | 0.0136 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0136 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.1132 | 0.1849 |
Echinococcus granulosus | geminin | 0.0188 | 0.9717 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.9717 | 0.9717 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1132 | 0.1849 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0136 | 0.5 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0167 | 0.8362 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0132 | 0.6123 | 1 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0167 | 0.8362 | 0.8586 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.1132 | 0.1849 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.9717 | 0.9717 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0136 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0192 | 1 | 0.5 |
Echinococcus multilocularis | geminin | 0.0188 | 0.9717 | 0.9713 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0192 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 5.41 | Inhibition of protoporphyrinogen oxidase in Zea mays (maize) seedlings leaves etioplasts using protoporphyrinogen IX incubated for 30 min by fluorescence spectroscopy | ChEMBL. | 18808144 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.