Detailed information for compound 184299

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 218.082 | Formula: C4H12O6P2
  • H donors: 4 H acceptors: 6 LogP: -2.01 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(P(=O)(O)O)P(=O)(O)O
  • InChi: 1S/C4H12O6P2/c1-2-3-4(11(5,6)7)12(8,9)10/h4H,2-3H2,1H3,(H2,5,6,7)(H2,8,9,10)
  • InChiKey: OWWOMIFQTFZNGK-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens farnesyl diphosphate synthase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Cryptosporidium hominis farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) Get druggable targets OG5_127590 All targets in OG5_127590
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma brucei gambiense farnesyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Leishmania infantum farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma congolense farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma brucei farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Theileria parva farnesyl pyrophosphate synthetase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Brugia malayi Polyprenyl synthetase family protein Get druggable targets OG5_127590 All targets in OG5_127590
Candida albicans similar to S. cerevisiae ERG20 (YJL167W) farnesyl diphosphate synthetase (FPP synthetase) Get druggable targets OG5_127590 All targets in OG5_127590
Leishmania mexicana farnesyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Schistosoma mansoni farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Babesia bovis farnesyl pyrophosphate synthetase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Plasmodium knowlesi geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Plasmodium yoelii farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Plasmodium vivax geranylgeranyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma cruzi farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Giardia lamblia Farnesyl diphosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Schistosoma japonicum ko:K00787 dimethylallyltranstransferase [EC2.5.1.1], putative Get druggable targets OG5_127590 All targets in OG5_127590
Echinococcus multilocularis farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Toxoplasma gondii polyprenyl synthetase superfamily protein Get druggable targets OG5_127590 All targets in OG5_127590
Plasmodium berghei geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Echinococcus granulosus farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Loa Loa (eye worm) polyprenyl synthetase Get druggable targets OG5_127590 All targets in OG5_127590
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Candida albicans similar to S. cerevisiae ERG20 (YJL167W) farnesyl diphosphate synthetase (FPP synthetase) Get druggable targets OG5_127590 All targets in OG5_127590
Leishmania major farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Leishmania donovani farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Neospora caninum hypothetical protein Get druggable targets OG5_127590 All targets in OG5_127590
Cryptosporidium parvum putative farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus NCK adaptor protein 0.0366 0.3329 0.3329
Loa Loa (eye worm) hypothetical protein 0.0366 0.3329 0.3329
Echinococcus multilocularis tyrosine protein kinase Fyn 0.061 1 1
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0244 0 0.5
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.061 1 1
Echinococcus granulosus N chimaerin 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Trichomonas vaginalis protein tyrosine kinase, putative 0.0244 0 0.5
Brugia malayi SH2 domain containing protein 0.0366 0.3329 0.3329
Brugia malayi Protein kinase domain containing protein 0.061 1 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.061 1 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0366 0.3329 0.3329
Loa Loa (eye worm) SH2 domain-containing protein 0.0366 0.3329 0.3329
Brugia malayi Variant SH3 domain containing protein 0.0366 0.3329 0.3329
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0366 0.3329 0.3329
Brugia malayi Protein kinase domain containing protein 0.061 1 1
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0244 0 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0366 0.3329 0.3329
Trichomonas vaginalis conserved hypothetical protein 0.0244 0 0.5
Echinococcus granulosus SH2 domain containing protein 7 0.0366 0.3329 0.3329
Trichomonas vaginalis conserved hypothetical protein 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Brugia malayi Sex muscle abnormal protein 5 0.0366 0.3329 0.3329
Giardia lamblia Protein 21.1 0.0244 0 0.5
Plasmodium falciparum protein kinase, putative 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Giardia lamblia Kinase 0.0244 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0244 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0366 0.3329 0.3329
Echinococcus multilocularis N chimaerin 0.0366 0.3329 0.3329
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0366 0.3329 0.3329
Echinococcus granulosus growth factor receptor bound protein 2 0.0366 0.3329 0.3329
Schistosoma mansoni tyrosine kinase 0.061 1 1
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Trypanosoma brucei Flagellum attachment zone protein 20 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Onchocerca volvulus 0.061 1 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0244 0 0.5
Onchocerca volvulus 0.061 1 1
Brugia malayi SH2 domain containing protein 0.0366 0.3329 0.3329
Plasmodium falciparum protein kinase, putative 0.0244 0 0.5
Brugia malayi SH2 domain containing protein 0.0366 0.3329 0.3329
Echinococcus granulosus tyrosine protein kinase Btk29A 0.061 1 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.061 1 1
Trichomonas vaginalis STE family protein kinase 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.061 1 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.061 1 1
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.061 1 1
Loa Loa (eye worm) hypothetical protein 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Onchocerca volvulus 0.061 1 1
Echinococcus granulosus suppressor of cytokine signaling 7 0.0366 0.3329 0.3329
Toxoplasma gondii protein kinase 0.0244 0 0.5
Echinococcus granulosus tyrosine protein kinase Blk 0.061 1 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Giardia lamblia Kinase, NEK 0.0244 0 0.5
Schistosoma mansoni suppressor of cytokine signaling 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Brugia malayi STAT protein, DNA binding domain containing protein 0.0366 0.3329 0.3329
Brugia malayi Variant SH3 domain containing protein 0.0366 0.3329 0.3329
Entamoeba histolytica protein kinase, putative 0.0366 0.3329 0.3329
Schistosoma mansoni tyrosine kinase 0.061 1 1
Loa Loa (eye worm) SRC-1 0.061 1 1
Brugia malayi cytokine inducible SH2-containing protein 5 0.0366 0.3329 0.3329
Echinococcus granulosus SH2 domain containing adapter protein F 0.0366 0.3329 0.3329
Brugia malayi tRNA modification GTPase TrmE family protein 0.0366 0.3329 0.3329
Trichomonas vaginalis AGC family protein kinase 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Brugia malayi hypothetical protein 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Brugia malayi SH2 domain containing protein 0.061 1 1
Schistosoma mansoni growth factor receptor-bound protein 0.0366 0.3329 0.3329
Onchocerca volvulus 0.061 1 1
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0366 0.3329 0.3329
Loa Loa (eye worm) hypothetical protein 0.0366 0.3329 0.3329
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0244 0 0.5
Schistosoma mansoni tensin 0.0366 0.3329 0.3329
Loa Loa (eye worm) hypothetical protein 0.0366 0.3329 0.3329
Schistosoma mansoni vav2 0.0366 0.3329 0.3329
Brugia malayi SRC-1 0.061 1 1
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0366 0.3329 0.3329
Echinococcus multilocularis tyrosine protein kinase Src42A 0.061 1 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.061 1 1
Echinococcus granulosus tyrosine protein kinase Srms 0.061 1 1
Loa Loa (eye worm) hypothetical protein 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Loa Loa (eye worm) hypothetical protein 0.061 1 1
Loa Loa (eye worm) TK protein kinase 0.061 1 1
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Echinococcus multilocularis tensin 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Echinococcus granulosus suppressor of cytokine signaling 6 0.0366 0.3329 0.3329
Toxoplasma gondii STE kinase 0.0244 0 0.5
Schistosoma mansoni hypothetical protein 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.061 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.061 1 1
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0366 0.3329 0.3329
Plasmodium vivax tyrosine kinase-like protein, putative 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Schistosoma mansoni tyrosine kinase 0.061 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0366 0.3329 0.3329
Echinococcus granulosus tyrosine protein kinase Fyn 0.061 1 1
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Schistosoma mansoni tyrosine kinase 0.061 1 1
Echinococcus multilocularis SHC transforming protein 3 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Trypanosoma cruzi protein kinase, putative 0.0244 0 0.5
Echinococcus granulosus SHC transforming protein 3 0.0366 0.3329 0.3329
Brugia malayi SH2 domain containing protein 0.0366 0.3329 0.3329
Echinococcus granulosus tyrosine protein kinase Fps85D 0.061 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0244 0 0.5
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0366 0.3329 0.3329
Echinococcus multilocularis SH2 motif 0.0366 0.3329 0.3329
Loa Loa (eye worm) TK/FER protein kinase 0.061 1 1
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0366 0.3329 0.3329
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.061 1 1
Plasmodium falciparum protein kinase, putative 0.0244 0 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.061 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0244 0 0.5
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0366 0.3329 0.3329
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0366 0.3329 0.3329
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Echinococcus granulosus tensin 0.0366 0.3329 0.3329
Trypanosoma brucei Pseudokinase, putative 0.0244 0 0.5
Trypanosoma brucei protein kinase, putative 0.0244 0 0.5
Brugia malayi RhoGAP domain containing protein 0.0366 0.3329 0.3329
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.061 1 1
Echinococcus granulosus hypothetical protein 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Trypanosoma cruzi protein kinase, putative 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Onchocerca volvulus 0.061 1 1
Brugia malayi SH2 domain containing protein 0.0366 0.3329 0.3329
Trichomonas vaginalis protein kinase atn1, putative 0.0244 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0366 0.3329 0.3329
Schistosoma mansoni tyrosine kinase 0.061 1 1
Schistosoma mansoni tyrosine kinase 0.061 1 1
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0366 0.3329 0.3329
Brugia malayi Tyrosine-protein kinase abl-1 0.061 1 1
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Schistosoma mansoni tensin-related 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Brugia malayi Variant SH3 domain containing protein 0.0366 0.3329 0.3329
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0244 0 0.5
Plasmodium falciparum tyrosine kinase-like protein 0.0244 0 0.5
Echinococcus granulosus tyrosine protein kinase Src64B 0.061 1 1
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Echinococcus multilocularis tyrosine protein kinase shark 0.061 1 1
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0244 0 0.5
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0366 0.3329 0.3329
Onchocerca volvulus 0.0366 0.3329 0.3329
Plasmodium vivax tyrosine kinase-like protein, putative 0.0244 0 0.5
Plasmodium vivax protein kinase, putative 0.0244 0 0.5
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0244 0 0.5
Echinococcus multilocularis tyrosine protein kinase Fgr 0.061 1 1
Loa Loa (eye worm) hypothetical protein 0.0366 0.3329 0.3329
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0366 0.3329 0.3329
Echinococcus multilocularis tyrosine protein kinase ABL1 0.061 1 1
Giardia lamblia Kinase, NEK 0.0244 0 0.5
Leishmania major protein kinase, putative 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.061 1 1
Loa Loa (eye worm) hypothetical protein 0.0366 0.3329 0.3329
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.061 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.061 1 1
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.061 1 1
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0366 0.3329 0.3329
Loa Loa (eye worm) hypothetical protein 0.0366 0.3329 0.3329
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0366 0.3329 0.3329
Echinococcus granulosus c src tyrosine kinase 0.061 1 1
Echinococcus granulosus signal transduction protein lnk realted 0.0366 0.3329 0.3329
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0366 0.3329 0.3329
Plasmodium falciparum tyrosine kinase-like protein 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Loa Loa (eye worm) TK/ABL protein kinase 0.061 1 1
Brugia malayi Variant SH3 domain containing protein 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.061 1 1
Leishmania major hypothetical protein, conserved 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Entamoeba histolytica SH2-protein kinase domain containing protein 0.061 1 1
Schistosoma mansoni growth factor receptor-bound protein 0.0366 0.3329 0.3329
Onchocerca volvulus 0.0366 0.3329 0.3329
Loa Loa (eye worm) SH2 domain-containing protein 0.0366 0.3329 0.3329
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.061 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.061 1 1
Echinococcus granulosus SH2 motif 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Schistosoma mansoni hypothetical protein 0.0366 0.3329 0.3329
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0366 0.3329 0.3329
Echinococcus multilocularis growth factor receptor bound protein 2 0.0366 0.3329 0.3329
Echinococcus granulosus tyrosine protein kinase shark 0.061 1 1
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.061 1 1
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Schistosoma mansoni shc transforming protein 0.0366 0.3329 0.3329
Leishmania major protein kinase, putative 0.0244 0 0.5
Schistosoma mansoni suppressor of cytokine signaling 0.0366 0.3329 0.3329
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0366 0.3329 0.3329
Schistosoma mansoni tensin-related 0.0366 0.3329 0.3329
Echinococcus multilocularis tyrosine protein kinase Abl 0.061 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.061 1 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0244 0 0.5
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Echinococcus granulosus SH2 motif 0.0366 0.3329 0.3329
Onchocerca volvulus 0.0366 0.3329 0.3329
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Echinococcus multilocularis tyrosine protein kinase Blk 0.061 1 1
Echinococcus multilocularis SH2 motif 0.0366 0.3329 0.3329
Echinococcus multilocularis 0.0366 0.3329 0.3329
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Echinococcus multilocularis tensin 0.0366 0.3329 0.3329
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Brugia malayi protein-tyrosine kinase 0.061 1 1
Schistosoma mansoni adapter molecule crk 0.0366 0.3329 0.3329
Trichomonas vaginalis TK family protein kinase 0.0244 0 0.5
Brugia malayi Protein kinase domain containing protein 0.061 1 1
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Schistosoma mansoni GTPase activating protein 0.0366 0.3329 0.3329
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.061 1 1
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.061 1 1
Echinococcus granulosus expressed conserved protein 0.0366 0.3329 0.3329
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0366 0.3329 0.3329
Loa Loa (eye worm) STAT protein 0.0366 0.3329 0.3329
Onchocerca volvulus 0.061 1 1
Onchocerca volvulus 0.0366 0.3329 0.3329
Echinococcus multilocularis signal transduction protein lnk realted 0.0366 0.3329 0.3329
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Schistosoma mansoni tensin 0.0366 0.3329 0.3329
Schistosoma mansoni nck2/grb4 0.0366 0.3329 0.3329
Loa Loa (eye worm) hypothetical protein 0.0366 0.3329 0.3329
Echinococcus multilocularis c src tyrosine kinase 0.061 1 1
Echinococcus multilocularis SH2 motif 0.0366 0.3329 0.3329
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0366 0.3329 0.3329
Echinococcus granulosus tyrosine kinase 0.061 1 1
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Brugia malayi hypothetical protein 0.061 1 1
Brugia malayi Tensin 0.0366 0.3329 0.3329
Onchocerca volvulus 0.0366 0.3329 0.3329
Brugia malayi SH2 domain containing protein 0.061 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0244 0 0.5
Schistosoma mansoni tensin 0.0366 0.3329 0.3329
Schistosoma mansoni SH2A 0.0366 0.3329 0.3329
Echinococcus granulosus tyrosine kinase 0.061 1 1
Loa Loa (eye worm) hypothetical protein 0.0366 0.3329 0.3329
Echinococcus granulosus tyrosine protein kinase Src42A 0.0366 0.3329 0.3329
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0366 0.3329 0.3329
Echinococcus granulosus tyrosine protein kinase ABL1 0.061 1 1
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0366 0.3329 0.3329
Toxoplasma gondii protein kinase domain-containing protein 0.0244 0 0.5
Entamoeba histolytica SH2 domain containing protein 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Echinococcus multilocularis SH2 domain containing protein 7 0.0366 0.3329 0.3329
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.061 1 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0366 0.3329 0.3329
Brugia malayi SH2 domain containing protein 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Schistosoma mansoni signal transduction protein lnk-related 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Echinococcus multilocularis tyrosine protein kinase Srms 0.061 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.061 1 1
Echinococcus multilocularis NCK adaptor protein 0.0366 0.3329 0.3329
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0366 0.3329 0.3329
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0366 0.3329 0.3329
Brugia malayi SH2 domain containing protein 0.0366 0.3329 0.3329
Trichomonas vaginalis TKL family protein kinase 0.0244 0 0.5
Brugia malayi Protein kinase domain containing protein 0.061 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.061 1 1
Echinococcus multilocularis tyrosine kinase 0.061 1 1
Onchocerca volvulus 0.0366 0.3329 0.3329

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 90 uM Inhibitory concentration against Trypanosoma cruzi (amastigotes) ChEMBL. 12951099
IC50 (functional) > 90 uM Inhibitory concentration against Trypanosoma cruzi (amastigotes) ChEMBL. 12951099
IC50 (functional) > 100 uM Inhibitory concentration against Trypanosoma cruzi (epimastigotes) ChEMBL. 12951099
IC50 (functional) > 100 uM Inhibitory concentration against Trypanosoma cruzi (epimastigotes) ChEMBL. 12951099
IC50 (binding) = 150.36 uM Inhibition of Trypanosoma cruzi farnesyl pyrophosphate synthase ChEMBL. 12951099
IC50 (binding) = 150.36 uM Inhibition of Trypanosoma cruzi farnesyl pyrophosphate synthase ChEMBL. 12951099
Inhibition (functional) = 28 % Maximum inhibitory activity of the compound against Trypanosoma cruzi (amastigotes) ChEMBL. 12951099
Inhibition (functional) = 28 % Maximum inhibitory activity of the compound against Trypanosoma cruzi (amastigotes) ChEMBL. 12951099
Ki (binding) = 16.99 uM Binding affinity of the compound towards T. cruzi farnesyl pyrophosphate synthase (TcFPPS) ChEMBL. 12951099
Ki (binding) = 16.99 uM Binding affinity of the compound towards T. cruzi farnesyl pyrophosphate synthase (TcFPPS) ChEMBL. 12951099

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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