TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 424.44 | Formula: C24H22F2N2O3
H donors: 1 H acceptors: 1 LogP: 4.65 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CN(CCOc1ccc2c(c1)COc1c(C2=O)ccc(c1)Nc1ccc(cc1F)F)C
InChi: 1S/C24H22F2N2O3/c1-28(2)9-10-30-18-5-7-19-15(11-18)14-31-23-13-17(4-6-20(23)24(19)29)27-22-8-3-16(25)12-21(22)26/h3-8,11-13,27H,9-10,14H2,1-2H3
InChiKey: SMVYKQCSLCHIDB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 14	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania mexicana	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei gambiense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania braziliensis	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania infantum	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma congolense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Brugia malayi	P38 map kinase family protein 2	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma japonicum	ko:K04441 p38 MAP kinase, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania donovani	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 14	360 aa	336 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus multilocularis	activin receptor type	0.0477	0.858	1
Loa Loa (eye worm)	hypothetical protein	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Giardia lamblia	Kinase, NEK	0.0477	0.8566	0.5
Trypanosoma brucei	protein kinase, putative	0.0477	0.858	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0477	0.8566	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0477	0.8566	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0477	0.858	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0477	0.8566	1
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus multilocularis	integrin linked protein kinase	0.0477	0.8566	0.9983
Echinococcus multilocularis	protein kinase	0.0477	0.8566	0.9983
Loa Loa (eye worm)	TK/FAK protein kinase	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0477	0.8566	0.5
Echinococcus granulosus	tyrosine kinase	0.0477	0.8566	0.9983
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0477	0.8566	0.9983
Entamoeba histolytica	protein kinase domain containing protein	0.0477	0.858	0.0102
Brugia malayi	protein-tyrosine kinase	0.0477	0.8566	1
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0477	0.8566	0.9983
Loa Loa (eye worm)	TK/FER protein kinase	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus granulosus	tyrosine protein kinase pr2	0.0477	0.8566	0.9983
Loa Loa (eye worm)	hypothetical protein	0.0477	0.8566	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0477	0.8566	0.9983
Onchocerca volvulus		0.0477	0.8566	0.5
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0477	0.8566	0.9983
Loa Loa (eye worm)	TK/FER protein kinase	0.0477	0.8566	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0477	0.8566	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0477	0.8566	0.5
Entamoeba histolytica	hypothetical protein	0.0531	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Loa Loa (eye worm)	hypothetical protein	0.0477	0.8566	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0477	0.8566	0.9983
Plasmodium vivax	protein kinase, putative	0.0477	0.8566	0.5
Loa Loa (eye worm)	TK/ALK protein kinase	0.0477	0.8566	1
Loa Loa (eye worm)	TK protein kinase	0.0477	0.8566	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0477	0.8566	1
Giardia lamblia	Protein 21.1	0.0477	0.8566	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.0477	0.8566	0.9983
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0477	0.8566	0.9983
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0477	0.8566	0.5
Loa Loa (eye worm)	hypothetical protein	0.0477	0.8566	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0477	0.8566	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0477	0.8566	0.9983
Loa Loa (eye worm)	TK/EPH protein kinase	0.0477	0.8566	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0477	0.8566	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0477	0.8566	0.5
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Brugia malayi	Tyrosine-protein kinase PR2	0.0477	0.8566	1
Echinococcus multilocularis	protein tyrosine kinase	0.0477	0.8566	0.9983
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0477	0.8566	0.5
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Echinococcus granulosus	tyrosine kinase	0.0477	0.8566	0.9983
Echinococcus granulosus	tyrosine protein kinase	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0477	0.8566	0.9983
Brugia malayi	Furin-like cysteine rich region family protein	0.0477	0.8566	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0477	0.8566	1
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0477	0.8566	0.9983
Loa Loa (eye worm)	hypothetical protein	0.0477	0.8566	1
Loa Loa (eye worm)	SRC-1	0.0477	0.8566	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0477	0.8566	1
Leishmania major	hypothetical protein, conserved	0.0477	0.8566	0.9983
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0477	0.8566	0.5
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0477	0.8566	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0477	0.8566	1
Trypanosoma cruzi	protein kinase, putative	0.0477	0.8566	0.9983
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Onchocerca volvulus		0.0477	0.8566	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0477	0.8566	1
Trichomonas vaginalis	conserved hypothetical protein	0.0477	0.8566	0.5
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0477	0.8566	1
Echinococcus multilocularis	transfer RNA-Thr	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus granulosus	protein kinase	0.0477	0.8566	0.9983
Plasmodium falciparum	protein kinase, putative	0.0477	0.858	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Onchocerca volvulus	Tyrosine kinase homolog	0.0477	0.8566	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0477	0.8566	0.9983
Brugia malayi	Receptor family ligand binding region containing protein	0.0477	0.8566	1
Echinococcus multilocularis	tyrosine kinase	0.0477	0.8566	0.9983
Trichomonas vaginalis	CAMK family protein kinase	0.0477	0.8566	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0477	0.8566	0.9983
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0477	0.858	1
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Loa Loa (eye worm)	TK protein kinase	0.0477	0.8566	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0477	0.8566	0.9983
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0477	0.8566	0.9983
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0477	0.8566	1
Onchocerca volvulus		0.0477	0.8566	0.5
Loa Loa (eye worm)	TK protein kinase	0.0477	0.8566	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0477	0.8566	0.9983
Brugia malayi	Raf kinase	0.0477	0.8566	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0477	0.8566	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0477	0.8566	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0477	0.858	1
Schistosoma mansoni	protein kinase	0.0477	0.858	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0477	0.8566	0.9983
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0477	0.8566	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0477	0.8566	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0477	0.8566	1
Onchocerca volvulus		0.0477	0.8566	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0477	0.8566	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0477	0.8566	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0477	0.8566	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus granulosus	tyrosine kinase	0.0477	0.8566	0.9983
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Onchocerca volvulus		0.0477	0.8566	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Leishmania major	protein kinase, putative	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Onchocerca volvulus		0.0477	0.8566	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0477	0.8566	0.9983
Echinococcus multilocularis	tyrosine protein kinase csk	0.0477	0.8566	0.9983
Trichomonas vaginalis	conserved hypothetical protein	0.0477	0.8566	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0477	0.8566	0.9983
Giardia lamblia	Kinase, NEK	0.0477	0.8566	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0477	0.8566	0.9983
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0477	0.8566	0.5
Echinococcus multilocularis	insulin receptor	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0477	0.8566	0.9983
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0477	0.8566	1
Echinococcus granulosus	integrin linked protein kinase	0.0477	0.8566	0.9983
Onchocerca volvulus		0.0477	0.8566	0.5
Echinococcus multilocularis	FL cytokine receptor	0.0477	0.8566	0.9983
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Loa Loa (eye worm)	hypothetical protein	0.0477	0.8566	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0477	0.8566	0.9983
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0477	0.8566	0.9983
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Loa Loa (eye worm)	hypothetical protein	0.0477	0.8566	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0477	0.8566	0.9983
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0477	0.8566	0.9983
Echinococcus granulosus	insulin receptor	0.0477	0.8566	0.9983
Loa Loa (eye worm)	hypothetical protein	0.0477	0.8566	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0477	0.8566	0.9983
Echinococcus granulosus	epidermal growth factor receptor	0.0477	0.8566	0.9983
Onchocerca volvulus		0.0477	0.8566	0.5
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0477	0.8566	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Brugia malayi	ephrin receptor 1 precursor	0.0477	0.8566	1
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0477	0.8566	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0477	0.8566	0.9983
Loa Loa (eye worm)	hypothetical protein	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0477	0.8566	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0477	0.8566	0.9983
Echinococcus granulosus	protein tyrosine kinase	0.0477	0.8566	0.9983
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0477	0.8566	0.9983
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Trichomonas vaginalis	conserved hypothetical protein	0.0477	0.8566	0.5
Brugia malayi	SH2 domain containing protein	0.0477	0.8566	1
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0477	0.8566	1
Brugia malayi	SH2 domain containing protein	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus granulosus	tyrosine protein kinase shark	0.0477	0.8566	0.9983
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0477	0.8566	0.9983
Loa Loa (eye worm)	TK/ACK protein kinase	0.0477	0.8566	1
Loa Loa (eye worm)	TK protein kinase	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Onchocerca volvulus		0.0477	0.8566	0.5
Loa Loa (eye worm)	TK protein kinase	0.0477	0.8566	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0477	0.8566	0.9983
Onchocerca volvulus		0.0477	0.8566	0.5
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0477	0.8566	0.9983
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0477	0.8566	1
Loa Loa (eye worm)	hypothetical protein	0.0477	0.8566	1
Entamoeba histolytica	hypothetical protein	0.0531	1	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0477	0.8566	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0477	0.8566	0.9983
Trichomonas vaginalis	STE family protein kinase	0.0477	0.8566	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0477	0.8566	0.9983
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0477	0.8566	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0477	0.8566	0.9983
Echinococcus multilocularis	epidermal growth factor receptor	0.0477	0.8566	0.9983
Leishmania major	protein kinase, putative	0.0477	0.858	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0477	0.8566	0.9983
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0477	0.8566	0.9983
Trichomonas vaginalis	TK family protein kinase	0.0477	0.8566	0.5
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Schistosoma mansoni	protein kinase	0.0477	0.858	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0477	0.858	1
Onchocerca volvulus		0.0477	0.8566	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.0477	0.8566	0.9983
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Loa Loa (eye worm)	TK protein kinase	0.0477	0.8566	1
Loa Loa (eye worm)	hypothetical protein	0.0477	0.8566	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0477	0.8566	1
Echinococcus multilocularis	tyrosine kinase	0.0477	0.8566	0.9983
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0477	0.8566	0.9983
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0477	0.8566	0.9983
Loa Loa (eye worm)	TK/DDR protein kinase	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0477	0.8566	0.9983
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0477	0.8566	0.9983
Loa Loa (eye worm)	TK/RYK protein kinase	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Brugia malayi	hypothetical protein	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Onchocerca volvulus		0.0477	0.8566	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0477	0.8566	0.9983
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0477	0.8566	0.9983
Giardia lamblia	Kinase	0.0477	0.8566	0.5
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0477	0.8566	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0477	0.8566	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0477	0.8566	0.9983
Loa Loa (eye worm)	TK protein kinase	0.0477	0.8566	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0477	0.8566	0.9983
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0477	0.8566	0.9983
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0477	0.8566	0.9983
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0477	0.858	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0477	0.8566	0.9983
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0477	0.8566	0.9983
Loa Loa (eye worm)	TK/FER protein kinase	0.0477	0.8566	1
Trypanosoma cruzi	protein kinase, putative	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0477	0.8566	1
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0477	0.8566	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0477	0.858	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0477	0.8566	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0477	0.8566	0.9983
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0477	0.8566	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0477	0.8566	0.9983
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0477	0.8566	0.9983
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0477	0.8566	0.5
Loa Loa (eye worm)	hypothetical protein	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0477	0.8566	0.9983
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0477	0.8566	0.9983
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Echinococcus granulosus	activin receptor type	0.0477	0.858	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0477	0.8566	0.9983
Loa Loa (eye worm)	TK/FER protein kinase	0.0477	0.8566	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0477	0.8566	0.9983
Echinococcus multilocularis	tyrosine protein kinase csk	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Brugia malayi	SRC-1	0.0477	0.8566	1
Echinococcus granulosus	c src tyrosine kinase	0.0477	0.8566	0.9983
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Onchocerca volvulus		0.0477	0.8566	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0477	0.8566	1
Loa Loa (eye worm)	TK protein kinase	0.0477	0.8566	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0477	0.8566	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0477	0.8566	0.9983
Onchocerca volvulus		0.0477	0.8566	0.5
Echinococcus multilocularis	tyrosine protein kinase	0.0477	0.8566	0.9983
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus multilocularis	activated cdc42 kinase 1	0.0477	0.8566	0.9983
Echinococcus granulosus	activated cdc42 kinase 1	0.0477	0.8566	0.9983
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Brugia malayi	hypothetical protein	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0477	0.8566	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0531	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0477	0.8566	0.9983
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0477	0.8566	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.0477	0.8566	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.0477	0.8566	0.9983
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0477	0.8566	0.9983
Loa Loa (eye worm)	TK protein kinase	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0477	0.8566	0.9983
Loa Loa (eye worm)	TK protein kinase	0.0477	0.8566	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0477	0.858	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0477	0.8566	0.9983
Echinococcus multilocularis	heat shock protein 70	0.0477	0.8566	0.9983
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus multilocularis	protein kinase	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Onchocerca volvulus		0.0477	0.8566	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus granulosus	kinase suppressor of Ras 1	0.0477	0.8566	0.9983
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0477	0.8566	0.9983
Loa Loa (eye worm)	TK/FER protein kinase	0.0477	0.8566	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0477	0.8566	0.9983
Loa Loa (eye worm)	hypothetical protein	0.0477	0.8566	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0477	0.8566	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0477	0.8566	0.9983
Brugia malayi	hypothetical protein	0.0477	0.8566	1
Echinococcus granulosus	epidermal growth factor receptor	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Brugia malayi	integrin-linked kinase	0.0477	0.8566	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0477	0.8566	0.9983
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.0477	0.8566	0.9983
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0477	0.8566	1
Trichomonas vaginalis	AGC family protein kinase	0.0477	0.8566	0.5
Brugia malayi	Protein kinase domain containing protein	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Schistosoma mansoni	protein kinase	0.0477	0.858	1
Entamoeba histolytica	protein kinase, putative	0.0531	1	1
Brugia malayi	Guanylyl cyclase protein 23	0.0477	0.8566	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0477	0.8566	0.9983
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0477	0.8566	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0477	0.8566	0.9983
Brugia malayi	C-terminal src kinase protein 1	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0477	0.8566	1
Trichomonas vaginalis	TKL family protein kinase	0.0477	0.8566	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.053 uM	Competitive inhibition of p38alpha MAP kinase (unknown origin) in presence of 100 uM ATP	ChEMBL.	24131218
IC50 (binding)	= 38.08 uM	Inhibition of p38alpha MAP kinase in human whole blood assessed as inhibition of LPS-induced TNFalpha release by ELISA	ChEMBL.	24131218

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3087480

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1844386