Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0556 | 0.0556 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.0053 | 0.0593 | 0.0593 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0052 | 0.0556 | 0.0556 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0478 | 1 | 1 |
Plasmodium falciparum | transporter, putative | 0.0053 | 0.0593 | 1 |
Onchocerca volvulus | 0.0052 | 0.0556 | 0.0386 | |
Brugia malayi | Cathepsin L-like precursor | 0.0052 | 0.0556 | 0.0556 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0593 | 0.0424 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0052 | 0.0556 | 0.0556 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0556 | 0.0556 |
Onchocerca volvulus | 0.0052 | 0.0556 | 0.0386 | |
Onchocerca volvulus | 0.0052 | 0.0556 | 0.0386 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0052 | 0.0556 | 0.0556 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0035 | 0.0177 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0052 | 0.0556 | 0.9367 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Onchocerca volvulus | 0.0052 | 0.0556 | 0.0386 | |
Brugia malayi | Cathepsin L-like precursor | 0.0052 | 0.0556 | 0.0556 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0478 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0052 | 0.0556 | 0.0556 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0593 | 0.0424 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0052 | 0.0556 | 1 |
Plasmodium vivax | metal transporter, putative | 0.0053 | 0.0593 | 1 |
Onchocerca volvulus | 0.0052 | 0.0556 | 0.0386 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Plasmodium vivax | vivapain-2 | 0.0052 | 0.0556 | 0.9367 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.0431 | 0.8953 | 0.8953 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.0431 | 0.8953 | 0.8953 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0052 | 0.0556 | 0.0556 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0478 | 1 | 1 |
Onchocerca volvulus | 0.0052 | 0.0556 | 0.0386 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0035 | 0.0177 | 0.0177 |
Echinococcus granulosus | cathepsin l1 | 0.0035 | 0.0177 | 0.0177 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0035 | 0.0177 | 0.0177 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0052 | 0.0556 | 0.0556 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0478 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0052 | 0.0556 | 0.0386 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0478 | 1 | 1 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0478 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0052 | 0.0556 | 0.0386 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0052 | 0.0556 | 0.0556 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Echinococcus granulosus | divalent metal transporter DMT1B | 0.0053 | 0.0593 | 0.0593 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0556 | 0.0556 |
Echinococcus granulosus | lysosomal protective protein | 0.0478 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0556 | 0.0556 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0052 | 0.0556 | 0.9367 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0052 | 0.0556 | 0.0386 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0052 | 0.0556 | 0.0556 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0556 | 0.0556 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0556 | 0.0556 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0478 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Onchocerca volvulus | 0.0052 | 0.0556 | 0.0386 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0052 | 0.0556 | 0.0556 |
Entamoeba histolytica | cysteine protease, putative | 0.0052 | 0.0556 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0052 | 0.0556 | 0.0556 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0052 | 0.0556 | 0.9367 |
Brugia malayi | cathepsin L-like precursor | 0.0035 | 0.0177 | 0.0177 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0035 | 0.0177 | 0.0177 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0052 | 0.0556 | 0.0556 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0052 | 0.0556 | 0.0556 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0478 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0035 | 0.0177 | 0.0177 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0556 | 0.0556 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0556 | 0.0556 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0556 | 0.0556 |
Onchocerca volvulus | Protein Malvolio homolog | 0.0053 | 0.0593 | 0.0424 |
Echinococcus multilocularis | lysosomal protective protein | 0.0478 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0052 | 0.0556 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0035 | 0.0177 | 0.3182 |
Onchocerca volvulus | Cathepsin F homolog | 0.0052 | 0.0556 | 0.0386 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0052 | 0.0556 | 0.0556 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0052 | 0.0556 | 0.0556 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0052 | 0.0556 | 0.0556 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0052 | 0.0556 | 0.0556 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0052 | 0.0556 | 0.0386 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0556 | 0.0386 |
Loa Loa (eye worm) | ctsf protein | 0.0052 | 0.0556 | 0.0386 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0478 | 1 | 1 |
Mycobacterium leprae | DIVALENT CATION-TRANSPORT INTEGRAL MEMBRANE PROTEIN MNTH (BRAMP) (MRAMP) | 0.0033 | 0.0141 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0556 | 0.0556 |
Loa Loa (eye worm) | hypothetical protein | 0.0478 | 1 | 1 |
Schistosoma mansoni | lysosomal protective protein precursor (cathepsin A) (carboxypeptidase | 0.0047 | 0.0456 | 0.0456 |
Toxoplasma gondii | divalent metal transporter, putative | 0.0053 | 0.0593 | 1 |
Mycobacterium ulcerans | manganese transport protein MntH | 0.0053 | 0.0593 | 0.5 |
Echinococcus multilocularis | divalent metal transporter DMT1B | 0.0053 | 0.0593 | 0.0593 |
Brugia malayi | Cathepsin L-like precursor | 0.0052 | 0.0556 | 0.0556 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0052 | 0.0556 | 0.0556 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0052 | 0.0556 | 0.0556 |
Onchocerca volvulus | Cathepsin L homolog | 0.0052 | 0.0556 | 0.0386 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0478 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Mycobacterium tuberculosis | Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) | 0.0033 | 0.0141 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0052 | 0.0556 | 0.0556 |
Brugia malayi | NRAMP-like transporter K11G12.4 | 0.0053 | 0.0593 | 0.0593 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0035 | 0.0177 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0052 | 0.0556 | 1 |
Plasmodium vivax | vivapain-2 | 0.0052 | 0.0556 | 0.9367 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.0053 | 0.0593 | 0.0593 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0052 | 0.0556 | 0.0556 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0478 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0052 | 0.0556 | 0.0556 |
Loa Loa (eye worm) | fibroinase | 0.0052 | 0.0556 | 0.0386 |
Brugia malayi | Cathepsin L-like precursor | 0.0035 | 0.0177 | 0.0177 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 19.81 ug ml-1 | Antiamoebic activity against Entamoeba histolytica | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.