Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0449 | 0.9457 | 1 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0474 | 1 | 1 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0474 | 1 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0449 | 0.9457 | 0.9457 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0449 | 0.9457 | 1 |
Toxoplasma gondii | transitional endoplasmic reticulum ATPase, putative | 0.0283 | 0.5767 | 0.5767 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0449 | 0.9457 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.2024 | 0.3589 |
Trypanosoma cruzi | katanin, putative | 0.0024 | 0.0000041468 | 0.0000043848 |
Mycobacterium ulcerans | ATPase | 0.0283 | 0.5767 | 0.5 |
Brugia malayi | ATPase, AAA family protein | 0.0024 | 0.0000041468 | 0.0000073523 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0474 | 1 | 1 |
Trypanosoma cruzi | vacuolar protein sorting-associated protein 4, putative | 0.0024 | 0.0000041468 | 0.0000043848 |
Loa Loa (eye worm) | fidgetin protein | 0.0024 | 0.0000041468 | 0.0000073523 |
Brugia malayi | valosin containing protein | 0.0278 | 0.564 | 1 |
Loa Loa (eye worm) | VCP protein | 0.0196 | 0.3817 | 0.6768 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0449 | 0.9457 | 1 |
Trypanosoma cruzi | katanin-like protein, putative | 0.0024 | 0.0000041468 | 0.0000043848 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0474 | 1 | 1 |
Trichomonas vaginalis | 26S protease regulatory subunit S10b, putative | 0.0112 | 0.195 | 0.195 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0278 | 0.564 | 1 |
Brugia malayi | vps4b-prov protein | 0.0024 | 0.0000041468 | 0.0000073523 |
Brugia malayi | vesicle-fusing ATPase | 0.0278 | 0.564 | 1 |
Trypanosoma cruzi | metalloprotease, putative | 0.0024 | 0.0000041468 | 0.0000043848 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.2024 | 0.3589 |
Brugia malayi | transitional endoplasmic reticulum ATPase TER94, putative | 0.0196 | 0.3817 | 0.6768 |
Loa Loa (eye worm) | ATPase | 0.0024 | 0.0000041468 | 0.0000073523 |
Trypanosoma cruzi | katanin, putative | 0.0024 | 0.0000041468 | 0.0000043848 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0474 | 1 | 1 |
Trypanosoma cruzi | katanin, putative | 0.0024 | 0.0000041468 | 0.0000043848 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.564 | 1 |
Trichomonas vaginalis | proteasome-activating nucleotidase, putative | 0.0112 | 0.195 | 0.195 |
Trypanosoma cruzi | katanin, putative | 0.0024 | 0.0000041468 | 0.0000043848 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0449 | 0.9457 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.2024 | 0.3589 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0283 | 0.5767 | 0.5767 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0449 | 0.9457 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0196 | 0.3817 | 0.3817 |
Trypanosoma cruzi | katanin, putative | 0.0024 | 0.0000041468 | 0.0000043848 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0283 | 0.5767 | 0.5 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0196 | 0.3817 | 0.3817 |
Giardia lamblia | AAA family ATPase | 0.0283 | 0.5767 | 1 |
Trypanosoma brucei | Valosin-containing protein | 0.0449 | 0.9457 | 1 |
Trypanosoma cruzi | vacuolar transport protein 4A, putative | 0.0024 | 0.0000041468 | 0.0000043848 |
Trypanosoma cruzi | vesicular transport protein (CDC48 homologue), putative | 0.0024 | 0.0000041468 | 0.0000043848 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.