Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Fibulin-1 precursor | 0.0128 | 0.2325 | 1 |
Onchocerca volvulus | Arrow homolog | 0.0115 | 0.1957 | 1 |
Brugia malayi | astacin protease protein 30 | 0.005 | 0.0093 | 0.0398 |
Onchocerca volvulus | 0.005 | 0.0093 | 0.0473 | |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.1957 | 0.1957 |
Loa Loa (eye worm) | AStacin protease | 0.0248 | 0.5754 | 0.5754 |
Brugia malayi | zinc metalloproteinase toh-2 precursor | 0.005 | 0.0093 | 0.0398 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0128 | 0.2325 | 0.2325 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0396 | 1 | 1 |
Brugia malayi | Nematode astacin protease protein 30 | 0.005 | 0.0093 | 0.0398 |
Brugia malayi | Zinc metalloproteinase toh-2 precursor | 0.005 | 0.0093 | 0.0398 |
Brugia malayi | Nematode astacin protease protein 30 | 0.005 | 0.0093 | 0.0398 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0128 | 0.2325 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0396 | 1 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0128 | 0.2325 | 0.5 |
Loa Loa (eye worm) | zinc metalloproteinase toh-2 | 0.005 | 0.0093 | 0.0093 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0396 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.9539 | 0.9539 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.3285 | 0.3285 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0115 | 0.1957 | 0.1957 |
Loa Loa (eye worm) | DPY-31 protein | 0.005 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.2325 | 0.2325 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0115 | 0.1957 | 0.8416 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.1957 | 0.1957 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0128 | 0.2325 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 10.5 ug ml-1 | In vitro cytotoxicity was determined against L1210 leukemia cell from mouse. | ChEMBL. | 2299637 |
Survival (functional) | = 52 % | Percent survival of L1210 cells in suspension was determined after a dose of 10 microg/mL in mouse | ChEMBL. | 2299637 |
T/C (functional) | = 98 % | In vivo cytotoxicity was determined against P388 mouse leukemia cells expressed as % treated/control | ChEMBL. | 2299637 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.