Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Endothelin receptor ET-B | Starlite/ChEMBL | References |
Rattus norvegicus | Endothelin receptor ET-A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Endothelin receptor ET-B | 442 aa | 445 aa | 20.9 % | |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | Endothelin receptor ET-A | 426 aa | 412 aa | 20.1 % |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | Endothelin receptor ET-A | 426 aa | 412 aa | 21.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0107 | 0.2563 | 1 |
Trypanosoma brucei | endonuclease G, putative | 0.0064 | 0 | 0.5 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0064 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0107 | 0.2563 | 1 |
Trypanosoma cruzi | endonuclease G, putative | 0.0064 | 0 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0064 | 0 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0107 | 0.2563 | 0.2563 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0064 | 0 | 0.5 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0064 | 0 | 0.5 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0107 | 0.2563 | 0.2563 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.009 | 0.1553 | 0.6061 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0107 | 0.2563 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0107 | 0.2563 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0107 | 0.2563 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.009 | 0.1553 | 0.6061 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0107 | 0.2563 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0107 | 0.2563 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.2563 | 0.1195 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0107 | 0.2563 | 0.2563 |
Echinococcus granulosus | ectonucleotide | 0.009 | 0.1553 | 0.6061 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0107 | 0.2563 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0231 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.2563 | 0.1195 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0107 | 0.2563 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0231 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0107 | 0.2563 | 1 |
Echinococcus multilocularis | ectonucleotide | 0.009 | 0.1553 | 0.6061 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0107 | 0.2563 | 0.2563 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.2563 | 0.1195 |
Onchocerca volvulus | 0.0231 | 1 | 1 | |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0064 | 0 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0107 | 0.2563 | 0.2563 |
Trypanosoma cruzi | endonuclease G, putative | 0.0064 | 0 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0064 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0107 | 0.2563 | 1 |
Leishmania major | endonuclease G, putative | 0.0064 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.4 uM | In vitro inhibition of [125-I] labelled ET-1 endothelin binding to Endothelin B receptor in rat cerebellum | ChEMBL. | 10890162 |
IC50 (binding) | = 10 uM | In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay | ChEMBL. | 10890162 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.