Detailed information for compound 184714

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 339.428 | Formula: C21H25NO3
  • H donors: 1 H acceptors: 2 LogP: 4.26 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)C(=O)CCCCCCOc1ccc(cc1)c1ccccc1
  • InChi: 1S/C21H25NO3/c1-22-21(24)20(23)11-7-2-3-8-16-25-19-14-12-18(13-15-19)17-9-5-4-6-10-17/h4-6,9-10,12-15H,2-3,7-8,11,16H2,1H3,(H,22,24)
  • InChiKey: NCCVAHRKWSHQQH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histone deacetylase 1 Starlite/ChEMBL References
Homo sapiens histone deacetylase 9 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC3 Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei gambiense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi histone deacetylase 1 (HD1) Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi Histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Babesia bovis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium vivax histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Babesia bovis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Entamoeba histolytica histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei gambiense histone deacetylase 1,histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi histone deacetylase 3 (HD3) Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium vivax histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium parvum RPD3/HD1 histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium yoelii Histone deacetylase family, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum histone deactylase of possible bacterial origin with ankyrin repeats at the N-terminus Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium falciparum histone deacetylase 2 Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 3 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase hda2 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium falciparum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium vivax histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Toxoplasma gondii histone deacetylase HDAC1 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum ko:K06067 histone deacetylase 1/2, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Toxoplasma gondii histone deacetylase HDAC2 Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum IPR000286,Histone deacetylase superfamily;IPR013838,Beta tubulin, autoregulation binding site,domain-containing Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase 7A Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Giardia lamblia Histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum ko:K01463 Hdac3 [EC:3.5.1.-], putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum histone deacetylase HDA2/Rpd3p Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TK protein kinase 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK/FER protein kinase 0.0938 0.5574 0.5574
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0938 0.5574 0.5574
Entamoeba histolytica SH2 domain containing protein 0.0684 0.3929 0.3929
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0938 0.5574 0.5574
Onchocerca volvulus 0.1622 1 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0684 0.3929 0.3929
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0938 0.5574 0.5574
Entamoeba histolytica tyrosine kinase, putative 0.0938 0.5574 0.5574
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0938 0.5574 0.5574
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Echinococcus granulosus activated cdc42 kinase 1 0.0938 0.5574 0.5574
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0684 0.3929 0.3929
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Entamoeba histolytica tyrosine kinase, putative 0.0938 0.5574 0.5574
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Entamoeba histolytica tyrosine kinase, putative 0.0938 0.5574 0.5574
Echinococcus granulosus integrin linked protein kinase 0.0938 0.5574 0.5574
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Echinococcus granulosus suppressor of cytokine signaling 6 0.0684 0.3929 0.3929
Brugia malayi hypothetical protein 0.0684 0.3929 0.3929
Schistosoma mansoni tensin-related 0.0684 0.3929 0.3929
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Schistosoma mansoni tensin-related 0.0684 0.3929 0.3929
Entamoeba histolytica hypothetical protein 0.0938 0.5574 0.5574
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0938 0.5574 0.5574
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0938 0.5574 0.5574
Entamoeba histolytica ankyrin repeat protein 0.0938 0.5574 0.5574
Echinococcus granulosus fibroblast growth factor receptor 4 0.0938 0.5574 0.5574
Giardia lamblia Kinase, NEK 0.0938 0.5574 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.1622 1 1
Plasmodium falciparum protein kinase, putative 0.0938 0.5574 1
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0938 0.5574 0.5574
Echinococcus granulosus retinal guanylyl cyclase 2 0.0938 0.5574 0.5574
Schistosoma mansoni tyrosine kinase 0.1622 1 1
Echinococcus granulosus N chimaerin 0.0684 0.3929 0.3929
Onchocerca volvulus 0.1622 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0938 0.5574 0.5574
Toxoplasma gondii protein kinase 0.0938 0.5574 1
Schistosoma mansoni protein kinase 0.0938 0.5574 0.5574
Echinococcus granulosus SHC transforming protein 3 0.0684 0.3929 0.3929
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Echinococcus multilocularis activated cdc42 kinase 1 0.0938 0.5574 0.5574
Onchocerca volvulus 0.1622 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0684 0.3929 0.3929
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.1622 1 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0684 0.3929 0.3929
Echinococcus granulosus c src tyrosine kinase 0.1622 1 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Loa Loa (eye worm) TK/FER protein kinase 0.0938 0.5574 0.5574
Echinococcus multilocularis receptor type guanylyl cyclase 0.0938 0.5574 0.5574
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK/ALK protein kinase 0.0938 0.5574 0.5574
Entamoeba histolytica protein kinase, putative 0.0938 0.5574 0.5574
Loa Loa (eye worm) hypothetical protein 0.0684 0.3929 0.3929
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0938 0.5574 0.5574
Onchocerca volvulus 0.0938 0.5574 0.2709
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Echinococcus multilocularis protein kinase 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Echinococcus multilocularis tyrosine protein kinase csk 0.0938 0.5574 0.5574
Entamoeba histolytica tyrosine kinase, putative 0.0938 0.5574 0.5574
Loa Loa (eye worm) hypothetical protein 0.0938 0.5574 0.5574
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Entamoeba histolytica SH2-protein kinase domain containing protein 0.1622 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0938 0.5574 0.5574
Echinococcus granulosus epidermal growth factor receptor 0.0938 0.5574 0.5574
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Entamoeba histolytica hypothetical protein 0.0938 0.5574 0.5574
Onchocerca volvulus 0.1622 1 1
Echinococcus granulosus SH2 motif 0.0684 0.3929 0.3929
Schistosoma mansoni serine/threonine protein kinase 0.0938 0.5574 0.5574
Plasmodium vivax tyrosine kinase-like protein, putative 0.0938 0.5574 1
Trichomonas vaginalis conserved hypothetical protein 0.0938 0.5574 1
Loa Loa (eye worm) TK/FER protein kinase 0.0938 0.5574 0.5574
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0684 0.3929 0.3929
Echinococcus granulosus suppressor of cytokine signaling 7 0.0684 0.3929 0.3929
Echinococcus granulosus tensin 0.0684 0.3929 0.3929
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0684 0.3929 0.3929
Echinococcus multilocularis tensin 0.0684 0.3929 0.3929
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.1622 1 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Trichomonas vaginalis STE family protein kinase 0.0938 0.5574 1
Onchocerca volvulus 0.0938 0.5574 0.2709
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0938 0.5574 0.5574
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.1622 1 1
Loa Loa (eye worm) TK/CSK protein kinase 0.0938 0.5574 0.5574
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Echinococcus multilocularis kinase suppressor of Ras 1 0.0938 0.5574 0.5574
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0938 0.5574 0.5574
Entamoeba histolytica cysteine surface protein, putative 0.0938 0.5574 0.5574
Brugia malayi SH2 domain containing protein 0.0684 0.3929 0.3929
Loa Loa (eye worm) TK/FER protein kinase 0.1622 1 1
Onchocerca volvulus 0.1622 1 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0684 0.3929 0.3929
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Entamoeba histolytica protein kinase, putative 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK/INSR protein kinase 0.0938 0.5574 0.5574
Echinococcus granulosus protein kinase 0.0938 0.5574 0.5574
Loa Loa (eye worm) hypothetical protein 0.0684 0.3929 0.3929
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0938 0.5574 0.5574
Loa Loa (eye worm) hypothetical protein 0.0684 0.3929 0.3929
Entamoeba histolytica protein kinase, putative 0.0938 0.5574 0.5574
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Brugia malayi Protein kinase domain containing protein 0.1622 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Schistosoma mansoni tyrosine kinase 0.1622 1 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0938 0.5574 0.5574
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0684 0.3929 0.3929
Onchocerca volvulus Tyrosine kinase homolog 0.0938 0.5574 0.2709
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Loa Loa (eye worm) serine/threonine protein kinase 0.0938 0.5574 0.5574
Entamoeba histolytica hypothetical protein 0.0938 0.5574 0.5574
Brugia malayi Tyrosine-protein kinase PR2 0.0938 0.5574 0.5574
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.1622 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0938 0.5574 0.5574
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1622 1 1
Loa Loa (eye worm) hypothetical protein 0.0938 0.5574 0.5574
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0938 0.5574 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Brugia malayi Raf kinase 0.0938 0.5574 0.5574
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK/ABL protein kinase 0.1622 1 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0938 0.5574 0.5574
Echinococcus multilocularis tyrosine protein kinase Srms 0.1622 1 1
Loa Loa (eye worm) TK protein kinase 0.0938 0.5574 0.5574
Echinococcus granulosus tyrosine protein kinase shark 0.1622 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Plasmodium falciparum protein kinase, putative 0.0938 0.5574 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.1622 1 1
Entamoeba histolytica hypothetical protein 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Echinococcus granulosus insulin receptor 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK/FER protein kinase 0.1622 1 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0684 0.3929 0.3929
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0938 0.5574 0.5574
Trypanosoma cruzi protein kinase, putative 0.0938 0.5574 1
Entamoeba histolytica tyrosine kinase, putative 0.0938 0.5574 0.5574
Echinococcus multilocularis tyrosine protein kinase pr2 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK protein kinase 0.0938 0.5574 0.5574
Schistosoma mansoni tensin 0.0684 0.3929 0.3929
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Echinococcus multilocularis tyrosine protein kinase 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK/FER protein kinase 0.1622 1 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Loa Loa (eye worm) hypothetical protein 0.0938 0.5574 0.5574
Schistosoma mansoni SH2A 0.0684 0.3929 0.3929
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Schistosoma mansoni tyrosine kinase 0.1622 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.1622 1 1
Entamoeba histolytica tyrosin kinase, putative 0.0938 0.5574 0.5574
Entamoeba histolytica tyrosine kinase, putative 0.0938 0.5574 0.5574
Loa Loa (eye worm) hypothetical protein 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK/FER protein kinase 0.1622 1 1
Entamoeba histolytica protein kinase, putative 0.0684 0.3929 0.3929
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Entamoeba histolytica tyrosine kinase, putative 0.0938 0.5574 0.5574
Entamoeba histolytica tyrosine kinase, putative 0.0938 0.5574 0.5574
Brugia malayi Receptor family ligand binding region containing protein 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0684 0.3929 0.3929
Entamoeba histolytica tyrosin kinase, putative 0.0938 0.5574 0.5574
Loa Loa (eye worm) hypothetical protein 0.0684 0.3929 0.3929
Loa Loa (eye worm) TK/FER protein kinase 0.0938 0.5574 0.5574
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK/FER protein kinase 0.1622 1 1
Giardia lamblia Kinase 0.0938 0.5574 1
Echinococcus granulosus receptor type guanylyl cyclase 0.0938 0.5574 0.5574
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Schistosoma mansoni tyrosine kinase 0.1622 1 1
Giardia lamblia Protein 21.1 0.0938 0.5574 1
Trichomonas vaginalis conserved hypothetical protein 0.0938 0.5574 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Schistosoma mansoni tyrosine kinase 0.1622 1 1
Brugia malayi Tyrosine-protein kinase abl-1 0.1622 1 1
Brugia malayi Variant SH3 domain containing protein 0.0684 0.3929 0.3929
Schistosoma mansoni GTPase activating protein 0.0684 0.3929 0.3929
Loa Loa (eye worm) TK/ROR protein kinase 0.0938 0.5574 0.5574
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Trichomonas vaginalis conserved hypothetical protein 0.0938 0.5574 1
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Echinococcus granulosus tyrosine protein kinase 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK/FER protein kinase 0.0938 0.5574 0.5574
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1622 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0938 0.5574 0.5574
Loa Loa (eye worm) protein kinase domain-containing protein 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK/FER protein kinase 0.1622 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0684 0.3929 0.3929
Leishmania major hypothetical protein, conserved 0.0938 0.5574 1
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0938 0.5574 0.5574
Echinococcus granulosus tyrosine protein kinase Srms 0.1622 1 1
Loa Loa (eye worm) hypothetical protein 0.0938 0.5574 0.5574
Echinococcus multilocularis tyrosine protein kinase Blk 0.1622 1 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.1622 1 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Echinococcus granulosus tyrosine protein kinase csk 0.0938 0.5574 0.5574
Echinococcus granulosus tyrosine kinase 0.0938 0.5574 0.5574
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0684 0.3929 0.3929
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Entamoeba histolytica protein kinase, putative 0.0938 0.5574 0.5574
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0938 0.5574 0.5574
Schistosoma mansoni ephrin receptor 0.0938 0.5574 0.5574
Echinococcus multilocularis epidermal growth factor receptor 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK/FER protein kinase 0.1622 1 1
Onchocerca volvulus 0.0938 0.5574 0.2709
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0938 0.5574 0.5574
Schistosoma mansoni growth factor receptor-bound protein 0.0684 0.3929 0.3929
Entamoeba histolytica protein kinase, putative 0.0938 0.5574 0.5574
Loa Loa (eye worm) hypothetical protein 0.0684 0.3929 0.3929
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0938 0.5574 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Echinococcus multilocularis protein kinase 0.0938 0.5574 0.5574
Echinococcus multilocularis ephrin type A receptor 4 A 0.0938 0.5574 0.5574
Leishmania major protein kinase, putative 0.0938 0.5574 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0938 0.5574 0.5574
Echinococcus granulosus tyrosine protein kinase Btk29A 0.1622 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0938 0.5574 0.5574
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1622 1 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0938 0.5574 0.5574
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0938 0.5574 0.5574
Entamoeba histolytica hypothetical protein 0.0938 0.5574 0.5574
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0684 0.3929 0.3929
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0938 0.5574 0.5574
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0938 0.5574 0.5574
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0938 0.5574 0.5574
Echinococcus granulosus tyrosine protein kinase csk 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Echinococcus multilocularis SHC transforming protein 3 0.0684 0.3929 0.3929
Loa Loa (eye worm) TK/FER protein kinase 0.0938 0.5574 0.5574
Entamoeba histolytica protein kinase, putative 0.0938 0.5574 0.5574
Echinococcus multilocularis tyrosine protein kinase Abl 0.1622 1 1
Schistosoma mansoni serine/threonine RGC 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Loa Loa (eye worm) hypothetical protein 0.0938 0.5574 0.5574
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0938 0.5574 0.5574
Brugia malayi Furin-like cysteine rich region family protein 0.0938 0.5574 0.5574
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.1622 1 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0938 0.5574 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0684 0.3929 0.3929
Toxoplasma gondii STE kinase 0.0938 0.5574 1
Entamoeba histolytica hypothetical protein 0.0938 0.5574 0.5574
Schistosoma mansoni protein kinase 0.0938 0.5574 0.5574
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.1622 1 1
Echinococcus granulosus NCK adaptor protein 0.0684 0.3929 0.3929
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Entamoeba histolytica tyrosine kinase, putative 0.0938 0.5574 0.5574
Onchocerca volvulus 0.0938 0.5574 0.2709
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Entamoeba histolytica serine/threonine kinase, putative 0.0938 0.5574 0.5574
Loa Loa (eye worm) hypothetical protein 0.0938 0.5574 0.5574
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Echinococcus multilocularis 0.0684 0.3929 0.3929
Trichomonas vaginalis conserved hypothetical protein 0.0938 0.5574 1
Entamoeba histolytica protein kinase, putative 0.0938 0.5574 0.5574
Brugia malayi hypothetical protein 0.0938 0.5574 0.5574
Schistosoma mansoni adapter molecule crk 0.0684 0.3929 0.3929
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Loa Loa (eye worm) RGC/RGC protein kinase 0.0938 0.5574 0.5574
Schistosoma mansoni tyrosine protein kinase 0.0938 0.5574 0.5574
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0938 0.5574 0.5574
Trypanosoma cruzi protein kinase, putative 0.0938 0.5574 1
Trypanosoma brucei Pseudokinase, putative 0.0938 0.5574 1
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Echinococcus granulosus tyrosine kinase 0.1622 1 1
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0684 0.3929 0.3929
Echinococcus multilocularis c src tyrosine kinase 0.1622 1 1
Schistosoma mansoni protein tyrosine kinase 0.0938 0.5574 0.5574
Trypanosoma brucei protein kinase, putative 0.0938 0.5574 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Brugia malayi Protein kinase domain containing protein 0.1622 1 1
Schistosoma mansoni protein kinase 0.0938 0.5574 0.5574
Entamoeba histolytica tyrosine kinase, putative 0.0938 0.5574 0.5574
Brugia malayi Variant SH3 domain containing protein 0.0684 0.3929 0.3929
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Entamoeba histolytica hypothetical protein 0.0938 0.5574 0.5574
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Loa Loa (eye worm) RGC/RGC protein kinase 0.0938 0.5574 0.5574
Entamoeba histolytica ankyrin repeat protein 0.0938 0.5574 0.5574
Brugia malayi SH2 domain containing protein 0.0684 0.3929 0.3929
Entamoeba histolytica protein kinase, putative 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK/EGFR protein kinase 0.0938 0.5574 0.5574
Toxoplasma gondii protein kinase domain-containing protein 0.0938 0.5574 1
Entamoeba histolytica protein kinase, putative 0.0938 0.5574 0.5574
Brugia malayi SH2 domain containing protein 0.1622 1 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0938 0.5574 0.5574
Loa Loa (eye worm) hypothetical protein 0.0684 0.3929 0.3929
Loa Loa (eye worm) TK/FER protein kinase 0.1622 1 1
Loa Loa (eye worm) hypothetical protein 0.0684 0.3929 0.3929
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0938 0.5574 0.5574
Entamoeba histolytica hypothetical protein, conserved 0.0938 0.5574 0.5574
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0684 0.3929 0.3929
Entamoeba histolytica protein kinase, putative 0.0938 0.5574 0.5574
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0938 0.5574 0.5574
Plasmodium falciparum protein kinase, putative 0.0938 0.5574 1
Entamoeba histolytica tyrosine kinase, putative 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Entamoeba histolytica protein kinase, putative 0.0938 0.5574 0.5574
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0938 0.5574 1
Schistosoma mansoni shc transforming protein 0.0684 0.3929 0.3929
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0938 0.5574 0.5574
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0938 0.5574 1
Echinococcus multilocularis tyrosine kinase 0.1622 1 1
Entamoeba histolytica protein kinase, putative 0.0938 0.5574 0.5574
Brugia malayi Protein kinase domain containing protein 0.1622 1 1
Echinococcus multilocularis insulin receptor 0.0938 0.5574 0.5574
Loa Loa (eye worm) hypothetical protein 0.0684 0.3929 0.3929
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Entamoeba histolytica serine/threonine kinase, putative 0.0938 0.5574 0.5574
Loa Loa (eye worm) hypothetical protein 0.0684 0.3929 0.3929
Echinococcus multilocularis epidermal growth factor receptor 0.0938 0.5574 0.5574
Loa Loa (eye worm) hypothetical protein 0.0684 0.3929 0.3929
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Entamoeba histolytica receptor protein kinase, putative 0.0938 0.5574 0.5574
Brugia malayi bone morphogenetic protein type 1 receptor 0.0938 0.5574 0.5574
Onchocerca volvulus 0.0938 0.5574 0.2709
Schistosoma mansoni ephrin receptor 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK protein kinase 0.0938 0.5574 0.5574
Schistosoma mansoni growth factor receptor-bound protein 0.0684 0.3929 0.3929
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Echinococcus granulosus natriuretic peptide receptor 1 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK protein kinase 0.1622 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.1622 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0938 0.5574 1
Echinococcus granulosus SH2 domain containing protein 7 0.0684 0.3929 0.3929
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Echinococcus multilocularis activin receptor type 0.0938 0.5574 0.5574
Echinococcus multilocularis protein KINase family member (kin 25) 0.0938 0.5574 0.5574
Echinococcus multilocularis tyrosine protein kinase Fgr 0.1622 1 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0938 0.5574 0.5574
Loa Loa (eye worm) hypothetical protein 0.0938 0.5574 0.5574
Brugia malayi SH2 domain containing protein 0.0684 0.3929 0.3929
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Brugia malayi SRC-1 0.1622 1 1
Brugia malayi protein-tyrosine kinase 0.1622 1 1
Trichomonas vaginalis TK family protein kinase 0.0938 0.5574 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.1622 1 1
Brugia malayi tRNA modification GTPase TrmE family protein 0.0684 0.3929 0.3929
Plasmodium falciparum tyrosine kinase-like protein 0.0938 0.5574 1
Entamoeba histolytica tyrosin kinase, putative 0.0938 0.5574 0.5574
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Brugia malayi hypothetical protein 0.1622 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0938 0.5574 0.5574
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Echinococcus multilocularis protein tyrosine kinase 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Brugia malayi SH2 domain containing protein 0.0684 0.3929 0.3929
Brugia malayi Sex muscle abnormal protein 5 0.0684 0.3929 0.3929
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0684 0.3929 0.3929
Schistosoma mansoni suppressor of cytokine signaling 0.0684 0.3929 0.3929
Schistosoma mansoni protein kinase 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Echinococcus multilocularis tyrosine protein kinase Src64B 0.1622 1 1
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK protein kinase 0.0938 0.5574 0.5574
Echinococcus granulosus SH2 domain containing adapter protein F 0.0684 0.3929 0.3929
Schistosoma mansoni protein kinase 0.0938 0.5574 0.5574
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Brugia malayi SH2 domain containing protein 0.0684 0.3929 0.3929
Brugia malayi Variant SH3 domain containing protein 0.0684 0.3929 0.3929
Brugia malayi hypothetical protein 0.0938 0.5574 0.5574
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0684 0.3929 0.3929
Brugia malayi Protein kinase domain containing protein 0.1622 1 1
Entamoeba histolytica receptor protein kinase, putative 0.0938 0.5574 0.5574
Loa Loa (eye worm) hypothetical protein 0.0684 0.3929 0.3929
Echinococcus granulosus tyrosine protein kinase Blk 0.1622 1 1
Echinococcus granulosus tyrosine protein kinase pr2 0.0938 0.5574 0.5574
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0938 0.5574 0.5574
Plasmodium falciparum tyrosine kinase-like protein 0.0938 0.5574 1
Loa Loa (eye worm) hypothetical protein 0.0684 0.3929 0.3929
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1622 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0938 0.5574 0.5574
Echinococcus multilocularis FL cytokine receptor 0.0938 0.5574 0.5574
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Trichomonas vaginalis CAMK family protein kinase 0.0938 0.5574 1
Echinococcus multilocularis natriuretic peptide receptor 1 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0938 0.5574 0.2709
Entamoeba histolytica hypothetical protein 0.0938 0.5574 0.5574
Echinococcus multilocularis raf serine:threonine protein kinase 0.0938 0.5574 0.5574
Plasmodium vivax protein kinase, putative 0.0938 0.5574 1
Brugia malayi STAT protein, DNA binding domain containing protein 0.0684 0.3929 0.3929
Schistosoma mansoni protein kinase 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK protein kinase 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Schistosoma mansoni vav2 0.0684 0.3929 0.3929
Echinococcus multilocularis SH2 motif 0.0684 0.3929 0.3929
Leishmania major protein kinase, putative 0.0938 0.5574 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.1622 1 1
Loa Loa (eye worm) hypothetical protein 0.0684 0.3929 0.3929
Loa Loa (eye worm) hypothetical protein 0.0684 0.3929 0.3929
Echinococcus granulosus tyrosine protein kinase Src64B 0.1622 1 1
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0938 0.5574 0.2709
Entamoeba histolytica protein kinase, putative 0.0938 0.5574 0.5574
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0938 0.5574 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.1622 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0938 0.5574 0.5574
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0684 0.3929 0.3929
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0938 0.5574 0.5574
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0684 0.3929 0.3929
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Echinococcus multilocularis NCK adaptor protein 0.0684 0.3929 0.3929
Echinococcus multilocularis tyrosine kinase 0.0938 0.5574 0.5574
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Echinococcus granulosus ephrin type A receptor 4 A 0.0938 0.5574 0.5574
Echinococcus granulosus tyrosine protein kinase ABL1 0.1622 1 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0684 0.3929 0.3929
Trichomonas vaginalis AGC family protein kinase 0.0938 0.5574 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Entamoeba histolytica hypothetical protein 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK protein kinase 0.0938 0.5574 0.5574
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0938 0.5574 0.5574
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Loa Loa (eye worm) hypothetical protein 0.0938 0.5574 0.5574
Schistosoma mansoni protein kinase 0.0938 0.5574 0.5574
Trichomonas vaginalis protein kinase atn1, putative 0.0938 0.5574 1
Trichomonas vaginalis protein tyrosine kinase, putative 0.0938 0.5574 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0938 0.5574 0.5574
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0938 0.5574 0.5574
Onchocerca volvulus 0.0938 0.5574 0.2709
Loa Loa (eye worm) TK protein kinase 0.0938 0.5574 0.5574
Entamoeba histolytica protein kinase, putative 0.0938 0.5574 0.5574
Schistosoma mansoni tyrosine kinase 0.1622 1 1
Echinococcus multilocularis tensin 0.0684 0.3929 0.3929
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Entamoeba histolytica serine/threonine kinase, putative 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Schistosoma mansoni protein kinase 0.0938 0.5574 0.5574
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0684 0.3929 0.3929
Schistosoma mansoni signal transduction protein lnk-related 0.0684 0.3929 0.3929
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0938 0.5574 0.5574
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0938 0.5574 0.5574
Loa Loa (eye worm) hypothetical protein 0.0938 0.5574 0.5574
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0938 0.5574 1
Entamoeba histolytica protein kinase, putative 0.0938 0.5574 0.5574
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Trichomonas vaginalis conserved hypothetical protein 0.0938 0.5574 1
Entamoeba histolytica protein kinase, putative 0.0938 0.5574 0.5574
Trichomonas vaginalis conserved hypothetical protein 0.0938 0.5574 1
Entamoeba histolytica serine/threonine kinase, putative 0.0938 0.5574 0.5574
Echinococcus granulosus tyrosine protein kinase Fyn 0.1622 1 1
Echinococcus granulosus protein tyrosine kinase 0.0938 0.5574 0.5574
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Loa Loa (eye worm) TK/RYK protein kinase 0.0938 0.5574 0.5574
Schistosoma mansoni nck2/grb4 0.0684 0.3929 0.3929
Echinococcus multilocularis tyrosine protein kinase shark 0.1622 1 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.1622 1 1
Brugia malayi ephrin receptor 1 precursor 0.0938 0.5574 0.5574
Brugia malayi SH2 domain containing protein 0.1622 1 1
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0938 0.5574 0.5574
Brugia malayi Tensin 0.0684 0.3929 0.3929
Brugia malayi cytokine inducible SH2-containing protein 5 0.0684 0.3929 0.3929
Trichomonas vaginalis conserved hypothetical protein 0.0938 0.5574 1
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Echinococcus multilocularis heat shock protein 70 0.0938 0.5574 0.5574
Echinococcus multilocularis SH2 motif 0.0684 0.3929 0.3929
Onchocerca volvulus 0.0938 0.5574 0.2709
Loa Loa (eye worm) SH2 domain-containing protein 0.0684 0.3929 0.3929
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0938 0.5574 0.5574
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0684 0.3929 0.3929
Onchocerca volvulus 0.0938 0.5574 0.2709
Entamoeba histolytica protein kinase domain containing protein 0.0938 0.5574 0.5574
Brugia malayi RhoGAP domain containing protein 0.0684 0.3929 0.3929
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK/DDR protein kinase 0.0938 0.5574 0.5574
Schistosoma mansoni tensin 0.0684 0.3929 0.3929
Schistosoma mansoni protein kinase 0.0938 0.5574 0.5574
Schistosoma mansoni hypothetical protein 0.0684 0.3929 0.3929
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0938 0.5574 0.5574
Echinococcus granulosus hypothetical protein 0.0684 0.3929 0.3929
Echinococcus multilocularis tyrosine protein kinase csk 0.0938 0.5574 0.5574
Echinococcus granulosus SH2 motif 0.0684 0.3929 0.3929
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0684 0.3929 0.3929
Brugia malayi SH2 domain containing protein 0.0684 0.3929 0.3929
Echinococcus granulosus tyrosine protein kinase Fps85D 0.1622 1 1
Loa Loa (eye worm) TK/Met protein kinase 0.0938 0.5574 0.5574
Echinococcus granulosus expressed conserved protein 0.0684 0.3929 0.3929
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0938 0.5574 0.5574
Echinococcus granulosus raf serine:threonine protein kinase 0.0938 0.5574 0.5574
Brugia malayi Immunoglobulin I-set domain containing protein 0.0938 0.5574 0.5574
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0938 0.5574 0.5574
Entamoeba histolytica hypothetical protein 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Schistosoma mansoni serine/threonine protein kinase 0.0938 0.5574 0.5574
Echinococcus multilocularis N chimaerin 0.0684 0.3929 0.3929
Echinococcus granulosus tyrosine protein kinase HCK 0.0938 0.5574 0.5574
Echinococcus granulosus growth factor receptor bound protein 2 0.0684 0.3929 0.3929
Trypanosoma brucei Flagellum attachment zone protein 20 0.0938 0.5574 1
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0684 0.3929 0.3929
Loa Loa (eye worm) hypothetical protein 0.0938 0.5574 0.5574
Schistosoma mansoni hypothetical protein 0.0684 0.3929 0.3929
Schistosoma mansoni protein kinase 0.0938 0.5574 0.5574
Echinococcus multilocularis integrin linked protein kinase 0.0938 0.5574 0.5574
Schistosoma mansoni tensin 0.0684 0.3929 0.3929
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0938 0.5574 0.5574
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK/FER protein kinase 0.0938 0.5574 0.5574
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0684 0.3929 0.3929
Loa Loa (eye worm) SH2 domain-containing protein 0.0684 0.3929 0.3929
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Echinococcus granulosus epidermal growth factor receptor 0.0938 0.5574 0.5574
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0938 0.5574 0.5574
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0938 0.5574 0.5574
Brugia malayi integrin-linked kinase 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK/ACK protein kinase 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK/FAK protein kinase 0.0938 0.5574 0.5574
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0938 0.5574 0.5574
Entamoeba histolytica serine/threonine kinase, putative 0.0938 0.5574 0.5574
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0938 0.5574 0.5574
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0938 0.5574 1
Onchocerca volvulus 0.1622 1 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Echinococcus multilocularis SH2 domain containing protein 7 0.0684 0.3929 0.3929
Loa Loa (eye worm) hypothetical protein 0.0684 0.3929 0.3929
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Echinococcus multilocularis signal transduction protein lnk realted 0.0684 0.3929 0.3929
Plasmodium vivax tyrosine kinase-like protein, putative 0.0938 0.5574 1
Schistosoma mansoni protein kinase 0.0938 0.5574 0.5574
Echinococcus granulosus signal transduction protein lnk realted 0.0684 0.3929 0.3929
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Brugia malayi C-terminal src kinase protein 1 0.0938 0.5574 0.5574
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Loa Loa (eye worm) STAT protein 0.0684 0.3929 0.3929
Entamoeba histolytica protein kinase, putative 0.0938 0.5574 0.5574
Echinococcus granulosus tyrosine kinase 0.1622 1 1
Echinococcus granulosus tyrosine protein kinase csk 0.0938 0.5574 0.5574
Brugia malayi Variant SH3 domain containing protein 0.0684 0.3929 0.3929
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0684 0.3929 0.3929
Echinococcus granulosus activin receptor type 0.0938 0.5574 0.5574
Entamoeba histolytica hypothetical protein 0.0938 0.5574 0.5574
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1622 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0684 0.3929 0.3929
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0938 0.5574 1
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Brugia malayi SH2 domain containing protein 0.0684 0.3929 0.3929
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0684 0.3929 0.3929
Schistosoma mansoni hypothetical protein 0.0938 0.5574 0.5574
Brugia malayi Guanylyl cyclase protein 23 0.0938 0.5574 0.5574
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Echinococcus granulosus kinase suppressor of Ras 1 0.0938 0.5574 0.5574
Entamoeba histolytica serine/threonine kinase, putative 0.0938 0.5574 0.5574
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Echinococcus multilocularis tyrosine protein kinase csk 0.0938 0.5574 0.5574
Schistosoma mansoni serine/threonine protein kinase 0.0938 0.5574 0.5574
Loa Loa (eye worm) hypothetical protein 0.1622 1 1
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Loa Loa (eye worm) TK/FER protein kinase 0.1622 1 1
Schistosoma mansoni suppressor of cytokine signaling 0.0684 0.3929 0.3929
Echinococcus multilocularis SH2 motif 0.0684 0.3929 0.3929
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0938 0.5574 0.5574
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0938 0.5574 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0938 0.5574 0.5574
Loa Loa (eye worm) SRC-1 0.1622 1 1
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0938 0.5574 0.5574
Entamoeba histolytica tyrosine kinase, putative 0.0938 0.5574 0.5574
Onchocerca volvulus 0.0938 0.5574 0.2709
Entamoeba histolytica protein kinase, putative 0.0938 0.5574 0.5574
Entamoeba histolytica protein kinase, putative 0.0938 0.5574 0.5574
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0938 0.5574 0.5574
Loa Loa (eye worm) hypothetical protein 0.0938 0.5574 0.5574
Echinococcus granulosus retinal guanylyl cyclase 2 0.0938 0.5574 0.5574
Loa Loa (eye worm) TK protein kinase 0.0938 0.5574 0.5574
Echinococcus multilocularis transfer RNA-Thr 0.0938 0.5574 0.5574
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0938 0.5574 0.5574
Giardia lamblia Kinase, NEK 0.0938 0.5574 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0938 0.5574 0.5574
Brugia malayi Protein kinase domain containing protein 0.0938 0.5574 0.5574
Schistosoma mansoni serine/threonine protein kinase 0.0938 0.5574 0.5574
Echinococcus granulosus activated cdc42 kinase 1 0.0938 0.5574 0.5574
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0684 0.3929 0.3929
Trichomonas vaginalis TKL family protein kinase 0.0938 0.5574 1
Schistosoma mansoni tyrosine kinase 0.0938 0.5574 0.5574
Entamoeba histolytica tyrosin kinase, putative 0.0938 0.5574 0.5574
Entamoeba histolytica tyrosine kinase, putative 0.0938 0.5574 0.5574

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.11 nM Inhibitory activity against mixture of histone deacetylase 1 (HDAC1) and histone deacetylase 2 (HDAC2) from nuclear extraction of K562 erythroleukemia cells. ChEMBL. 12951120
IC50 (binding) = 0.11 nM Inhibitory activity against mixture of histone deacetylase 1 (HDAC1) and histone deacetylase 2 (HDAC2) from nuclear extraction of K562 erythroleukemia cells. ChEMBL. 12951120
IC50 (binding) = 110 nM Inhibition of HDAC (unknown origin) ChEMBL. 18053726
IC50 (binding) = 0.11 uM Inhibitory activity against Histone deacetylase(HDAC) in K 562 erythroleukemia cells ChEMBL. 14592473
IC50 (binding) = 0.11 uM Inhibition of HDAC from human K562 cells ChEMBL. 18247554
IC50 (binding) = 0.11 uM Inhibitory activity against Histone deacetylase(HDAC) in K 562 erythroleukemia cells ChEMBL. 14592473
IC50 (binding) = 0.11 uM Inhibition of HDAC from human K562 cells ChEMBL. 18247554

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

4 literature references were collected for this gene.

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