Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | alkB, alkylation repair homolog 3 (E. coli) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | Get druggable targets OG5_134523 | All targets in OG5_134523 |
Mycobacterium tuberculosis | Conserved hypothetical protein | Get druggable targets OG5_134523 | All targets in OG5_134523 |
Mycobacterium leprae | Conserved hypothetical protein | Get druggable targets OG5_134523 | All targets in OG5_134523 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.023 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0681 | 0.0587 | 0.5 |
Trypanosoma cruzi | GUP1, putative | 0.0681 | 0.0587 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.0681 | 0.0587 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0681 | 0.0587 | 0.5 |
Trichomonas vaginalis | transmembrane protein nessy, putative | 0.0681 | 0.0587 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0681 | 0.0587 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.0681 | 0.0587 | 0.5 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.0681 | 0.0587 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0681 | 0.0587 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.0681 | 0.0587 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0681 | 0.0587 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0681 | 0.0587 | 0.5 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.0681 | 0.0587 | 0.5 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0681 | 0.0587 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.722 | 0.9112 | 0.9057 |
Loa Loa (eye worm) | MBOAT family protein | 0.7901 | 1 | 1 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | 0.7901 | 1 | 1 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.0681 | 0.0587 | 0.5 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0681 | 0.0587 | 0.5 |
Treponema pallidum | alginate O-acetylation protein (algI) | 0.0681 | 0.0587 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0681 | 0.0587 | 0.5 |
Trypanosoma cruzi | GUP1, putative | 0.0681 | 0.0587 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0681 | 0.0587 | 0.5 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0681 | 0.0587 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.722 | 0.9112 | 0.9057 |
Trichomonas vaginalis | porcupine, putative | 0.0681 | 0.0587 | 0.5 |
Onchocerca volvulus | 0.0681 | 0.0587 | 0.5 | |
Leishmania major | glycerol uptake protein, putative | 0.0681 | 0.0587 | 0.5 |
Entamoeba histolytica | vacuolar protein sorting 26 | 0.0681 | 0.0587 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.023 | 0 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.7901 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0681 | 0.0587 | 0.5 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.0681 | 0.0587 | 0.5 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0681 | 0.0587 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0681 | 0.0587 | 0.5 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0681 | 0.0587 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.0681 | 0.0587 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.023 | 0 | 0.5 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | 0.7901 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.1 uM | Inhibition of demethylase activity of PCA-1 (unknown origin) using 3-methyl cytosine oligo DNA as substrate after 1 hr by RT-PCR analysis | ChEMBL. | 24461353 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.