Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 4D, cAMP-specific | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | thymidylate synthase | 0.0709 | 1 | 1 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0112 | 0.0511 | 0.0511 |
Echinococcus multilocularis | thymidylate synthase | 0.0709 | 1 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0098 | 0.0296 | 0.0296 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0709 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0709 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0511 | 0.0222 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0709 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0709 | 1 | 1 |
Onchocerca volvulus | 0.0709 | 1 | 0.5 | |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0709 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0338 | 0.4097 | 0.3917 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0709 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0709 | 1 | 0.5 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0112 | 0.0511 | 0.0511 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0112 | 0.0511 | 0.0511 |
Echinococcus granulosus | thymidylate synthase | 0.0709 | 1 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0112 | 0.0511 | 0.0511 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0098 | 0.0296 | 0.0296 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0709 | 1 | 0.5 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0112 | 0.0511 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0338 | 0.4097 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0709 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0709 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11 uM | Inhibition of cAMP phosphodiesterase preparation from bovine heart at a substrate concentration of 0.14 microM | ChEMBL. | 6245211 |
IC50 (binding) | = 25 uM | Inhibition of cAMP phosphodiesterase preparation from rabbit lung at a substrate concentration of 0.14 microM | ChEMBL. | 6245211 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.