Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0038 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0226 | 0.2557 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0226 | 0.2557 | 0.2557 |
Echinococcus multilocularis | sodium channel protein | 0.0086 | 0.0652 | 0.0652 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0771 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0226 | 0.2557 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0038 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0226 | 0.2557 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0038 | 0 | 0.5 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0226 | 0.2557 | 0.2557 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0133 | 0.13 | 0.5083 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Echinococcus granulosus | sodium channel protein | 0.0086 | 0.0652 | 0.0652 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0086 | 0.0652 | 0.5 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Brugia malayi | MH2 domain containing protein | 0.0133 | 0.13 | 0.5083 |
Brugia malayi | Carboxylesterase family protein | 0.0226 | 0.2557 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.2557 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0226 | 0.2557 | 0.2557 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0086 | 0.0652 | 0.0652 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0038 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.2557 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0771 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0226 | 0.2557 | 0.2557 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0226 | 0.2557 | 0.2557 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0133 | 0.13 | 0.5083 |
Echinococcus multilocularis | acetylcholinesterase | 0.0226 | 0.2557 | 0.2557 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0226 | 0.2557 | 0.2557 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as Gs-mediated activation of forskolin-stimulated SPAP secretion incubated for 10 mins prior to forskolin challenge measured after 5 hrs by spectrophotometry | ChEMBL. | No reference | |
Activity (functional) | Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as Gi-mediated inhibition of forskolin-stimulated SPAP secretion incubated for 10 mins prior to forskolin challenge measured after 5 hrs in presence of 1 uM adenosine A1 receptor antagonist XAC by spectrophotometry | ChEMBL. | No reference | |
IC50 (functional) | = 6.72 | Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as Gi-mediated inhibition of forskolin-stimulated SPAP secretion incubated for 10 mins prior to forskolin challenge measured after 5 hrs by spectrophotometry | ChEMBL. | No reference |
Inhibition (functional) | = 99 % | Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as Gi-mediated inhibition of forskolin-stimulated SPAP secretion incubated for 10 mins prior to forskolin challenge measured after 5 hrs by spectrophotometry | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.