Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | alkB, alkylation repair homolog 3 (E. coli) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Conserved hypothetical protein | Get druggable targets OG5_134523 | All targets in OG5_134523 |
Mycobacterium ulcerans | hypothetical protein | Get druggable targets OG5_134523 | All targets in OG5_134523 |
Mycobacterium leprae | Conserved hypothetical protein | Get druggable targets OG5_134523 | All targets in OG5_134523 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0032 | 0.5 |
Echinococcus multilocularis | 5' AMP activated protein kinase catalytic | 0.0274 | 1 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0053 | 0.0032 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.023 | 0.804 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0032 | 0.5 |
Echinococcus granulosus | 5' AMP activated protein kinase catalytic | 0.0274 | 1 | 1 |
Plasmodium vivax | serine/threonine protein kinase KIN, putative | 0.0053 | 0.0032 | 0.5 |
Brugia malayi | putative serine/threonine kinase SADA gamma | 0.0053 | 0.0032 | 0.0032 |
Mycobacterium leprae | Conserved hypothetical protein | 0.023 | 0.804 | 0.5 |
Trypanosoma cruzi | SNF1-related protein kinases, putative | 0.0053 | 0.0032 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/AMPK protein kinase | 0.0274 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0032 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/BRSK protein kinase | 0.0053 | 0.0032 | 0.0032 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0032 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0032 | 0.5 |
Plasmodium falciparum | serine/threonine protein kinase KIN | 0.0053 | 0.0032 | 0.5 |
Giardia lamblia | Kinase, CAMK CAMKL | 0.0053 | 0.0032 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0032 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0032 | 0.5 |
Leishmania major | serine/threonine protein kinase, putative,protein kinase, putative | 0.0053 | 0.0032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0032 | 0.0032 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0032 | 0.5 |
Trypanosoma brucei | 5'-AMP-activated protein kinase catalytic subunit alpha, putative | 0.0053 | 0.0032 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0032 | 0.5 |
Trypanosoma cruzi | 5'-AMP-activated protein kinase catalytic subunit alpha, putative | 0.0053 | 0.0032 | 0.5 |
Giardia lamblia | Kinase, CAMK CAMKL | 0.0053 | 0.0032 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0032 | 0.5 |
Toxoplasma gondii | histone kinase SNF1, putative | 0.0053 | 0.0032 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0032 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0032 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0032 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0032 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0274 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0032 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0032 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0032 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.023 | 0.804 | 0.5 |
Leishmania major | protein kinase, putative,SNF1-related protein kinases, putative | 0.0053 | 0.0032 | 0.5 |
Trypanosoma brucei | SNF1-related protein kinases, putative | 0.0053 | 0.0032 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.3 uM | Inhibition of demethylase activity of PCA-1 (unknown origin) using 3-methyl cytosine oligo DNA as substrate after 1 hr by RT-PCR analysis | ChEMBL. | 24461353 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.