TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 415.507 | Formula: C24H21N3O2S
H donors: 2 H acceptors: 4 LogP: 4.29 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cccc(c1)c1nc(sc1c1ccnc(c1)NC(=O)c1ccccc1)C(O)C
InChi: 1S/C24H21N3O2S/c1-15-7-6-10-18(13-15)21-22(30-24(27-21)16(2)28)19-11-12-25-20(14-19)26-23(29)17-8-4-3-5-9-17/h3-14,16,28H,1-2H3,(H,25,26,29)
InChiKey: YNLQDEHIGSGIDP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 14	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	P38 map kinase family protein 2	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania infantum	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania donovani	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma congolense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma japonicum	ko:K04441 p38 MAP kinase, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania mexicana	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei gambiense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania braziliensis	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 14	360 aa	336 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	protein kinase, putative	0.0058	0.1086	0.2015
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0059	0.1184	0.011
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.1207	1
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	ankyrin repeat protein	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase, putative	0.0058	0.1086	0.2015
Loa Loa (eye worm)	SRC-1	0.0104	0.5389	0.4828
Leishmania major	protein kinase, putative	0.0059	0.1184	0.011
Loa Loa (eye worm)	TK/FER protein kinase	0.0104	0.5389	0.4828
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.1086	0.2015
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.1086	0.2015
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0074	0.2613	0.1713
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase domain containing protein	0.0059	0.1207	0.224
Plasmodium falciparum	protein kinase, putative	0.0059	0.1184	0.806
Entamoeba histolytica	serine/threonine kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0059	0.1207	0.224
Entamoeba histolytica	protein kinase , putative	0.0059	0.1207	0.224
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0104	0.5389	0.4828
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.1086	0.2015
Loa Loa (eye worm)	TK/FER protein kinase	0.0104	0.5389	0.4828
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0153	1	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0105	0.5487	0.4937
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0104	0.5389	0.4828
Schistosoma mansoni	tyrosine kinase	0.0104	0.5389	1
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1086	0.2015
Entamoeba histolytica	hypothetical protein	0.0058	0.1086	0.2015
Giardia lamblia	Aurora kinase	0.0059	0.1207	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0104	0.5389	0.4828
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0153	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.1086	0.2015
Schistosoma mansoni	tyrosine kinase	0.0104	0.5389	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0059	0.1184	0.011
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.1086	0.2015
Loa Loa (eye worm)	TK/FER protein kinase	0.0104	0.5389	0.4828
Brugia malayi	Protein kinase domain containing protein	0.0104	0.5389	0.4828
Entamoeba histolytica	ankyrin repeat protein	0.0058	0.1086	0.2015
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0104	0.5389	1
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1086	0.2015
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	tyrosin kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	tyrosin kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1086	0.2015
Entamoeba histolytica	tyrosin kinase, putative	0.0058	0.1086	0.2015
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0104	0.5389	0.4828
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0058	0.1086	0.2015
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0059	0.1184	0.806
Entamoeba histolytica	protein kinase domain containing protein	0.0059	0.1184	0.2197
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0059	0.1184	0.011
Entamoeba histolytica	tyrosin kinase, putative	0.0058	0.1086	0.2015
Loa Loa (eye worm)	TK/FER protein kinase	0.0104	0.5389	0.4828
Loa Loa (eye worm)	TK/FER protein kinase	0.0104	0.5389	0.4828
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.1086	0.2015
Loa Loa (eye worm)	AUR protein kinase	0.0059	0.1207	0.0136
Echinococcus granulosus	tyrosine protein kinase Blk	0.0104	0.5389	0.4828
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1086	0.2015
Loa Loa (eye worm)	AUR protein kinase	0.0059	0.1207	0.0136
Entamoeba histolytica	cysteine surface protein, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	hypothetical protein	0.0058	0.1086	0.2015
Brugia malayi	SRC-1	0.0104	0.5389	0.4828
Entamoeba histolytica	serine/threonine kinase, putative	0.0058	0.1086	0.2015
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0059	0.1184	0.011
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1086	0.2015
Schistosoma mansoni	tyrosine kinase	0.0104	0.5389	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0104	0.5389	0.4828
Entamoeba histolytica	hypothetical protein	0.0058	0.1086	0.2015
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0153	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	serine/threonine kinase, putative	0.0058	0.1086	0.2015
Schistosoma mansoni	protein kinase	0.0059	0.1184	0.0228
Loa Loa (eye worm)	TK/FER protein kinase	0.0104	0.5389	0.4828
Entamoeba histolytica	hypothetical protein	0.0058	0.1086	0.2015
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0059	0.1184	0.011
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1086	0.2015
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0104	0.5389	0.4828
Trypanosoma brucei	aurora B kinase	0.0059	0.1207	0.0136
Entamoeba histolytica	protein kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.1086	0.2015
Brugia malayi	Protein kinase domain containing protein	0.0104	0.5389	0.4828
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1086	0.2015
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0104	0.5389	0.4828
Brugia malayi	SH2 domain containing protein	0.0104	0.5389	0.4828
Echinococcus multilocularis	aurora kinase A	0.0059	0.1207	0.0136
Schistosoma mansoni	serine/threonine protein kinase	0.0059	0.1207	0.0282
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0104	0.5389	0.4828
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0104	0.5389	0.4828
Brugia malayi	SH2 domain containing protein	0.0104	0.5389	0.4828
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.1086	0.2015
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.1086	0.2015
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0104	0.5389	0.4828
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1086	0.2015
Toxoplasma gondii	aurora kinase	0.0059	0.1207	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0104	0.5389	0.4828
Schistosoma mansoni	tyrosine kinase	0.0104	0.5389	1
Brugia malayi	Protein kinase domain containing protein	0.0104	0.5389	0.4828
Schistosoma mansoni	protein kinase	0.0059	0.1207	0.0282
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0059	0.1207	0.224
Onchocerca volvulus		0.0104	0.5389	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0104	0.5389	0.4828
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0153	1	1
Entamoeba histolytica	hypothetical protein, conserved	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase, putative	0.0058	0.1086	0.2015
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0104	0.5389	0.4828
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0104	0.5389	0.4828
Entamoeba histolytica	hypothetical protein	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1086	0.2015
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0059	0.1207	0.0136
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0104	0.5389	0.4828
Echinococcus granulosus	tyrosine kinase	0.0104	0.5389	0.4828
Echinococcus multilocularis	c src tyrosine kinase	0.0104	0.5389	0.4828
Entamoeba histolytica	protein kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0104	0.5389	1
Trypanosoma cruzi	aurora B kinase, putative	0.0059	0.1207	0.0136
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.1086	0.2015
Echinococcus granulosus	activin receptor type	0.0059	0.1184	0.011
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0074	0.2613	0.1713
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.1086	0.2015
Loa Loa (eye worm)	hypothetical protein	0.0104	0.5389	0.4828
Brugia malayi	Protein kinase domain containing protein	0.0104	0.5389	0.4828
Echinococcus granulosus	mitogen activated protein kinase 14	0.0153	1	1
Entamoeba histolytica	receptor protein kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	hypothetical protein	0.0058	0.1086	0.2015
Entamoeba histolytica	receptor protein kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	hypothetical protein	0.0058	0.1086	0.2015
Onchocerca volvulus		0.0104	0.5389	1
Entamoeba histolytica	protein kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0059	0.1207	0.224
Echinococcus multilocularis	tyrosine protein kinase shark	0.0104	0.5389	0.4828
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1086	0.2015
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.1086	0.2015
Brugia malayi	Protein kinase domain containing protein	0.0104	0.5389	0.4828
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0104	0.5389	0.4828
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0153	1	1
Entamoeba histolytica	hypothetical protein	0.0058	0.1086	0.2015
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.1207	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0104	0.5389	0.4828
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1086	0.2015
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0104	0.5389	0.4828
Entamoeba histolytica	serine/threonine kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase, putative	0.0058	0.1086	0.2015
Brugia malayi	serine/threonine-protein kinase 6	0.0059	0.1207	0.0136
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.1086	0.2015
Loa Loa (eye worm)	TK/FER protein kinase	0.0104	0.5389	0.4828
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.1086	0.2015
Echinococcus multilocularis	activin receptor type	0.0059	0.1184	0.011
Echinococcus granulosus	tyrosine protein kinase Srms	0.0104	0.5389	0.4828
Echinococcus granulosus	c src tyrosine kinase	0.0104	0.5389	0.4828
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1086	0.2015
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0104	0.5389	0.4828
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0104	0.5389	0.4828
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1086	0.2015
Echinococcus granulosus	mitogen activated protein kinase 11	0.0153	1	1
Schistosoma mansoni	tyrosine kinase	0.0104	0.5389	1
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.1207	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0104	0.5389	0.4828
Entamoeba histolytica	hypothetical protein	0.0058	0.1086	0.2015
Echinococcus multilocularis	tyrosine kinase	0.0104	0.5389	0.4828
Schistosoma mansoni	tyrosine kinase	0.0104	0.5389	1
Brugia malayi	serine/threonine protein kinase 6	0.0059	0.1207	0.0136
Entamoeba histolytica	protein kinase, putative	0.0059	0.1207	0.224
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.1086	0.2015
Echinococcus granulosus	tyrosine kinase	0.0104	0.5389	0.4828
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0059	0.1207	0.0136
Entamoeba histolytica	protein kinase, putative	0.0058	0.1086	0.2015
Echinococcus granulosus	aurora kinase A	0.0059	0.1207	0.0136
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.1207	1
Loa Loa (eye worm)	AUR protein kinase	0.0059	0.1207	0.0136
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0104	0.5389	0.4828
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0104	0.5389	0.4828
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0104	0.5389	0.4828
Loa Loa (eye worm)	TK/FER protein kinase	0.0104	0.5389	0.4828
Trypanosoma brucei	protein kinase, putative	0.0059	0.1184	0.011
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.1086	0.2015
Leishmania major	protein kinase, putative	0.0059	0.1207	0.0136
Onchocerca volvulus		0.0104	0.5389	1
Onchocerca volvulus		0.0104	0.5389	1
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0059	0.1207	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0104	0.5389	0.4828
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0153	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.1086	0.2015
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0104	0.5389	0.4828
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1086	0.2015
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0153	1	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0104	0.5389	0.4828
Entamoeba histolytica	protein kinase, putative	0.0058	0.1086	0.2015
Loa Loa (eye worm)	TK protein kinase	0.0104	0.5389	0.4828
Entamoeba histolytica	serine/threonine kinase, putative	0.0058	0.1086	0.2015
Brugia malayi	protein-tyrosine kinase	0.0104	0.5389	0.4828
Onchocerca volvulus		0.0104	0.5389	1
Entamoeba histolytica	protein kinase, putative	0.0059	0.1207	0.224
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1086	0.2015
Entamoeba histolytica	hypothetical protein	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1086	0.2015
Schistosoma mansoni	protein kinase	0.0059	0.1184	0.0228
Entamoeba histolytica	protein kinase, putative	0.0058	0.1086	0.2015
Loa Loa (eye worm)	TK/ABL protein kinase	0.0104	0.5389	0.4828
Entamoeba histolytica	hypothetical protein	0.0058	0.1086	0.2015
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.1086	0.2015
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0104	0.5389	0.4828
Onchocerca volvulus		0.0104	0.5389	1
Entamoeba histolytica	protein kinase, putative	0.0058	0.1086	0.2015
Entamoeba histolytica	protein kinase, putative	0.0058	0.1086	0.2015
Brugia malayi	serine/threonine kinase 12	0.0059	0.1207	0.0136
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0104	0.5389	0.4828
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0104	0.5389	0.4828
Entamoeba histolytica	protein kinase, putative	0.0058	0.1086	0.2015
Loa Loa (eye worm)	TK/FER protein kinase	0.0104	0.5389	0.4828
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0058	0.1086	0.2015
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0059	0.1207	1
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0153	1	1
Brugia malayi	hypothetical protein	0.0104	0.5389	0.4828
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1086	0.2015
Entamoeba histolytica	serine/threonine kinase, putative	0.0058	0.1086	0.2015
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0153	1	1
Schistosoma mansoni	protein kinase	0.0059	0.1184	0.0228
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1086	0.2015
Entamoeba histolytica	tyrosine kinase, putative	0.0058	0.1086	0.2015

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 38 nM	Displacement of SKF86002 from recombinant human p38alpha by fluorescence-based assay	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3218364

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1851655