Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0024 | 0 | 0.5 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0024 | 0 | 0.5 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 0.8374 | 0.8374 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.01 | 0.5348 | 0.5348 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Entamoeba histolytica | protein kinase, putative | 0.0165 | 1 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0142 | 0.8374 | 0.8374 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0165 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0165 | 1 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0165 | 0.9995 | 0.9995 |
Entamoeba histolytica | protein kinase, putative | 0.0165 | 1 | 0.5 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Loa Loa (eye worm) | doublecortin family protein | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0 | 0.5 |
Brugia malayi | Doublecortin family protein | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0165 | 0.9995 | 0.9995 |
Brugia malayi | hypothetical protein | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.8374 | 0.8374 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 10 mg kg-1 | Ex vivo inhibition of LTB4 production was measured in dog blood | ChEMBL. | 1848292 |
IC50 (functional) | = 2.5 uM | In vitro inhibition of LTB4 production was measured in rat blood | ChEMBL. | 1848292 |
IC50 (functional) | = 21 uM | In vitro inhibition of PGE-2 production was measured in rat blood | ChEMBL. | 1848292 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.