Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0763 | 0.7141 | 0.8962 |
Loa Loa (eye worm) | hypothetical protein | 0.1036 | 1 | 1 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0137 | 0.0601 | 0.0754 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.0178 | 0.0178 |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.0178 | 0.0178 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0137 | 0.0601 | 0.0601 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0216 | 0.1427 | 0.1792 |
Toxoplasma gondii | hexokinase | 0.0096 | 0.0178 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.041 | 0.346 | 0.3772 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 0.0178 | 1 |
Schistosoma mansoni | hexokinase | 0.0096 | 0.0178 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.1427 | 0.1427 |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.0178 | 0.0178 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.0178 | 0.0178 |
Echinococcus multilocularis | hexokinase type 2 | 0.0096 | 0.0178 | 0.0178 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0705 | 0.654 | 0.654 |
Plasmodium falciparum | hexokinase | 0.0096 | 0.0178 | 0.5 |
Onchocerca volvulus | 0.0096 | 0.0178 | 0.2962 | |
Trypanosoma brucei | hexokinase | 0.0096 | 0.0178 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0331 | 0.2633 | 0.2633 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.1036 | 1 | 1 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0137 | 0.0601 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.041 | 0.346 | 0.4342 |
Leishmania major | hexokinase, putative | 0.0096 | 0.0178 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 0.0178 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0957 | 0.9173 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0137 | 0.0601 | 0.0655 |
Trypanosoma brucei | hexokinase | 0.0096 | 0.0178 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0096 | 0.0178 | 0.0223 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 0.0178 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0842 | 0.7968 | 0.7968 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.0178 | 0.0178 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0705 | 0.654 | 0.713 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 0.0178 | 0.0178 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0216 | 0.1427 | 0.1427 |
Trypanosoma brucei | hexokinase, putative | 0.0096 | 0.0178 | 0.5 |
Onchocerca volvulus | 0.0096 | 0.0178 | 0.2962 | |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 0.0178 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 0.0178 | 1 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0137 | 0.0601 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 0.0178 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0178 | 0.0178 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.0601 | 0.0601 |
Onchocerca volvulus | 0.0096 | 0.0178 | 0.2962 | |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0137 | 0.0601 | 0.0601 |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.0178 | 0.0178 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0178 | 0.0178 |
Leishmania major | hexokinase, putative | 0.0096 | 0.0178 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0096 | 0.0178 | 0.0178 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0705 | 0.654 | 0.654 |
Brugia malayi | hexokinase | 0.0096 | 0.0178 | 0.0223 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0216 | 0.1427 | 0.1427 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0842 | 0.7968 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | < 8 ml/min.kg | Intrinsic clearance in human liver microsomes | ChEMBL. | No reference |
EC50 (binding) | = 153 nM | Activation of recombinant human glucokinase assessed as formation of glucose-6-phosphate by G6PDH/NADP coupled assay | LITERATURE. | No reference |
Inhibition (binding) | = 6 % | Inhibition of dofetilide binding to human ERG at 10 uM relative to control | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.