Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 8 | Starlite/ChEMBL | No references |
Homo sapiens | mitogen-activated protein kinase 10 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | c Jun NH2 terminal kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Echinococcus granulosus | c-Jun N-terminal kinases | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma japonicum | ko:K04440 c-Jun N-terminal kinase, putative | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma japonicum | IPR000164,Histone H3;IPR009072,Histone-fold,domain-containing | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Brugia malayi | Stress-activated protein kinase jnk-1 | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0558 | 1 | 1 |
Trypanosoma cruzi | Rab-like 5, small G protein | 0.0023 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.054 | 0.9668 | 0.9668 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | 0.054 | 0.9668 | 0.9668 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0558 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | Rab-like 5, small G protein | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | GTP binding protein rare7l, putative | 0.0023 | 0 | 0.5 |
Plasmodium falciparum | ras-related protein Rab-5A | 0.0023 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0023 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0 | 0.5 |
Plasmodium vivax | ras-related protein Rab-5A, putative | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | leucine rich repeat serine:threonine protein | 0.0544 | 0.9736 | 0.9736 |
Leishmania major | hypothetical protein, conserved | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | 0.054 | 0.9668 | 0.9668 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0558 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0558 | 1 | 1 |
Onchocerca volvulus | Mitochondrial Rho GTPase homolog | 0.0023 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 320 nM | Inhibition of JNK3 (unknown origin) using biotinylated ATF2 by HTRF method | ChEMBL. | No reference |
IC50 (binding) | = 590 nM | Inhibition of JNK2 (unknown origin) using biotinylated ATF2 by HTRF method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.