Detailed information for compound 185610

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 374.217 | Formula: C14H19IN2O2
  • H donors: 0 H acceptors: 2 LogP: 2.17 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(CCC[N+](C)(C)C)C(=O)c2c1cccc2.[I-]
  • InChi: 1S/C14H19N2O2.HI/c1-16(2,3)10-6-9-15-13(17)11-7-4-5-8-12(11)14(15)18;/h4-5,7-8H,6,9-10H2,1-3H3;1H/q+1;/p-1
  • InChiKey: HAHCPVAWTNLWNQ-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0175 0.0313 0.1612
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0148 0.0249 0.059
Echinococcus multilocularis neuropeptide s receptor 0.0148 0.0249 0.0249
Brugia malayi putative neuropeptide receptor NPR1 0.0148 0.0249 0.1284
Loa Loa (eye worm) integrin beta-2 0.0611 0.1353 0.6974
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Loa Loa (eye worm) hypothetical protein 0.0175 0.0313 0.1612
Loa Loa (eye worm) hypothetical protein 0.0252 0.0496 0.2557
Brugia malayi Serotonin receptor 0.0148 0.0249 0.1284
Loa Loa (eye worm) hypothetical protein 0.0294 0.0597 0.3079
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0131 0.0209 0.0209
Brugia malayi PAN domain containing protein 0.0175 0.0313 0.1612
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0148 0.0249 0.059
Onchocerca volvulus 0.0148 0.0249 0.0312
Loa Loa (eye worm) melatonin receptor type 1A 0.0148 0.0249 0.1284
Brugia malayi hypothetical protein 0.0131 0.0209 0.1077
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0115 0.0172 0.0884
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0163 0.0286 0.1473
Onchocerca volvulus 0.0507 0.1105 0.5216
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0858 0.194 0.4593
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Brugia malayi hypothetical protein 0.0131 0.0209 0.1077
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Loa Loa (eye worm) hypothetical protein 0.0175 0.0313 0.1612
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0186 0.034 0.034
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0294 0.0597 0.3079
Brugia malayi hypothetical protein 0.0148 0.0249 0.1284
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0294 0.0597 0.3079
Echinococcus multilocularis neuropeptide Y receptor 0.0148 0.0249 0.0249
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0148 0.0249 0.1284
Loa Loa (eye worm) hypothetical protein 0.0163 0.0286 0.1473
Onchocerca volvulus 0.0148 0.0249 0.0312
Schistosoma mansoni neurotransmitter gated ion channel 0.0163 0.0286 0.0676
Loa Loa (eye worm) hypothetical protein 0.0507 0.1105 0.5696
Onchocerca volvulus 0.0148 0.0249 0.0312
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0131 0.0209 0.0209
Schistosoma mansoni opsin-like receptor 0.0148 0.0249 0.059
Loa Loa (eye worm) ACC-1 protein 0.0294 0.0597 0.3079
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Echinococcus multilocularis neuropeptide Y receptor 0.0148 0.0249 0.0249
Echinococcus granulosus somatostatin receptor 0.0148 0.0249 0.0249
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0294 0.0597 0.0597
Echinococcus granulosus sex peptide receptor 0.0148 0.0249 0.0249
Entamoeba histolytica hypothetical protein 0.0163 0.0286 1
Loa Loa (eye worm) SRC-1 0.0186 0.034 0.1753
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0148 0.0249 0.0249
Loa Loa (eye worm) G-protein coupled receptor 0.0148 0.0249 0.1284
Brugia malayi hypothetical protein 0.0093 0.0118 0.061
Loa Loa (eye worm) hypothetical protein 0.0131 0.0209 0.1077
Brugia malayi PAN domain containing protein 0.0175 0.0313 0.1612
Echinococcus granulosus glycine receptor subunit alpha 1 0.0294 0.0597 0.0597
Schistosoma mansoni amine GPCR 0.0148 0.0249 0.059
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0294 0.0597 0.1414
Loa Loa (eye worm) TK protein kinase 0.0168 0.0297 0.153
Brugia malayi PAN domain containing protein 0.0175 0.0313 0.1612
Echinococcus multilocularis voltage dependent calcium channel 0.0115 0.0172 0.0172
Brugia malayi hypothetical protein 0.0131 0.0209 0.1077
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0294 0.0597 0.0597
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0148 0.0249 0.0249
Onchocerca volvulus 0.0175 0.0313 0.0677
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0294 0.0597 0.0597
Schistosoma mansoni neuropeptide f receptor 76f 0.0148 0.0249 0.059
Echinococcus granulosus tyrosine protein kinase Lyn 0.0186 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0131 0.0209 0.1077
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0148 0.0249 0.0249
Toxoplasma gondii PAN domain-containing protein 0.1873 0.4356 1
Schistosoma mansoni neuropeptide F-like receptor 0.0148 0.0249 0.059
Schistosoma mansoni tyrosine kinase 0.0186 0.034 0.0805
Onchocerca volvulus 0.0149 0.0252 0.033
Echinococcus granulosus neuropeptide Y receptor 0.0148 0.0249 0.0249
Onchocerca volvulus 0.0148 0.0249 0.0312
Loa Loa (eye worm) TK protein kinase 0.0149 0.0253 0.1302
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0148 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Brugia malayi Dopamine receptor protein 1 0.0148 0.0249 0.1284
Echinococcus granulosus g-protein coupled receptor 0.0148 0.0249 0.0249
Schistosoma mansoni cercarial elastase (S01 family) 0.0149 0.0252 0.0597
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0148 0.0249 0.1284
Loa Loa (eye worm) hypothetical protein 0.0175 0.0313 0.1612
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0148 0.0249 0.059
Brugia malayi Dopamine receptor 0.0148 0.0249 0.1284
Echinococcus granulosus nAChR subunit 0.0294 0.0597 0.0597
Brugia malayi hypothetical protein 0.0148 0.0249 0.1284
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0131 0.0209 0.0209
Onchocerca volvulus 0.0129 0.0205 0.0058
Loa Loa (eye worm) hypothetical protein 0.0294 0.0597 0.3079
Echinococcus granulosus rhodopsin orphan GPCR 0.0148 0.0249 0.0249
Schistosoma mansoni neuropeptide F-like receptor 0.0148 0.0249 0.059
Onchocerca volvulus 0.0294 0.0597 0.2308
Onchocerca volvulus 0.0163 0.0286 0.0522
Brugia malayi Melatonin receptor type 1A 0.0148 0.0249 0.1284
Echinococcus granulosus neuropeptides capa receptor 0.0148 0.0249 0.0249
Echinococcus granulosus g protein coupled receptor 0.0148 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Brugia malayi ORL1-like opioid receptor 0.0148 0.0249 0.1284
Echinococcus granulosus neuropeptide receptor 0.0148 0.0249 0.0249
Toxoplasma gondii kringle domain-containing protein 0.0252 0.0496 0.0453
Echinococcus multilocularis rhodopsin orphan GPCR 0.0148 0.0249 0.0249
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0904 0.2049 0.4852
Loa Loa (eye worm) hypothetical protein 0.0294 0.0597 0.3079
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0252 0.0496 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.0148 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0175 0.0313 0.1612
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0186 0.034 0.034
Echinococcus granulosus rhodopsin orphan GPCR 0.0148 0.0249 0.0249
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0131 0.0209 0.1077
Echinococcus multilocularis rhodopsin orphan GPCR 0.0148 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0046 0.0007 0.0035
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Schistosoma mansoni biogenic amine (5HT) receptor 0.0148 0.0249 0.059
Loa Loa (eye worm) hypothetical protein 0.0049 0.0014 0.0071
Loa Loa (eye worm) hypothetical protein 0.0131 0.0209 0.1077
Echinococcus multilocularis neuropeptide receptor A26 0.0148 0.0249 0.0249
Onchocerca volvulus 0.0148 0.0249 0.0312
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0294 0.0597 0.0597
Schistosoma mansoni myosin xvIII 0.0148 0.0249 0.059
Loa Loa (eye worm) TK/ROR protein kinase 0.0257 0.0508 0.2622
Brugia malayi Cation transporter family protein 0.0294 0.0597 0.3079
Onchocerca volvulus 0.0149 0.0252 0.033
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0148 0.0249 0.1284
Echinococcus multilocularis tyrosine protein kinase Blk 0.0168 0.0297 0.0297
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0149 0.0252 0.0597
Loa Loa (eye worm) hypothetical protein 0.0294 0.0597 0.3079
Schistosoma mansoni voltage-gated potassium channel 0.0503 0.1095 0.2593
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Loa Loa (eye worm) ACC-1 protein 0.0294 0.0597 0.3079
Loa Loa (eye worm) hypothetical protein 0.0163 0.0286 0.1473
Brugia malayi Cation transporter family protein 0.0294 0.0597 0.3079
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0294 0.0597 0.3079
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0186 0.034 0.034
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0148 0.0249 0.0249
Echinococcus multilocularis somatostatin receptor 0.0148 0.0249 0.0249
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0294 0.0597 0.3079
Brugia malayi Muscle positioning protein 4 0.0129 0.0205 0.1055
Loa Loa (eye worm) hypothetical protein 0.0046 0.0007 0.0035
Onchocerca volvulus 0.0148 0.0249 0.0312
Loa Loa (eye worm) hypothetical protein 0.0149 0.0252 0.13
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0294 0.0597 0.3079
Loa Loa (eye worm) hypothetical protein 0.0131 0.0209 0.1077
Mycobacterium ulcerans hypothetical protein 0.0149 0.0252 0.5
Loa Loa (eye worm) hypothetical protein 0.0294 0.0597 0.3079
Schistosoma mansoni biogenic amine (5HT) receptor 0.0148 0.0249 0.059
Schistosoma mansoni cercarial elastase (S01 family) 0.0149 0.0252 0.0597
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Loa Loa (eye worm) hypothetical protein 0.0175 0.0313 0.1612
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Loa Loa (eye worm) hypothetical protein 0.0125 0.0195 0.1003
Schistosoma mansoni biogenic amine receptor 0.0148 0.0249 0.059
Onchocerca volvulus Putative nachr subunit 0.0294 0.0597 0.2308
Echinococcus multilocularis orexin receptor type 2 0.0148 0.0249 0.0249
Echinococcus multilocularis integrin beta 2 0.0453 0.0975 0.0975
Brugia malayi Trypsin family protein 0.0149 0.0252 0.13
Loa Loa (eye worm) hypothetical protein 0.0163 0.0286 0.1473
Loa Loa (eye worm) PAN domain-containing protein 0.0175 0.0313 0.1612
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0131 0.0209 0.1077
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0186 0.034 0.034
Echinococcus granulosus tyrosine protein kinase Src42A 0.0186 0.034 0.034
Echinococcus granulosus biogenic amine 5HT receptor 0.0148 0.0249 0.0249
Echinococcus multilocularis rhodopsin orphan GPCR 0.0148 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0093 0.0118 0.061
Echinococcus granulosus 7tm_1 domain containing protein 0.0148 0.0249 0.0249
Brugia malayi PAN domain containing protein 0.0175 0.0313 0.1612
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0503 0.1095 0.1095
Brugia malayi G protein-coupled receptor 0.0148 0.0249 0.1284
Schistosoma mansoni cercarial elastase (S01 family) 0.0149 0.0252 0.0597
Brugia malayi protein-tyrosine kinase 0.0168 0.0297 0.153
Schistosoma mansoni adenoreceptor 0.0148 0.0249 0.059
Brugia malayi Trypsin family protein 0.0149 0.0252 0.13
Loa Loa (eye worm) hypothetical protein 0.0163 0.0286 0.1473
Echinococcus multilocularis sex peptide receptor 0.0148 0.0249 0.0249
Echinococcus multilocularis g-protein coupled receptor 0.0148 0.0249 0.0249
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0149 0.0252 0.0597
Loa Loa (eye worm) calcium channel 0.0115 0.0172 0.0884
Schistosoma mansoni hypothetical protein 0.0148 0.0249 0.059
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0294 0.0597 0.0597
Brugia malayi Serotonin receptor 0.0148 0.0249 0.1284
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0294 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Onchocerca volvulus 0.0131 0.0209 0.0082
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0148 0.0249 0.059
Schistosoma mansoni nAChR subunit 0.0294 0.0597 0.1414
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0294 0.0597 0.0597
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0148 0.0249 0.059
Onchocerca volvulus 0.0175 0.0313 0.0677
Schistosoma mansoni nAChR subunit 0.0294 0.0597 0.1414
Echinococcus granulosus rhodopsin orphan GPCR 0.0148 0.0249 0.0249
Brugia malayi SEA domain containing protein 0.0125 0.0195 0.1003
Onchocerca volvulus 0.0858 0.194 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Schistosoma mansoni integrin beta subunit 0.036 0.0754 0.1786
Loa Loa (eye worm) hypothetical protein 0.0376 0.0793 0.4089
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0163 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0163 0.0286 0.1473
Schistosoma mansoni nAChR subunit 0.0294 0.0597 0.1414
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0294 0.0597 0.0597
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0163 0.0286 0.1473
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0294 0.0597 0.3079
Echinococcus multilocularis transmembrane protease serine 3 0.0149 0.0252 0.0252
Echinococcus granulosus voltage dependent calcium channel 0.0115 0.0172 0.0172
Loa Loa (eye worm) LGC-31 protein 0.0294 0.0597 0.3079
Onchocerca volvulus 0.0148 0.0249 0.0312
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Echinococcus granulosus tyrosine protein kinase Fyn 0.0186 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Loa Loa (eye worm) hypothetical protein 0.0175 0.0313 0.1612
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0148 0.0249 0.059
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Echinococcus granulosus serotonin receptor 0.0148 0.0249 0.0249
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0115 0.0172 0.0172
Brugia malayi PAN domain containing protein 0.0175 0.0313 0.1612
Loa Loa (eye worm) hypothetical protein 0.0503 0.1095 0.5647
Brugia malayi G protein-coupled receptor F59B2.13 0.0148 0.0249 0.1284
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0294 0.0597 0.3079
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0148 0.0249 0.1284
Brugia malayi sulfakinin receptor protein 0.0148 0.0249 0.1284
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0294 0.0597 0.3079
Brugia malayi follicle stimulating hormone receptor 0.0148 0.0249 0.1284
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0115 0.0172 0.0406
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0148 0.0249 0.1284
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0115 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0129 0.0205 0.1055
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0131 0.0209 0.1077
Schistosoma mansoni cercarial elastase (S01 family) 0.0149 0.0252 0.0597
Loa Loa (eye worm) hypothetical protein 0.0131 0.0209 0.1077
Onchocerca volvulus 0.0175 0.0313 0.0677
Brugia malayi hypothetical protein 0.0131 0.0209 0.1077
Loa Loa (eye worm) hypothetical protein 0.0131 0.0209 0.1077
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Schistosoma mansoni amine GPCR 0.0148 0.0249 0.059
Echinococcus granulosus biogenic amine 5HT receptor 0.0148 0.0249 0.0249
Schistosoma mansoni biogenic amine receptor 0.0148 0.0249 0.059
Onchocerca volvulus 0.0175 0.0313 0.0677
Echinococcus multilocularis G protein coupled receptor 139 0.0296 0.0602 0.0602
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0294 0.0597 0.3079
Schistosoma mansoni alpha-1 adrenergic receptor 0.0148 0.0249 0.059
Echinococcus granulosus transmembrane protease serine 3 0.0149 0.0252 0.0252
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0294 0.0597 0.1414
Echinococcus granulosus dro:myosuppressin receptor 0.0148 0.0249 0.0249
Brugia malayi Trypsin-like protease protein 5 0.0149 0.0252 0.13
Onchocerca volvulus 0.0149 0.0252 0.033
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0116 0.0174 0.0896
Toxoplasma gondii PAN domain-containing protein 0.1873 0.4356 1
Brugia malayi hypothetical protein 0.0148 0.0249 0.1284
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0115 0.0172 0.0172
Schistosoma mansoni neuropeptide receptor 0.0148 0.0249 0.059
Brugia malayi larval opioid receptor 0.0148 0.0249 0.1284
Echinococcus granulosus enteropeptidase 0.0149 0.0252 0.0252
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0078 0.0082 0.5
Schistosoma mansoni biogenic amine receptor 0.0148 0.0249 0.059
Loa Loa (eye worm) hypothetical protein 0.0294 0.0597 0.3079
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0149 0.0252 0.0252
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0186 0.034 0.034
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0131 0.0209 0.0209
Echinococcus granulosus glycine receptor subunit beta 0.0294 0.0597 0.0597
Echinococcus multilocularis neuropeptide FF receptor 2 0.0148 0.0249 0.0249
Schistosoma mansoni tyrosine kinase 0.0186 0.034 0.0805
Onchocerca volvulus 0.0175 0.0313 0.0677
Leishmania major hypothetical protein, conserved 0.0252 0.0496 0.5
Echinococcus granulosus glycoprotein Antigen 5 0.0149 0.0252 0.0252
Schistosoma mansoni nAChR subunit 0.0294 0.0597 0.1414
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0168 0.0297 0.0297
Schistosoma mansoni nAChR subunit 0.0294 0.0597 0.1414
Schistosoma mansoni nAChR subunit 0.0294 0.0597 0.1414
Loa Loa (eye worm) hypothetical protein 0.0294 0.0597 0.3079
Brugia malayi Trypsin family protein 0.0149 0.0252 0.13
Brugia malayi hypothetical protein 0.0131 0.0209 0.1077
Echinococcus granulosus tyrosine kinase 0.0168 0.0297 0.0297
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0186 0.034 0.034
Echinococcus multilocularis tyrosine protein kinase HCK 0.0149 0.0253 0.0253
Brugia malayi GnHR receptor homolog 0.0148 0.0249 0.1284
Schistosoma mansoni nAChR subunit 0.0131 0.0209 0.0495
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0172 0.0308 0.0728
Echinococcus granulosus tyrosine protein kinase Src64B 0.0186 0.034 0.034
Onchocerca volvulus 0.0148 0.0249 0.0312
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0148 0.0249 0.059
Brugia malayi Cation transporter family protein 0.0507 0.1105 0.5696
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0149 0.0252 0.13
Echinococcus granulosus g protein coupled receptor 0.0148 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0163 0.0286 0.1473
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Schistosoma mansoni voltage-gated cation channel 0.0115 0.0172 0.0406
Loa Loa (eye worm) hypothetical protein 0.0294 0.0597 0.3079
Onchocerca volvulus Neuropeptide F receptor homolog 0.0148 0.0249 0.0312
Brugia malayi Protein kinase domain containing protein 0.0257 0.0508 0.2622
Schistosoma mansoni opsin-like receptor 0.0148 0.0249 0.059
Brugia malayi hypothetical protein 0.0148 0.0249 0.1284
Trypanosoma cruzi hypothetical protein, conserved 0.0252 0.0496 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0294 0.0597 0.1414
Loa Loa (eye worm) hypothetical protein 0.0131 0.0209 0.1077
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0148 0.0249 0.059
Echinococcus multilocularis potassium voltage gated channel protein 0.0503 0.1095 0.1095
Loa Loa (eye worm) hypothetical protein 0.0131 0.0209 0.1077
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0186 0.034 0.034
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0294 0.0597 0.3079
Onchocerca volvulus 0.0294 0.0597 0.2308
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0014 0.0071
Loa Loa (eye worm) hypothetical protein 0.0294 0.0597 0.3079
Schistosoma mansoni acetylcholine receptor-related 0.0131 0.0209 0.0495
Schistosoma mansoni neuropeptide receptor 0.0296 0.0602 0.1426
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0294 0.0597 0.0597
Loa Loa (eye worm) TYRA-2 protein 0.0148 0.0249 0.1284
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0131 0.0209 0.1077
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0148 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0294 0.0597 0.3079
Schistosoma mansoni hypothetical protein 0.0252 0.0496 0.1175
Brugia malayi RE15519p 0.0148 0.0249 0.1284
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0294 0.0597 0.3079
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0294 0.0597 0.1414
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Echinococcus granulosus neuropeptide Y receptor 0.0148 0.0249 0.0249
Brugia malayi hypothetical protein 0.0148 0.0249 0.1284
Loa Loa (eye worm) hypothetical protein 0.0149 0.0252 0.13
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0148 0.0249 0.0249
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0148 0.0249 0.059
Onchocerca volvulus 0.0148 0.0249 0.0312
Onchocerca volvulus 0.0148 0.0249 0.0312
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0163 0.0286 0.0676
Schistosoma mansoni amine GPCR 0.0148 0.0249 0.059
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Schistosoma mansoni amine GPCR 0.0148 0.0249 0.059
Brugia malayi Dopamine receptor protein 2 0.0148 0.0249 0.1284
Schistosoma mansoni cercarial elastase (S01 family) 0.0149 0.0252 0.0597
Echinococcus granulosus rhodopsin orphan GPCR 0.0148 0.0249 0.0249
Echinococcus granulosus neuropeptide s receptor 0.0148 0.0249 0.0249
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0148 0.0249 0.059
Brugia malayi Integrin beta pat-3 precursor 0.0611 0.1353 0.6974
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Echinococcus granulosus potassium voltage gated channel protein 0.0503 0.1095 0.1095
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0148 0.0249 0.0249
Loa Loa (eye worm) PAN domain-containing protein 0.0175 0.0313 0.1612
Schistosoma mansoni acetylcholine receptor subunit beta 0.0131 0.0209 0.0495
Onchocerca volvulus 0.0149 0.0252 0.033
Onchocerca volvulus 0.0149 0.0252 0.033
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0148 0.0249 0.0249
Echinococcus multilocularis rhodopsin orphan GPCR 0.0148 0.0249 0.0249
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0163 0.0286 0.1473
Echinococcus multilocularis tyrosine protein kinase Srms 0.0168 0.0297 0.0297
Onchocerca volvulus 0.0148 0.0249 0.0312
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Onchocerca volvulus 0.0163 0.0286 0.0522
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Loa Loa (eye worm) hypothetical protein 0.0131 0.0209 0.1077
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0148 0.0249 0.059
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0148 0.0249 0.1284
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Echinococcus granulosus g protein coupled receptor 0.0148 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0858 0.194 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0148 0.0249 0.0249
Brugia malayi PAN domain containing protein 0.0175 0.0313 0.1612
Echinococcus multilocularis neuropeptides capa receptor 0.0148 0.0249 0.0249
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0131 0.0209 0.1077
Onchocerca volvulus 0.0148 0.0249 0.0312
Onchocerca volvulus 0.0148 0.0249 0.0312
Loa Loa (eye worm) hypothetical protein 0.0294 0.0597 0.3079
Schistosoma mansoni hypothetical protein 0.0149 0.0252 0.0597
Echinococcus granulosus tissue type plasminogen activator 0.0252 0.0496 0.0496
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0148 0.0249 0.059
Echinococcus granulosus allatostatin A receptor 0.0148 0.0249 0.0249
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0294 0.0597 0.0597
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0294 0.0597 0.0597
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0115 0.0172 0.0406
Onchocerca volvulus 0.0709 0.1585 0.7965
Onchocerca volvulus 0.0252 0.0496 0.1727
Brugia malayi hypothetical protein 0.0148 0.0249 0.1284
Brugia malayi neuropeptide F receptor 0.0148 0.0249 0.1284
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.006 0.0039 0.0039
Echinococcus granulosus tachykinin peptides receptor 99D 0.0148 0.0249 0.0249
Echinococcus granulosus hypothetical protein 0.0148 0.0249 0.0249
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0148 0.0249 0.059
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0163 0.0286 0.0676
Echinococcus multilocularis rhodopsin orphan GPCR 0.0148 0.0249 0.0249
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0149 0.0252 0.0597
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0148 0.0249 0.1284
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0294 0.0597 0.3079
Echinococcus granulosus glycine receptor subunit alpha 1 0.0294 0.0597 0.0597
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0115 0.0172 0.0172
Brugia malayi excitatory GABA receptor EXP-1A 0.0294 0.0597 0.3079
Brugia malayi hypothetical protein 0.0148 0.0249 0.1284
Echinococcus multilocularis neuropeptides capa receptor 0.0148 0.0249 0.0249
Schistosoma mansoni growth hormone secretagogue receptor 0.0148 0.0249 0.059
Loa Loa (eye worm) hypothetical protein 0.0294 0.0597 0.3079
Echinococcus multilocularis fmrfamide receptor 0.0148 0.0249 0.0249
Echinococcus multilocularis rhodopsin orphan GPCR 0.0148 0.0249 0.0249
Echinococcus multilocularis serotonin receptor 0.0148 0.0249 0.0249
Echinococcus granulosus rhodopsin orphan GPCR 0.0148 0.0249 0.0249
Echinococcus multilocularis tissue type plasminogen activator 0.0252 0.0496 0.0496
Schistosoma mansoni neuropeptide receptor 0.0148 0.0249 0.059
Schistosoma mansoni hypothetical protein 0.0148 0.0249 0.059
Onchocerca volvulus 0.0507 0.1105 0.5216
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Schistosoma mansoni cercarial elastase (S01 family) 0.0149 0.0252 0.0597
Brugia malayi G-protein coupled receptor 0.0148 0.0249 0.1284
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0186 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0186 0.034 0.034
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0294 0.0597 0.3079
Brugia malayi PAN domain containing protein 0.0175 0.0313 0.1612
Brugia malayi AKH receptor 0.0148 0.0249 0.1284
Echinococcus granulosus glycine receptor subunit beta 0.0294 0.0597 0.0597
Schistosoma mansoni voltage-gated potassium channel 0.0503 0.1095 0.2593
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0294 0.0597 0.3079
Loa Loa (eye worm) hypothetical protein 0.0294 0.0597 0.3079
Echinococcus granulosus tyrosine protein kinase Fyn 0.0186 0.034 0.034
Brugia malayi hypothetical protein 0.0148 0.0249 0.1284
Loa Loa (eye worm) hypothetical protein 0.0507 0.1105 0.5696
Loa Loa (eye worm) hypothetical protein 0.0163 0.0286 0.1473
Onchocerca volvulus 0.0175 0.0313 0.0677
Schistosoma mansoni histamine h1 receptor 0.0148 0.0249 0.059
Echinococcus granulosus neuropeptide FF receptor 2 0.0148 0.0249 0.0249
Schistosoma mansoni cercarial elastase (S01 family) 0.0149 0.0252 0.0597
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0294 0.0597 0.3079
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0294 0.0597 0.0597
Onchocerca volvulus 0.0148 0.0249 0.0312
Loa Loa (eye worm) hypothetical protein 0.0149 0.0252 0.13
Echinococcus granulosus nAChR subunit 0.0163 0.0286 0.0286
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0148 0.0249 0.1284
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0507 0.1105 0.2616
Plasmodium falciparum cysteine repeat modular protein 1 0.0252 0.0496 0.5
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Loa Loa (eye worm) hypothetical protein 0.0131 0.0209 0.1077
Onchocerca volvulus 0.0131 0.0209 0.0082
Onchocerca volvulus 0.0175 0.0313 0.0677
Schistosoma mansoni cercarial elastase (S01 family) 0.0149 0.0252 0.0597
Loa Loa (eye worm) hypothetical protein 0.0294 0.0597 0.3079
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0294 0.0597 0.0597
Loa Loa (eye worm) trypsin family protein 0.0149 0.0252 0.13
Echinococcus multilocularis rhodopsin orphan GPCR 0.0148 0.0249 0.0249
Echinococcus multilocularis neuropeptide receptor 0.0296 0.0602 0.0602
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0294 0.0597 0.0597
Echinococcus multilocularis neuropeptide receptor 0.0148 0.0249 0.0249
Echinococcus multilocularis rhodopsin orphan GPCR 0.0148 0.0249 0.0249
Echinococcus multilocularis Mastin 0.0149 0.0252 0.0252
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0149 0.0252 0.0252
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0148 0.0249 0.059
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0149 0.0252 0.0252
Echinococcus multilocularis nAChR subunit 0.0294 0.0597 0.0597
Echinococcus granulosus tyrosine protein kinase Src42A 0.0163 0.0284 0.0284
Onchocerca volvulus 0.0175 0.0313 0.0677
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Echinococcus multilocularis g protein coupled receptor 0.0148 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Echinococcus granulosus glycine receptor subunit alpha 1 0.0294 0.0597 0.0597
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0148 0.0249 0.059
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0149 0.0252 0.0597
Schistosoma mansoni hypothetical protein 0.0148 0.0249 0.059
Loa Loa (eye worm) hypothetical protein 0.0131 0.0209 0.1077
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0294 0.0597 0.3079
Schistosoma mansoni serine-type protease inhibitor 0.1817 0.4223 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0148 0.0249 0.0249
Schistosoma mansoni hypothetical protein 0.0125 0.0195 0.0461
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0294 0.0597 0.0597
Loa Loa (eye worm) DOMON domain-containing protein 0.0125 0.0195 0.1003
Loa Loa (eye worm) hypothetical protein 0.0294 0.0597 0.3079
Loa Loa (eye worm) hypothetical protein 0.0294 0.0597 0.3079
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Brugia malayi PAN domain containing protein 0.0175 0.0313 0.1612
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0148 0.0249 0.0249
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0148 0.0249 0.0249
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0148 0.0249 0.059
Echinococcus granulosus integrin beta 2 0.0453 0.0975 0.0975
Brugia malayi neuropeptide F receptor 0.0148 0.0249 0.1284
Onchocerca volvulus 0.0175 0.0313 0.0677
Brugia malayi Tachykinin-like peptides receptor 99D 0.0148 0.0249 0.1284
Loa Loa (eye worm) neuropeptide F receptor 0.0148 0.0249 0.1284
Echinococcus granulosus neuropeptides capa receptor 0.0148 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0131 0.0209 0.1077
Echinococcus multilocularis glycine receptor subunit beta 0.0294 0.0597 0.0597
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0148 0.0249 0.059
Onchocerca volvulus 0.0294 0.0597 0.2308
Echinococcus granulosus tyrosine protein kinase HCK 0.0149 0.0253 0.0253
Brugia malayi Trypsin family protein 0.0858 0.194 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0148 0.0249 0.0249
Echinococcus granulosus 7TM GPCR rhodopsin 0.0148 0.0249 0.0249
Onchocerca volvulus 0.0175 0.0313 0.0677
Onchocerca volvulus 0.0175 0.0313 0.0677
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0131 0.0209 0.1077
Brugia malayi putative neuropeptide receptor 0.0148 0.0249 0.1284
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0131 0.0209 0.1077
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0148 0.0249 0.1284
Loa Loa (eye worm) hypothetical protein 0.0149 0.0252 0.13
Onchocerca volvulus 0.0148 0.0249 0.0312
Echinococcus multilocularis g protein coupled receptor 0.0148 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0131 0.0209 0.1077
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0168 0.0297 0.0297
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0148 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Loa Loa (eye worm) G-protein coupled receptor 0.0148 0.0249 0.1284
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0294 0.0597 0.0597
Echinococcus multilocularis g protein coupled receptor 0.0148 0.0249 0.0249
Onchocerca volvulus 0.0148 0.0249 0.0312
Echinococcus granulosus rhodopsin orphan GPCR 0.0148 0.0249 0.0249
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0148 0.0249 0.059
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0148 0.0249 0.0249
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0481 0.1043 0.1043
Echinococcus multilocularis glycine receptor subunit beta 0.0294 0.0597 0.0597
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0115 0.0172 0.0172
Loa Loa (eye worm) acetylcholine receptor protein 0.0131 0.0209 0.1077
Schistosoma mansoni opsin-like receptor 0.0148 0.0249 0.059
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0294 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.0294 0.0597 0.3079
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0294 0.0597 0.3079
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0163 0.0286 0.1473
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0148 0.0249 0.059
Loa Loa (eye worm) PAN domain-containing protein 0.0175 0.0313 0.1612
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0294 0.0597 0.3079
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0148 0.0249 0.0312
Schistosoma mansoni cercarial elastase (S01 family) 0.0149 0.0252 0.0597
Schistosoma mansoni nAChR subunit 0.0294 0.0597 0.1414
Echinococcus granulosus neuropeptide receptor A26 0.0148 0.0249 0.0249
Loa Loa (eye worm) PAN domain-containing protein 0.0175 0.0313 0.1612
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0014 0.0071
Echinococcus granulosus peptide allatostatin:somatostatin 0.0148 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0131 0.0209 0.1077
Loa Loa (eye worm) hypothetical protein 0.0115 0.0172 0.0884
Schistosoma mansoni cercarial elastase (S01 family) 0.0149 0.0252 0.0597
Echinococcus granulosus orexin receptor type 2 0.0148 0.0249 0.0249
Echinococcus multilocularis allatostatin A receptor 0.0148 0.0249 0.0249
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0148 0.0249 0.059
Schistosoma mansoni hypothetical protein 0.0149 0.0252 0.0597
Echinococcus multilocularis voltage dependent calcium channel 0.0115 0.0172 0.0172
Onchocerca volvulus 0.0148 0.0249 0.0312
Echinococcus granulosus rhodopsin orphan GPCR 0.0148 0.0249 0.0249
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0148 0.0249 0.0249
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0186 0.034 0.034
Echinococcus granulosus tyrosine protein kinase Blk 0.0168 0.0297 0.0297
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0186 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0163 0.0286 0.1473
Brugia malayi hypothetical protein 0.0149 0.0252 0.13
Schistosoma mansoni nAChR subunit 0.0131 0.0209 0.0495
Echinococcus multilocularis sodium channel protein 0.006 0.0039 0.0039
Echinococcus multilocularis fmrfamide receptor 0.0148 0.0249 0.0249
Echinococcus granulosus fmrfamide receptor 0.0148 0.0249 0.0249
Brugia malayi CUB domain containing protein 0.0046 0.0007 0.0035
Echinococcus granulosus tm gpcr rhodopsin 0.0148 0.0249 0.0249
Brugia malayi hypothetical protein 0.0148 0.0249 0.1284
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0294 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Loa Loa (eye worm) hypothetical protein 0.0858 0.194 1
Echinococcus multilocularis serotonin receptor 0.0148 0.0249 0.0249
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0014 0.0071
Schistosoma mansoni cercarial elastase (S01 family) 0.0149 0.0252 0.0597
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0148 0.0249 0.0249
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0148 0.0249 0.0249
Echinococcus granulosus tm gpcr rhodopsin 0.0148 0.0249 0.0249
Schistosoma mansoni hypothetical protein 0.0148 0.0249 0.059
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0148 0.0249 0.1284
Echinococcus granulosus tyrosine protein kinase Fyn 0.0186 0.034 0.034
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0503 0.1095 0.5647
Echinococcus granulosus alpha 1A adrenergic receptor 0.0148 0.0249 0.0249
Schistosoma mansoni amine GPCR 0.0148 0.0249 0.059
Echinococcus multilocularis enteropeptidase 0.0149 0.0252 0.0252
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0294 0.0597 0.3079
Schistosoma mansoni neurotransmitter gated ion channel 0.0131 0.0209 0.0495
Brugia malayi PAN domain containing protein 0.0175 0.0313 0.1612
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Schistosoma mansoni serine-type protease inhibitor 0.1817 0.4223 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0131 0.0209 0.0209
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0294 0.0597 0.3079
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Brugia malayi Kringle domain containing protein 0.0252 0.0496 0.2557
Loa Loa (eye worm) PAN domain-containing protein 0.0175 0.0313 0.1612
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0507 0.1105 0.2616
Brugia malayi PAN domain containing protein 0.0175 0.0313 0.1612
Brugia malayi Kelch motif family protein 0.0116 0.0174 0.0896
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0131 0.0209 0.1077
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0294 0.0597 0.3079
Onchocerca volvulus 0.0131 0.0209 0.0082
Loa Loa (eye worm) GABA receptor subunit 0.0163 0.0286 0.1473
Schistosoma mansoni neuropeptide receptor 0.0148 0.0249 0.059
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0149 0.0252 0.0597
Brugia malayi hypothetical protein 0.0148 0.0249 0.1284
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0294 0.0597 0.3079
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0148 0.0249 0.0249
Loa Loa (eye worm) neuropeptide F receptor 0.0148 0.0249 0.1284
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Echinococcus multilocularis glycoprotein Antigen 5 0.0149 0.0252 0.0252
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.4244 1 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0249 0.1284
Echinococcus multilocularis nAChR subunit 0.0163 0.0286 0.0286
Echinococcus granulosus neuropeptide receptor 0.0296 0.0602 0.0602
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0115 0.0172 0.0172
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0148 0.0249 0.059
Brugia malayi G-protein coupled receptor 0.0148 0.0249 0.1284
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0148 0.0249 0.059
Loa Loa (eye worm) hypothetical protein 0.0131 0.0209 0.1077
Onchocerca volvulus 0.0507 0.1105 0.5216
Brugia malayi SRC-1 0.0186 0.034 0.1753
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0115 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0149 0.0252 0.13
Echinococcus granulosus Mastin 0.0149 0.0252 0.0252
Echinococcus granulosus G protein coupled receptor 139 0.0148 0.0249 0.0249
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0149 0.0252 0.0252
Schistosoma mansoni neurotransmitter gated ion channel 0.0131 0.0209 0.0495

Activities

Activity type Activity value Assay description Source Reference
Emax,diss (binding) = 25 % Dissociation constant of the compound towards Muscarinic acetylcholine receptor M2 ChEMBL. 15163212
Emax,diss (binding) = 25 % Dissociation constant of the compound towards Muscarinic acetylcholine receptor M2 ChEMBL. 15163212
Emax,diss (binding) = 100 % Emax diassociation of the compound towards Muscarinic acetylcholine receptor M2 ChEMBL. 15163212
Emax,diss (binding) = 100 % Emax diassociation of the compound towards Muscarinic acetylcholine receptor M2 ChEMBL. 15163212
Palpha (binding) < -2 Palpha of the compound towards Muscarinic acetylcholine receptor M2 in guinea pig using [3H]-AF-DX 384 as a radioligand ChEMBL. 15163212
Palpha (binding) = -1.21 Palpha of the compound towards Muscarinic acetylcholine receptor M2 in guinea pig using [3H]-NMS as a radioligand ChEMBL. 15163212
pEC0.5,diss (binding) = 3 Half-maximally reduction of the compound towards muscarinic 2 receptor in guinea pig using [3H]-AF-DX 384 as a radioligand ChEMBL. 15163212
pEC0.5,diss (binding) = 3.21 Half-maximal reduction of the compound towards Muscarinic acetylcholine receptor M2 ChEMBL. 15163212
pKA (binding) = 3.95 Binding affinity of the compound towards Muscarinic acetylcholine receptor M2 in guinea pig using [3H]-NMS as a radioligand ChEMBL. 15163212
pKA (binding) = 4.51 Binding affinity of the compound towards Muscarinic acetylcholine receptor M2 in guinea pig using [3H]-AF-DX 384 as a radioligand ChEMBL. 15163212

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.