Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1608 | 0.1608 |
Leishmania major | histone deacetylase, putative | 0.0029 | 0.0228 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1608 | 0.1608 |
Echinococcus granulosus | histone deacetylase 6 | 0.0029 | 0.0228 | 0.0228 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0153 | 0.1608 | 0.1608 |
Onchocerca volvulus | 0.0153 | 0.1608 | 1 | |
Entamoeba histolytica | histone deacetylase, putative | 0.0009 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0904 | 1 | 1 |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.0274 | 0.2957 | 0.2957 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.1608 | 0.1608 |
Giardia lamblia | Histone deacetylase | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0153 | 0.1608 | 0.1608 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0029 | 0.0228 | 0.0228 |
Echinococcus granulosus | neuroligin | 0.0153 | 0.1608 | 0.1608 |
Echinococcus granulosus | acetylcholinesterase | 0.0904 | 1 | 1 |
Plasmodium falciparum | histone deacetylase, putative | 0.0029 | 0.0228 | 1 |
Leishmania major | histone deacetylase, putative | 0.0029 | 0.0228 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0153 | 0.1608 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0153 | 0.1608 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0029 | 0.0228 | 0.0228 |
Loa Loa (eye worm) | histone deacetylase | 0.0029 | 0.0228 | 0.0228 |
Onchocerca volvulus | 0.0153 | 0.1608 | 1 | |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0153 | 0.1608 | 0.1608 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0029 | 0.0228 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0153 | 0.1608 | 0.1608 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0029 | 0.0228 | 0.0228 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0029 | 0.0228 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0054 | 0.0504 | 0.0504 |
Echinococcus granulosus | histone deacetylase | 0.0029 | 0.0228 | 0.0228 |
Brugia malayi | hypothetical protein | 0.0153 | 0.1608 | 0.1608 |
Brugia malayi | Carboxylesterase family protein | 0.0904 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0153 | 0.1608 | 0.1608 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1608 | 0.1608 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0029 | 0.0228 | 1 |
Plasmodium falciparum | histone deacetylase 2 | 0.0029 | 0.0228 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0904 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0029 | 0.0228 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0153 | 0.1608 | 0.1608 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.1608 | 0.1608 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0153 | 0.1608 | 0.1608 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0054 | 0.0504 | 0.0504 |
Schistosoma mansoni | gliotactin | 0.0153 | 0.1608 | 0.1608 |
Echinococcus granulosus | carboxylesterase 5A | 0.0904 | 1 | 1 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0274 | 0.2957 | 0.2957 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1608 | 0.1608 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.2957 | 0.2957 |
Echinococcus multilocularis | acetylcholinesterase | 0.0904 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0504 | 0.0504 |
Echinococcus multilocularis | acetylcholinesterase | 0.0904 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0153 | 0.1608 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0904 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0029 | 0.0228 | 0.0228 |
Trypanosoma brucei | histone deacetylase, putative | 0.0029 | 0.0228 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0029 | 0.0228 | 0.0228 |
Echinococcus granulosus | acetylcholinesterase | 0.0904 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 7 | 0.0029 | 0.0228 | 0.0228 |
Brugia malayi | amidase | 0.0054 | 0.0504 | 0.0504 |
Onchocerca volvulus | 0.0153 | 0.1608 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1608 | 0.1608 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0034 | 0.0278 | 0.0278 |
Trypanosoma brucei | histone deacetylase 3 | 0.0029 | 0.0228 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.013 | 0.013 |
Echinococcus multilocularis | histone deacetylase | 0.0029 | 0.0228 | 0.0228 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.2957 | 0.2957 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0153 | 0.1608 | 0.1608 |
Trypanosoma brucei | histone deacetylase 4 | 0.0029 | 0.0228 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.1608 | 0.1608 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.1608 | 0.1608 |
Brugia malayi | Histone deacetylase family protein | 0.0029 | 0.0228 | 0.0228 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.018 | 0.018 |
Plasmodium vivax | histone deacetylase, putative | 0.0029 | 0.0228 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1608 | 0.1608 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1608 | 0.1608 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0904 | 1 | 1 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0075 | 0.0737 | 0.0737 |
Onchocerca volvulus | 0.0153 | 0.1608 | 1 | |
Trypanosoma cruzi | histone deacetylase, putative | 0.0029 | 0.0228 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0153 | 0.1608 | 0.1608 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0153 | 0.1608 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0153 | 0.1608 | 0.1608 |
Echinococcus multilocularis | neuroligin | 0.0153 | 0.1608 | 0.1608 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0034 | 0.0278 | 0.0278 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0153 | 0.1608 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0029 | 0.0228 | 0.0228 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0054 | 0.0504 | 0.0504 |
Schistosoma mansoni | acetylcholinesterase | 0.0153 | 0.1608 | 0.1608 |
Onchocerca volvulus | 0.0153 | 0.1608 | 1 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0904 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0034 | 0.0278 | 0.0278 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0153 | 0.1608 | 0.1608 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0153 | 0.1608 | 1 |
Schistosoma mansoni | amidase | 0.0054 | 0.0504 | 0.0504 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.0411 | 0.4496 | 0.4496 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0153 | 0.1608 | 0.1608 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0153 | 0.1608 | 0.1608 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0029 | 0.0228 | 0.0228 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0054 | 0.0504 | 0.0504 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0054 | 0.0504 | 0.0504 |
Loa Loa (eye worm) | carboxylesterase | 0.0904 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0029 | 0.0228 | 0.0228 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
BP decrease (functional) | = 84 mmHg | Antihypertensive activity in spontaneously hypertensive rats(SHR) at 50 mg/kg peroral dose after 1 h, expressed as decrease in systolic blood pressure | ChEMBL. | 6115059 |
BP decrease (functional) | = 91 mmHg | Antihypertensive activity in spontaneously hypertensive rats(SHR) at 50 mg/kg peroral dose after 4 h, expressed as decrease in systolic blood pressure | ChEMBL. | 6115059 |
DR10 (functional) | = 3.61 mg kg-1 | In vivo sympatholytic activity (isoproterenol-induced vasodepression) at beta 2-adrenergic receptor in anesthetized dog, iv | ChEMBL. | 6115059 |
DR10 (functional) | = 5.44 mg kg-1 | In vivo sympatholytic activity (phenylphrine-induced vasopressor response) at alpha-adrenergic receptor in anesthetized dog, iv | ChEMBL. | 6115059 |
DR10 (functional) | = 8.63 mg kg-1 | In vivo sympatholytic activity (isoproterenol-induced chronotropy) at beta 1-adrenergic receptor in anesthetized dog, iv | ChEMBL. | 6115059 |
pA2 (binding) | = 5.9 | In vitro blocking activity against alpha adrenergic receptor, isolated from rabbit aortic strip | ChEMBL. | 6115059 |
pA2 (functional) | = 6.42 | spasmolytic activity in isolated guinea pig ileum preparation;- log KB; (Bacl2) | ChEMBL. | 6115059 |
pA2 (binding) | = 6.69 | In vitro blocking activity against beta adrenergic receptor, isolated from guinea pig atria | ChEMBL. | 6115059 |
Ratio (binding) | = 6.2 | Ratio of pA2 for beta-adrenergic receptor to that of alpha-adrenergic receptor | ChEMBL. | 6115059 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.