Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | 0.0153 | 0.1011 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0424 | 0.3226 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0153 | 0.1011 | 0.3133 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0153 | 0.1011 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0153 | 0.1011 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0153 | 0.1011 | 1 |
Onchocerca volvulus | 0.0452 | 0.3461 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1246 | 0.36 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.11 | 0.8754 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0181 | 0.1246 | 0.36 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1011 | 0.292 |
Brugia malayi | SWIRM domain containing protein | 0.0452 | 0.3461 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0153 | 0.1011 | 0.5 |
Leishmania major | UDP-galactopyranose mutase | 0.0153 | 0.1011 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0424 | 0.3226 | 0.9321 |
Schistosoma mansoni | amine oxidase | 0.0153 | 0.1011 | 0.3133 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.0167 | 0.1128 | 0.3259 |
Loa Loa (eye worm) | hypothetical protein | 0.0452 | 0.3461 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0153 | 0.1011 | 0.3133 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0153 | 0.1011 | 0.5 |
Echinococcus multilocularis | 0.0153 | 0.1011 | 0.3133 | |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1011 | 0.292 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0153 | 0.1011 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0153 | 0.1011 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.1128 | 0.3259 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0153 | 0.1011 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0424 | 0.3226 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1253 | 1 | 1 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0424 | 0.3226 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0153 | 0.1011 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0153 | 0.1011 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0153 | 0.1011 | 0.3133 |
Plasmodium vivax | hypothetical protein, conserved | 0.0153 | 0.1011 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0153 | 0.1011 | 0.3133 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.1168 | 0.3375 |
Brugia malayi | hypothetical protein | 0.0153 | 0.1011 | 0.292 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0153 | 0.1011 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0424 | 0.3226 | 0.9321 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED25 (functional) | NA 0 mg kg-1 | 25% increase in left ventricular contractility (dP/dtmax) on iv administration in anesthetized rat; Not active at 3 mg/kg | ChEMBL. | 2153209 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.