Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0415 | 0.0749 | 0.0749 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0254 | 0.0298 | 0.0353 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1195 | 0.2924 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0495 | 0.0972 | 0.1027 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0231 | 0.0236 | 0.0044 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0033 | 0.0033 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0495 | 0.0972 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0033 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0415 | 0.0749 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0033 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0495 | 0.0972 | 1 |
Onchocerca volvulus | 0.02 | 0.0149 | 0.5 | |
Echinococcus multilocularis | dihydrofolate reductase | 0.0415 | 0.0749 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1908 | 0.4911 | 0.4911 |
Brugia malayi | dihydrofolate reductase family protein | 0.0415 | 0.0749 | 0.0749 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0495 | 0.0972 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0415 | 0.0749 | 0.7701 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.3732 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.3732 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0415 | 0.0749 | 0.2578 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0415 | 0.0749 | 0.6965 |
Brugia malayi | Dihydrofolate reductase | 0.0415 | 0.0749 | 0.0749 |
Onchocerca volvulus | Putative sulfate transporter | 0.02 | 0.0149 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1195 | 0.2924 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.3732 | 1 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1195 | 0.2924 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.3732 | 1 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0495 | 0.0972 | 0.0972 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0473 | 0.091 | 0.3374 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0954 | 0.2251 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0415 | 0.0749 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0159 | 0.0033 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.