Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | carbonic anhydrase | 0.0293 | 0.1444 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | replicative DNA helicase | 0.0752 | 1 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0293 | 0.1444 | 0.1903 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.1444 | 0.1903 |
Schistosoma mansoni | Replicative DNA helicase | 0.0752 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0623 | 0.7589 | 0.7182 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.1444 | 0.1903 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0623 | 0.7589 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0623 | 0.7589 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0293 | 0.1444 | 0.5 |
Mycobacterium ulcerans | replicative DNA helicase DnaB | 0.0752 | 1 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0623 | 0.7589 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0623 | 0.7589 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0623 | 0.7589 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0623 | 0.7589 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0623 | 0.7589 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0623 | 0.7589 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0623 | 0.7589 | 0.7182 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0623 | 0.7589 | 1 |
Mycobacterium leprae | PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase | 0.0752 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.1444 | 0.1903 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0623 | 0.7589 | 1 |
Treponema pallidum | replicative DNA helicase (dnaB) | 0.0752 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.0752 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.