TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 517.902 | Formula: C32H59NO2Si
H donors: 2 H acceptors: 1 LogP: 8.63 Rotable bonds: 5
Rule of 5 violations (Lipinski): 2
SMILES: C[C@]12CC[C@@H](CC1CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2C(C1CCCNC1)(O)C)C)O[Si](C(C)(C)C)(C)C
InChi: 1S/C32H59NO2Si/c1-29(2,3)36(7,8)35-24-15-17-30(4)22(20-24)11-12-25-26-13-14-28(31(26,5)18-16-27(25)30)32(6,34)23-10-9-19-33-21-23/h22-28,33-34H,9-21H2,1-8H3/t22?,23?,24-,25-,26-,27-,28-,30-,31-,32?/m0/s1
InChiKey: CCSNJCXSNTXCPB-IEHYMPNPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Arabidopsis thaliana	cycloartenol-c-24-methyltransferase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	SAM:delta 24-methyltransferase involved in ergosterol biosynthesis	Get druggable targets OG5_129172	All targets in OG5_129172
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129172	All targets in OG5_129172
Trypanosoma brucei	sterol 24-c-methyltransferase, putative	Get druggable targets OG5_129172	All targets in OG5_129172
Leishmania major	sterol 24-c-methyltransferase, putative	Get druggable targets OG5_129172	All targets in OG5_129172
Trypanosoma cruzi	sterol 24-c-methyltransferase, putative	Get druggable targets OG5_129172	All targets in OG5_129172
Trypanosoma brucei	sterol 24-c-methyltransferase, putative	Get druggable targets OG5_129172	All targets in OG5_129172
Trypanosoma brucei gambiense	sterol 24-c-methyltransferase, putative	Get druggable targets OG5_129172	All targets in OG5_129172
Brugia malayi	S-adenosyl-methionine cycloartenol-C24-methyltransferase	Get druggable targets OG5_129172	All targets in OG5_129172
Leishmania mexicana	sterol 24-c-methyltransferase, putative	Get druggable targets OG5_129172	All targets in OG5_129172
Leishmania infantum	sterol 24-c-methyltransferase, putative	Get druggable targets OG5_129172	All targets in OG5_129172
Candida albicans	SAM:delta 24-methyltransferase involved in ergosterol biosynthesis	Get druggable targets OG5_129172	All targets in OG5_129172
Leishmania donovani	sterol 24-c-methyltransferase, putative	Get druggable targets OG5_129172	All targets in OG5_129172
Leishmania mexicana	sterol 24-c-methyltransferase, putative	Get druggable targets OG5_129172	All targets in OG5_129172
Trypanosoma brucei	Sterol methyltransferase, putative	Get druggable targets OG5_129172	All targets in OG5_129172
Leishmania major	sterol 24-c-methyltransferase, putative	Get druggable targets OG5_129172	All targets in OG5_129172
Trypanosoma cruzi	sterol 24-c-methyltransferase, putative	Get druggable targets OG5_129172	All targets in OG5_129172
Leishmania braziliensis	sterol 24-c-methyltransferase, putative	Get druggable targets OG5_129172	All targets in OG5_129172
Leishmania infantum	sterol 24-c-methyltransferase, putative	Get druggable targets OG5_129172	All targets in OG5_129172
Trypanosoma cruzi	sterol 24-c-methyltransferase, putative	Get druggable targets OG5_129172	All targets in OG5_129172

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	sterol 24-c-methyltransferase, putative	cycloartenol-c-24-methyltransferase	336 aa	311 aa	46.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	sterol 24-c-methyltransferase, putative	0.0232	1	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0159	0.3374	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0159	0.3374	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0159	0.3374	0.5
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0159	0.3374	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0159	0.3374	0.5
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0159	0.3374	0.5
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0159	0.3374	0.5
Onchocerca volvulus		0.0159	0.3374	0.5
Echinococcus granulosus	g protein coupled receptor	0.0159	0.3374	0.5
Schistosoma mansoni	myosin xvIII	0.0159	0.3374	0.5
Brugia malayi	hypothetical protein	0.0159	0.3374	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0159	0.3374	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0159	0.3374	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0159	0.3374	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0159	0.3374	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.0159	0.3374	0.5
Brugia malayi	larval opioid receptor	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0159	0.3374	0.5
Brugia malayi	putative neuropeptide receptor	0.0159	0.3374	0.5
Echinococcus granulosus	neuropeptide receptor	0.0159	0.3374	0.5
Schistosoma mansoni	opsin-like receptor	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Schistosoma mansoni	hypothetical protein	0.0159	0.3374	0.5
Brugia malayi	sulfakinin receptor protein	0.0159	0.3374	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0159	0.3374	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0159	0.3374	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0159	0.3374	0.5
Brugia malayi	Dopamine receptor protein 1	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0159	0.3374	0.5
Schistosoma mansoni	opsin-like receptor	0.0159	0.3374	0.5
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0159	0.3374	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.0159	0.3374	0.5
Echinococcus granulosus	somatostatin receptor	0.0159	0.3374	0.5
Schistosoma mansoni	opsin-like receptor	0.0159	0.3374	0.5
Brugia malayi	hypothetical protein	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0159	0.3374	0.5
Brugia malayi	G protein-coupled receptor	0.0159	0.3374	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0159	0.3374	0.5
Onchocerca volvulus		0.0159	0.3374	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0159	0.3374	0.5
Echinococcus multilocularis	neuropeptide receptor A26	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Brugia malayi	ORL1-like opioid receptor	0.0159	0.3374	0.5
Schistosoma mansoni	hypothetical protein	0.0159	0.3374	0.5
Echinococcus multilocularis	somatostatin receptor	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Brugia malayi	hypothetical protein	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0159	0.3374	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Loa Loa (eye worm)	TYRA-2 protein	0.0159	0.3374	0.5
Schistosoma mansoni	neuropeptide receptor	0.0159	0.3374	0.5
Brugia malayi	hypothetical protein	0.0159	0.3374	0.5
Brugia malayi	neuropeptide F receptor	0.0159	0.3374	0.5
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Echinococcus granulosus	g protein coupled receptor	0.0159	0.3374	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0159	0.3374	0.5
Onchocerca volvulus		0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Onchocerca volvulus		0.0159	0.3374	0.5
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0159	0.3374	0.5
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0159	0.3374	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0159	0.3374	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0159	0.3374	0.5
Echinococcus multilocularis	serotonin receptor	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0159	0.3374	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0159	0.3374	0.5
Onchocerca volvulus		0.0159	0.3374	0.5
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0159	0.3374	0.5
Brugia malayi	Dopamine receptor protein 2	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Echinococcus granulosus	neuropeptide receptor	0.0159	0.3374	0.5
Onchocerca volvulus		0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Brugia malayi	GnHR receptor homolog	0.0159	0.3374	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0159	0.3374	0.5
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0159	0.3374	0.5
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Brugia malayi	hypothetical protein	0.0159	0.3374	0.5
Echinococcus granulosus	7tm_1 domain containing protein	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0159	0.3374	0.5
Schistosoma mansoni	neuropeptide receptor	0.0159	0.3374	0.5
Schistosoma mansoni	amine GPCR	0.0159	0.3374	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0159	0.3374	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0159	0.3374	0.5
Echinococcus granulosus	sex peptide receptor	0.0159	0.3374	0.5
Brugia malayi	hypothetical protein	0.0159	0.3374	0.5
Echinococcus granulosus	neuropeptide receptor A26	0.0159	0.3374	0.5
Trypanosoma cruzi	sterol 24-c-methyltransferase, putative	0.0232	1	0.5
Trypanosoma cruzi	sterol 24-c-methyltransferase, putative	0.0232	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Schistosoma mansoni	hypothetical protein	0.0159	0.3374	0.5
Echinococcus granulosus	dro:myosuppressin receptor	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.0159	0.3374	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0159	0.3374	0.5
Onchocerca volvulus		0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Schistosoma mansoni	amine GPCR	0.0159	0.3374	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0159	0.3374	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0159	0.3374	0.5
Onchocerca volvulus		0.0159	0.3374	0.5
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Trypanosoma cruzi	sterol 24-c-methyltransferase, putative	0.0232	1	0.5
Onchocerca volvulus		0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Brugia malayi	neuropeptide F receptor	0.0159	0.3374	0.5
Schistosoma mansoni	adenoreceptor	0.0159	0.3374	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0159	0.3374	0.5
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0159	0.3374	0.5
Brugia malayi	AKH receptor	0.0159	0.3374	0.5
Onchocerca volvulus		0.0159	0.3374	0.5
Echinococcus granulosus	g-protein coupled receptor	0.0159	0.3374	0.5
Schistosoma mansoni	amine GPCR	0.0159	0.3374	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Brugia malayi	G-protein coupled receptor	0.0159	0.3374	0.5
Echinococcus granulosus	fmrfamide receptor	0.0159	0.3374	0.5
Echinococcus multilocularis	orexin receptor type 2	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Onchocerca volvulus		0.0159	0.3374	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0159	0.3374	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.0159	0.3374	0.5
Schistosoma mansoni	biogenic amine receptor	0.0159	0.3374	0.5
Echinococcus granulosus	allatostatin A receptor	0.0159	0.3374	0.5
Echinococcus granulosus	7TM GPCR rhodopsin	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0159	0.3374	0.5
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0159	0.3374	0.5
Echinococcus granulosus	serotonin receptor	0.0159	0.3374	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0159	0.3374	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0159	0.3374	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0159	0.3374	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0159	0.3374	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0159	0.3374	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0159	0.3374	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0159	0.3374	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0159	0.3374	0.5
Brugia malayi	G-protein coupled receptor	0.0159	0.3374	0.5
Schistosoma mansoni	hypothetical protein	0.0159	0.3374	0.5
Brugia malayi	RE15519p	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0159	0.3374	0.5
Trypanosoma brucei	sterol 24-c-methyltransferase, putative	0.0232	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0159	0.3374	0.5
Onchocerca volvulus		0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Brugia malayi	hypothetical protein	0.0159	0.3374	0.5
Brugia malayi	Serotonin receptor	0.0159	0.3374	0.5
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0159	0.3374	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0159	0.3374	0.5
Schistosoma mansoni	histamine h1 receptor	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Onchocerca volvulus		0.0159	0.3374	0.5
Brugia malayi	Dopamine receptor	0.0159	0.3374	0.5
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0159	0.3374	0.5
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0159	0.3374	0.5
Brugia malayi	Serotonin receptor	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0159	0.3374	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0159	0.3374	0.5
Brugia malayi	hypothetical protein	0.0159	0.3374	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0159	0.3374	0.5
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0159	0.3374	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0159	0.3374	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0159	0.3374	0.5
Onchocerca volvulus		0.0159	0.3374	0.5
Schistosoma mansoni	biogenic amine receptor	0.0159	0.3374	0.5
Echinococcus multilocularis	g-protein coupled receptor	0.0159	0.3374	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0159	0.3374	0.5
Echinococcus multilocularis	serotonin receptor	0.0159	0.3374	0.5
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0159	0.3374	0.5
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0159	0.3374	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0159	0.3374	0.5
Echinococcus granulosus	G protein coupled receptor 139	0.0159	0.3374	0.5
Brugia malayi	hypothetical protein	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Echinococcus granulosus	orexin receptor type 2	0.0159	0.3374	0.5
Echinococcus multilocularis	dro:myosuppressin receptor	0.0159	0.3374	0.5
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0159	0.3374	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0159	0.3374	0.5
Echinococcus granulosus	hypothetical protein	0.0159	0.3374	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0159	0.3374	0.5
Echinococcus multilocularis	G protein coupled receptor 139	0.0159	0.3374	0.5
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0159	0.3374	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0159	0.3374	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0159	0.3374	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0159	0.3374	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0159	0.3374	0.5
Schistosoma mansoni	amine GPCR	0.0159	0.3374	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0159	0.3374	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0159	0.3374	0.5
Schistosoma mansoni	biogenic amine receptor	0.0159	0.3374	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0159	0.3374	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Echinococcus granulosus	g protein coupled receptor	0.0159	0.3374	0.5
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0159	0.3374	0.5
Onchocerca volvulus		0.0159	0.3374	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0159	0.3374	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Trypanosoma brucei	Sterol methyltransferase, putative	0.0232	1	1
Onchocerca volvulus		0.0159	0.3374	0.5
Schistosoma mansoni	amine GPCR	0.0159	0.3374	0.5
Brugia malayi	follicle stimulating hormone receptor	0.0159	0.3374	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0159	0.3374	0.5
Brugia malayi	hypothetical protein	0.0159	0.3374	0.5
Echinococcus granulosus	neuropeptide s receptor	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Trypanosoma brucei	sterol 24-c-methyltransferase, putative	0.0232	1	1
Onchocerca volvulus		0.0159	0.3374	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0159	0.3374	0.5
Schistosoma mansoni	neuropeptide f receptor 76f	0.0159	0.3374	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0159	0.3374	0.5
Brugia malayi	Melatonin receptor type 1A	0.0159	0.3374	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0159	0.3374	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0159	0.3374	0.5
Echinococcus multilocularis	sex peptide receptor	0.0159	0.3374	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Schistosoma mansoni	neuropeptide receptor	0.0159	0.3374	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0159	0.3374	0.5
Schistosoma mansoni	neuropeptide receptor	0.0159	0.3374	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0159	0.3374	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0159	0.3374	0.5
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0159	0.3374	0.5
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3374	0.5
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0159	0.3374	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0159	0.3374	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 6.4 uM	In vitro inhibitory concentration against L. donavani intracellular amastigotes	ChEMBL.	14561091
IC50 (binding)	= 8 uM	In vitro inhibitory concentration against L. major Sterol 24-C-methyltransferase (24-SMT)	ChEMBL.	14561091

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Leishmania donovani	ChEMBL23	14561091

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3138499

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1867528