Detailed view for Tb427.10.6950

Basic information

TDR Targets ID: 19285
Trypanosoma brucei, sterol 24-c-methyltransferase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.1724 | Length (AA): 359 | MW (Da): 40176 | Paralog Number: 1010

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08241   Methyltransferase domain
PF08498   Sterol methyltransferase C-terminal

Gene Ontology

Mouse over links to read term descriptions.
GO:0008168   methyltransferase activity  
GO:0008152   metabolic process  
GO:0006694   steroid biosynthetic process  

Metabolic Pathways

Steroid biosynthesis (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

This protein does not belong to any OrthoMCL cluster.

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) single cell organism (CARO:0000064) bloodstream stage (PLO:0040) inferred from bioassay (ECO:0000094) Trypanosoma brucei brucei No drug identifiers listed for this gene.
Annotator: ts4@sanger.ac.uk. Comment: Drug: azasterol derivatives. . References: 16870747

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.6

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 310 aa 67.2% 308 aa Compounds References
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 161 aa 67.1% 161 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0398 0.3165 0.5109
0.0445 0.512 0.5105
0.0299 0.5129 0.5044
0.0312 0.3293 0.5052
0.00427328 0.277184 0.347875
0.0396 0.5156 0.5112
0.0445 0.512 0.5105
0.0445 0.516 0.516
0.0291 0.4689 0
0.0107 0.4786 0.4776
0.0312 0.3293 0.5052
0.0312 0.3293 0.5052
0.0445 0.516 0.516
0.0101 0.4762 0.4751
0.0446 0.4853 0.4641
0.0389 0.4988 0.4223
0.0455 0.5084 0.5084
0.0312 0.3293 0.5052
0.0293 0.4679 0
0.0328 0.5052 0.5052
0.0445 0.516 0.516
0.0098 0.4819 0.4819
0.02 0.4433 0.4995
0.0102 0.4848 0.4848
0.0308 0.5052 0.5052
0.0446 0.4853 0.4641
0.0332 0.3458 0.5095
0.0306 0.5174 0.5172
0.0308 0.5052 0.5052
0.0103 0.3619 0.355
0.0424 0.3136 0.5094
0.0103 0.3606 0.4499
0.0445 0.516 0.516
0.0106 0.341 0.4763
0.0312 0.3293 0.5052
0.0098 0.4989 0.4989
0.0097 0.4928 0.4802
0.0304 0.5082 0.5051
0.0445 0.516 0.516
0.0424 0.3136 0.5094
0.0334 0.5052 0.5052
0.00427328 0.277184 0.347875
0.0312 0.3293 0.5052
0.0416 0.5145 0.5094
0.0391 0.3048 0.5155
0.0099 0.4854 0.4705
0.0293 0.5129 0.5044
0.0314 0.5133 0.5051
0.0408 0.5167 0.5131
0.0312 0.3293 0.5052
0.0097 0.4786 0.4705
0.0424 0.3136 0.5094
0.0428 0.5087 0.5087
0.0328 0.507 0.507
0.0097 0.4928 0.4802
0.0101 0.3846 0.5002
0.0332 0.3458 0.5095

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

11 literature references were collected for this gene.

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User comments

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Gene identifier Tb427.10.6950 (Trypanosoma brucei), sterol 24-c-methyltransferase, putative
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