Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0215 | 0.1496 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0215 | 0.1496 | 0.5 |
Echinococcus multilocularis | fk506 binding protein | 0.0215 | 0.1496 | 0.1496 |
Trichomonas vaginalis | immunophilin, putative | 0.0215 | 0.1496 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.1661 | 0.122 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0215 | 0.1496 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0215 | 0.1496 | 0.1046 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0483 | 0.3724 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0215 | 0.1496 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0729 | 0.576 | 0.5536 |
Loa Loa (eye worm) | FKBP5 protein | 0.0215 | 0.1496 | 0.1046 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0219 | 0.1534 | 0.5 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0235 | 0.1661 | 0.122 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.1241 | 1 | 1 |
Onchocerca volvulus | 0.0235 | 0.1661 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0235 | 0.1661 | 0.122 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0235 | 0.1661 | 0.122 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.29 | 0.2524 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.1241 | 1 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0384 | 0.29 | 0.6301 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0384 | 0.29 | 0.2524 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0095 | 0.0502 | 0.0502 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0215 | 0.1496 | 0.1046 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.1241 | 1 | 1 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0483 | 0.3724 | 1 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0235 | 0.1661 | 0.122 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0215 | 0.1496 | 0.1046 |
Schistosoma mansoni | immunophilin | 0.019 | 0.1289 | 0.0829 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0215 | 0.1496 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.1661 | 0.122 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0219 | 0.1534 | 0.1087 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0235 | 0.1661 | 0.122 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0215 | 0.1496 | 0.5 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0235 | 0.1661 | 0.122 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0235 | 0.1661 | 0.1661 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0219 | 0.1534 | 0.5 |
Echinococcus multilocularis | caspase 2 | 0.0095 | 0.0502 | 0.0502 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0483 | 0.3724 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.1251 | 0.0788 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0215 | 0.1496 | 0.1046 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0384 | 0.29 | 0.6301 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0235 | 0.1661 | 0.1661 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.019 | 0.1289 | 0.0829 |
Schistosoma mansoni | immunophilin | 0.0219 | 0.1534 | 0.1087 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0215 | 0.1496 | 0.5 |
Onchocerca volvulus | Deterin homolog | 0.0235 | 0.1661 | 1 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.1241 | 1 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.019 | 0.1289 | 0.1289 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0729 | 0.576 | 0.5536 |
Schistosoma mansoni | immunophilin | 0.0219 | 0.1534 | 0.1087 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0215 | 0.1496 | 0.1046 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.1344 | 0.0886 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0235 | 0.1661 | 0.122 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0729 | 0.576 | 0.576 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0215 | 0.1496 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0219 | 0.1534 | 0.1534 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0384 | 0.29 | 1 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0215 | 0.1496 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 37.9 uM | In vitro inhibitory concentration against L. donavani intracellular amastigotes | ChEMBL. | 14561091 |
IC50 (binding) | = 54 uM | In vitro inhibitory concentration against L. major Sterol 24-C-methyltransferase (24-SMT) | ChEMBL. | 14561091 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.