Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alpha-glucosidase | 0.0556 | 0.5148 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0157 | 0 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0556 | 0.5148 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0283 | 0.1624 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0556 | 0.5148 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0556 | 0.5148 | 1 |
Onchocerca volvulus | 0.0274 | 0.1505 | 0.4696 | |
Loa Loa (eye worm) | trehalase | 0.0274 | 0.1505 | 0.1261 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.1505 | 0.1261 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0283 | 0.1624 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0283 | 0.1624 | 1 |
Onchocerca volvulus | Trehalase homolog | 0.0274 | 0.1505 | 0.4696 |
Trichomonas vaginalis | trehalase, putative | 0.0274 | 0.1505 | 0.9054 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0283 | 0.1624 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0556 | 0.5148 | 0.5009 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0196 | 0.0495 | 0.1027 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0283 | 0.1624 | 0.0327 |
Loa Loa (eye worm) | TRE-1 protein | 0.0274 | 0.1505 | 0.1261 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0283 | 0.1624 | 1 |
Onchocerca volvulus | 0.0274 | 0.1505 | 0.4696 | |
Loa Loa (eye worm) | trehalase | 0.0274 | 0.1505 | 0.1261 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0283 | 0.1624 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0196 | 0.0495 | 0.1027 |
Loa Loa (eye worm) | hypothetical protein | 0.0515 | 0.4625 | 0.4471 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0157 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.1505 | 0.1261 |
Loa Loa (eye worm) | trehalase | 0.0274 | 0.1505 | 0.1261 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.1505 | 0.1261 |
Schistosoma mansoni | alpha-glucosidase | 0.0556 | 0.5148 | 1 |
Onchocerca volvulus | 0.0274 | 0.1505 | 0.4696 | |
Loa Loa (eye worm) | TRE-2 protein | 0.0274 | 0.1505 | 0.1261 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.1505 | 0.1261 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0556 | 0.5148 | 1 |
Onchocerca volvulus | 0.0373 | 0.2792 | 1 | |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0283 | 0.1624 | 0.1384 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.1505 | 0.1261 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0274 | 0.1505 | 0.9054 |
Onchocerca volvulus | 0.0274 | 0.1505 | 0.4696 | |
Onchocerca volvulus | 0.0274 | 0.1505 | 0.4696 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 3 uM | Effective dose required for relaxation of the 30 mM KCl-induced contraction of rat aortic rings | ChEMBL. | 12852765 |
IC50 (functional) | = 2.8 uM | Concentration required to inhibit insulin release in rat | ChEMBL. | 12852765 |
ND (functional) | 0 | Inhibition of residual insulin release from rat pancreatic islets in the presence of 16.7mM glucose at 0.1 microM concentration; Not determined | ChEMBL. | 12852765 |
RIS (functional) | = 4.8 % | Percent inhibition of residual insulin release from rat pancreatic islets in the presence of 16.7mM glucose at 50 microM concentration | ChEMBL. | 12852765 |
RIS (functional) | = 23.7 % | Percent inhibition of residual insulin release from rat pancreatic islets in the presence of 16.7mM glucose at 10 microM concentration | ChEMBL. | 12852765 |
RIS (functional) | = 77.2 % | Percent inhibition of residual insulin release from rat pancreatic islets in the presence of 16.7mM glucose at 1 microM concentration | ChEMBL. | 12852765 |
Selectivity (functional) | = 1.1 | Estimated selectivity ratio of ED50 and IC50 in rat was calculated | ChEMBL. | 12852765 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.