Detailed view for LOAG_08234

Basic information

TDR Targets ID: 942832
Loa Loa (eye worm), trehalase
Source Database / ID:  KEGG  

pI: 9.1084 | Length (AA): 599 | MW (Da): 69775 | Paralog Number: 10

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01204   Trehalase

Gene Ontology

Mouse over links to read term descriptions.
GO:0004555   alpha,alpha-trehalase activity  
GO:0003824   catalytic activity  
GO:0005991   trehalose metabolic process  

Metabolic Pathways

Starch and sucrose metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
54 595 2jg0 (A) 37 547 29.00 0 1 1.24804 -0.73
76 573 2jg0 (A) 59 529 34.00 0 1 1.21029 -0.58

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127877)

Species Accession Gene Product
Arabidopsis thaliana AT4G24040   trehalase 1
Brugia malayi Bm1_26450   Trehalase family protein
Brugia malayi Bm1_28500   Trehalase family protein
Brugia malayi Bm1_47400   Trehalase family protein
Brugia malayi Bm1_05750   hypothetical protein
Brugia malayi Bm1_43810   Trehalase family protein
Candida albicans CaO19.7479   neutral trehalase similar to S. cerevisiae NTH1 (YDR001C) involved in stress response
Caenorhabditis elegans CELE_C23H3.7   Protein TRE-5
Caenorhabditis elegans CELE_F57B10.7   Protein TRE-1
Caenorhabditis elegans CELE_W05E10.4   Protein TRE-3, isoform A
Caenorhabditis elegans CELE_T05A12.2   Protein TRE-2
Dictyostelium discoideum DDB_G0283473   hypothetical protein
Drosophila melanogaster Dmel_CG9364   Trehalase
Escherichia coli b3519   cytoplasmic trehalase
Escherichia coli b1197   periplasmic trehalase
Homo sapiens ENSG00000118094   trehalase (brush-border membrane glycoprotein)
Loa Loa (eye worm) LOAG_13910   TRE-2 protein
Loa Loa (eye worm) LOAG_15686   hypothetical protein
Loa Loa (eye worm) LOAG_10778   hypothetical protein
Loa Loa (eye worm) LOAG_12130   hypothetical protein
Loa Loa (eye worm) LOAG_12131   hypothetical protein
Loa Loa (eye worm) LOAG_12754   hypothetical protein
Loa Loa (eye worm) LOAG_12628   hypothetical protein
Loa Loa (eye worm) LOAG_10989   trehalase
Loa Loa (eye worm) LOAG_08992   trehalase
Loa Loa (eye worm) LOAG_03227   TRE-1 protein
Loa Loa (eye worm) LOAG_08234   trehalase
Mus musculus ENSMUSG00000032098   trehalase (brush-border membrane glycoprotein)
Oryza sativa 4349141   Os10g0521000
Onchocerca volvulus OVOC10636  
Onchocerca volvulus OVOC3210  
Onchocerca volvulus OVOC3209  
Onchocerca volvulus OVOC9061   Trehalase homolog
Onchocerca volvulus OVOC7617  
Onchocerca volvulus OVOC7610  
Saccharomyces cerevisiae YDR001C   alpha,alpha-trehalase NTH1
Saccharomyces cerevisiae YBR001C   alpha,alpha-trehalase NTH2
Trichomonas vaginalis TVAG_079440   conserved hypothetical protein
Trichomonas vaginalis TVAG_079430   trehalase, putative

Essentiality

LOAG_08234 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b1197 Escherichia coli non-essential goodall
b3519 Escherichia coli non-essential goodall
CELE_F57B10.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_F57B10.7 Caenorhabditis elegans larval arrest wormbase
CELE_F57B10.7 Caenorhabditis elegans slow growth wormbase
CELE_C23H3.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_C23H3.7 Caenorhabditis elegans larval arrest wormbase
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Bombyx mori Trehalase Compounds References
Homo sapiens trehalase (brush-border membrane glycoprotein) Compounds References
Rattus norvegicus Trehalase Compounds References
Sus scrofa Uncharacterized protein Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0268 0.3299 0.3299
0.0168 0.414 0.3078
0.0318 1 1
0.0302 0.2788 0.2788
0.0318 0.4536 1
0.0318 0.4536 1
0.0159 0.3124 0.9748
0.0318 0.4536 1
0.0302 0.2788 0.2788
0.0318 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier LOAG_08234 (Loa Loa (eye worm)), trehalase
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