Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | androgen receptor | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0024 | 0.6515 | 0.6515 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0.2435 | 0.5 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0024 | 0.6515 | 0.5 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0024 | 0.6515 | 0.6515 |
Schistosoma mansoni | lamin | 0.0033 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0.2435 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0024 | 0.6515 | 0.5 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0024 | 0.6515 | 0.5 |
Chlamydia trachomatis | SWIB complex protein | 0.0024 | 0.6515 | 0.5 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0024 | 0.6515 | 0.6515 |
Echinococcus multilocularis | musashi | 0.0033 | 1 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0024 | 0.6515 | 0.6515 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 1 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0024 | 0.6515 | 0.6515 |
Brugia malayi | brahma associated protein 60 kDa | 0.0024 | 0.6515 | 0.6515 |
Leishmania major | cytochrome p450-like protein | 0.0015 | 0.2435 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0015 | 0.2435 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0015 | 0.2435 | 0.2435 |
Onchocerca volvulus | 0.0024 | 0.6515 | 0.6515 | |
Loa Loa (eye worm) | CYP4Cod1 | 0.0015 | 0.2435 | 0.2435 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.6515 | 0.6515 |
Onchocerca volvulus | 0.0033 | 1 | 1 | |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.3542 | 0.3542 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0024 | 0.6515 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0024 | 0.6515 | 0.6515 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0024 | 0.6515 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.2803 | 0.2803 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 0.2435 | 0.2435 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.9746 | 0.9746 |
Onchocerca volvulus | 0.0033 | 1 | 1 | |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.3542 | 0.3542 |
Plasmodium vivax | hypothetical protein, conserved | 0.0024 | 0.6515 | 0.5 |
Schistosoma mansoni | brg-1 associated factor | 0.0024 | 0.6515 | 0.6515 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0024 | 0.6515 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0033 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0015 | 0.2435 | 0.2435 |
Trypanosoma brucei | cytochrome P450, putative | 0.0015 | 0.2435 | 0.5 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.2803 | 0.2803 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 0.2435 | 0.2435 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.6515 | 0.6515 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2549 | 0.2549 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0024 | 0.6515 | 0.6515 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.2803 | 0.2803 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0024 | 0.6515 | 0.6515 |
Schistosoma mansoni | lamin | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0024 | 0.6515 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0609 | 0.0609 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.6515 | 0.6515 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2549 | 0.2549 |
Loa Loa (eye worm) | brahma associated protein | 0.0024 | 0.6515 | 0.6515 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 1 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0024 | 0.6515 | 0.6515 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (ADMET) | = 58.73727821 % | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | ChEMBL. | 23571415 |
Inhibition (ADMET) | = 64.18539129 % | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | ChEMBL. | 23571415 |
Potency (functional) | 16.9301 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.8493 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.